Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$100K - $120K *

Empower your career as a Sales Engineer, driving revenue through technical expertise and strategic collaboration. Engage with clients, deliver compelling demos, and streamline the sales process to ach...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Shape the future of security by engineering robust controls for endpoints and email. As a Staff Security Engineer, you'll enhance our security posture, mentor peers, and ensure compliance in a regulat...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $148K *

Manage storage infrastructure for DASD and tape systems, ensuring optimal performance and reliability. Oversee customer migrations, backups, and disaster recovery, while providing expert support and m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Transform engineering processes by developing verification tools, dashboards, and shared infrastructure. Collaborate with teams to enhance quality checks and streamline workflows, ensuring efficient s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$75K - $158K *

Join a dynamic team to ensure the quality and compliance of Oracle HCM systems across federal agencies. Design and execute test strategies, automate testing processes, and validate integrations, ensur...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $189K *

Advance your career by ensuring quality and compliance for a federal HCM platform. Design and execute test strategies, manage automated testing, and validate performance within a SAFe Agile framework...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $165K *

Join a team that's committed to modernizing federal software systems. Lead technical discussions and drive the development of scalable applications using Ruby and Rails in a collaborative environment...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Drive innovation by leading the design and implementation of complex systems, ensuring reliability and scalability while aligning engineering solutions with business objectives in federal IT moderniza...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$160K - $250K *

Transform customer experiences by leading technical sales solutions for wireless routers and managed services. Collaborate with partners and clients across diverse industries, ensuring optimal connect...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$161K - $242K *

Lead the charge in driving the cardiology portfolio's growth and modernization. Own strategy, adoption, cloud migration, and pricing while collaborating across teams to enhance patient outcomes and op...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$148K - $261K *

Transform the infrastructure landscape by architecting and scaling a Kubernetes-based platform that enables rapid deployment of innovative robotics solutions while mentoring engineers across teams to...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Lead the charge in architectural innovation and strategic direction, shaping long-term technical landscapes and enabling cross-functional execution at scale while mentoring senior technical leaders an...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$100K - $120K *

Empower user experiences by leading comprehensive design solutions through UX/UI integration. Collaborate with founders and teams to innovate effective strategies and enhance customer satisfaction in...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Empower strategic data initiatives by leading design, development, and analytics projects. Drive data migration, modernize data solutions, and ensure quality standards while collaborating with stakeho...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Drive execution of complex technical initiatives, translating business vision into actionable programs. Collaborate with cross-functional teams to ensure alignment with company objectives and measurab...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$177K - $236K *

Transform the future of technology as a Principal Software Engineer, leading AI experimentation and prototyping. Collaborate across teams to design scalable solutions, mentor engineers, and drive inno...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$75K - $95K *

Join a dynamic team as you support sales operations by delivering precise price quotations and coordinating solutions. Collaborate across functions to drive business success and enhance customer relat...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$186K - $218K *

Shape the future of AI-driven trading by developing backend services that enhance user experience and ensure reliable execution for millions of customers. Collaborate across teams to deliver innovativ...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$145K - $175K *

Innovate and lead a data engineering team to drive AI strategies, optimizing IT architecture while ensuring data integrity and compliance, enhancing performance across various projects in an agile env...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$156K - $180K *

Empower clients by owning technical relationships for the Enterprise Suite, guiding them from discovery to implementation. Collaborate with teams to enhance adoption and resolve issues, ensuring seaml...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$145K - $155K *

Support the implementation and enhancement of a modern data platform, collaborating with technical teams and stakeholders to build scalable data pipelines and improve data quality for MI and BI initia...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the design and optimization of mechanical systems for data centers, ensuring reliability, energy efficiency, and compliance. Collaborate with cross-functional teams to enhance operational perform...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$165K - $248K *

Lead enterprise-scale operations for cloud services, ensuring performance and customer satisfaction. Drive a multidisciplinary team, manage service transitions, and leverage data-driven metrics to enh...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$198K - $292K *

Help us shape the future of autonomous systems by designing and deploying advanced motion planning algorithms for dynamic environments, ensuring safe and efficient navigation in real-time scenarios wh...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$133K - $235K *

Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.