Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Technical Program Manager
$133K - $235K *
Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...
2 weeks ago
Senior Manager, Global Digital & Technology Systems Engineering
$136K - $181K *
Lead the charge in executing systems engineering activities across R&D, cloud, and AI platforms. Collaborate with stakeholders to ensure seamless integration, compliance, and operational excellence in...
3 weeks ago
Senior Software Engineer, Certificate Management
$186K - $218K *
Transform critical cryptographic infrastructure by leading high-availability services and defining technical strategies. Collaborate across teams to implement secure protocols in a zero-trust environm...
1 week ago
$110K - $145K *
Strategize initiatives to enhance workforce alignment and Agile practices, driving high performance in IT services for federal clients while fostering a collaborative culture and supporting strategic...
2 days ago
Digital Solutions Integration Engineer III
$110K - $130K *
Join a dynamic team to design and support advanced Active Network Management Systems, leading their lifecycle from development to commissioning while ensuring integration with external systems and del...
Today
$117K - $161K *
Elevate your career by designing and optimizing scalable data solutions. Collaborate with cross-functional teams to transform complex data into actionable insights, ensuring high standards of quality...
2 days ago
$110K - $130K *
Transform enterprise IT projects by leading cloud migration and infrastructure modernization initiatives. Drive cross-functional collaboration, manage project lifecycles, and ensure alignment with str...
3 weeks ago
Senior Electrical Engineer (USA)
$120K - $145K *
Empower your career as a Senior Electrical Engineer, leading cutting-edge designs for high-capacity data centers, while collaborating with top industry professionals on impactful, mission-critical pro...
4 weeks ago
Senior Support Engineer - Interoperability
$110K - $148K *
Drive advanced technical support for trading solutions, managing complex incidents, troubleshooting, and collaborating with teams to enhance system performance and ensure exceptional customer experien...
3 weeks ago
Lead Engineer - Thermal-Hydraulic Methods Development
$98K - $188K *
Join a team that's shaping the future of reactor physics and technology. Contribute to computational methods development, numerical analysis, and thermal-hydraulic modeling while supporting software d...
Today
Senior Manager, Engineering & Product Delivery
$80K - $100K *
Lead the execution of software delivery by managing internal teams and vendor partnerships. Oversee backlog management, sprint execution, and ensure alignment between business needs and engineering ca...
1 week ago
Director of Engineering- Integrated Sensor Team
$150K - $180K *
Drive engineering excellence by leading a multidisciplinary team to design, develop, and scale integrated hardware and software systems, ensuring reliability, quality, and operational effectiveness in...
Reposted 4 weeks ago
$108K - $157K *
Optimize data-driven strategies by transforming raw analytics into actionable insights. Collaborate with cross-functional teams to enhance marketplace dynamics and drive measurable business outcomes i...
6 days ago
Staff Developer Platform Engineer
$183K - $200K *
Transform the Developer Platform by enhancing infrastructure and deployment processes. Collaborate with teams to ensure safe, efficient product delivery while driving adoption of innovative tooling an...
1 week ago
Senior Electrical Engineer 2 - Nuclear
$100K - $152K *
Drive innovative electrical designs within nuclear power projects, collaborating with diverse teams to enhance system reliability and performance. Address complex engineering challenges while ensuring...
3 weeks ago
Senior Electrical Engineer 2 - Nuclear
$100K - $152K *
Elevate your career by solving complex electrical engineering challenges in nuclear power. Engage with multi-disciplinary teams to ensure project delivery, from design through installation, while supp...
3 weeks ago
Principal TA Systems Architect
$128K - $205K *
Elevate your career by owning the TA tech stack, driving integrations, and enhancing system efficiency. Collaborate with cross-functional teams to optimize processes and lead vendor relationships, all...
2 weeks ago
Software Development Engineer, Amazon MQ
$168K - $227K *
Join our dynamic team to design and develop open-source message broker systems. Collaborate with peers and project maintainers while leading system architecture and mentoring junior engineers to deliv...
Reposted 4 weeks ago
Staff Backend Engineer - Infrastructure Access - US
$135K - $160K *
Transform the Teleport Core Product by tackling performance, scalability, and security challenges. Lead a distributed team to design, develop, and implement high-quality solutions while enhancing obse...
Yesterday
Manager, Security Design & Delivery
$170K - $200K *
Champion the security design and delivery for hyperscale projects, ensuring comprehensive protection through physical and electronic systems. Collaborate with cross-functional teams to establish stand...
Reposted 2 weeks ago
$145K - $150K *
Lead the charge in developing web-based dissemination tools for external users, collaborating with developers to enhance data visualization and streamline CI/CD processes using modern frameworks and b...
Yesterday
$120K - $145K *
Drive innovation in AI by building and evaluating machine learning models. Collaborate with experts to design experiments, analyze data, and communicate findings effectively to enhance model performan...
1 week ago
$80K - $110K *
Analyze diverse research projects to provide actionable insights for leadership. Collaborate with a dynamic team, utilizing AI tools and your curiosity to tackle complex questions and deliver clear, c...
3 weeks ago
$160K - $190K *
Engage with a dynamic team to represent technical positions in standards communities, author specifications, and build credibility through implementation. This role offers growth opportunities, aiming...
Today
$120K - $165K *
Drive innovative fuel performance analysis to optimize design and support advanced fission solutions. Collaborate across teams, develop methodologies, and document findings to contribute to our clean...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.