Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior ML Systems Engineer, Inference
$150K - $220K *
Transform LLM inference efficiency by leading the performance measurement, diagnosis, and enhancement efforts to optimize customer experience through cost-effective and speedy solutions in a hands-on...
3 weeks ago
Principal Product Manager, Scaled Content Systems
$500K+*
Lead the transformation of media ingestion and distribution systems, driving automated, AI-powered workflows that enhance efficiency and accelerate content delivery to a global audience. Collaborate a...
3 weeks ago
Senior Software Engineer, AWS Cloud Infrastructure
$12K - $150K *
Lead the charge in building and securing AWS infrastructures, driving operational excellence across scalable architectures. Enhance systems reliability and governance while mentoring teams and fosteri...
4 weeks ago
Senior Director, Workforce Transformation
$225K - $270K *
Lead the charge in Workforce Transformation by measuring AI’s impact, redesigning roles, and shaping skills for the future. Collaborate with cross-functional leaders to anticipate workforce needs and...
4 weeks ago
Technical Program Manager, Network
$180K - $230K *
Lead complex, multi-workstream technology programs, ensuring alignment across teams and delivering customer outcomes through strategic planning, execution, and governance. Drive program success by man...
3 days ago
$109K - $145K *
Contribute to the development of a cloud storage solution, designing and delivering features for a medical imaging platform. Collaborate within an Agile team, taking ownership of the development lifec...
2 days ago
$120K - $140K *
Lead the charge in developing strategic reference data platforms, ensuring high-quality delivery across all SDLC phases. Collaborate with global teams to enhance system architecture and provide top-ti...
1 week ago
Agentic Solution Architect / Tech Lead
$135K - $160K *
Pioneer the integration of AI solutions within product development, leading the charge on an AI-native framework. Collaborate across teams to transform SDLC practices, delivering cutting-edge automati...
3 weeks ago
$125K - $150K *
Shape the future of our product experiences by building high-impact frontend features. Collaborate with cross-functional teams to deliver maintainable, efficient code using modern frameworks in a dyna...
Reposted 3 weeks ago
Staff Software Engineer: Database Reliability Engineering
$120K - $145K *
Champion the modernization of enterprise data tiers by automating database reliability engineering across hybrid cloud environments, enhancing performance, and ensuring high availability for mission-c...
Today
$113K - $142K *
Engineer innovative electrical designs for modular data centers, ensuring compliance and performance across international standards. Collaborate with teams to deliver hands-on solutions from concept t...
Yesterday
$175K - $185K *
Engage with Federal agencies and software providers to design and implement secure cloud solutions. Leverage your expertise in FedRAMP and DoD IL4 to drive technical sales strategies and ensure compli...
2 weeks ago
$120K - $145K *
Lead the design and implementation of robust security measures to protect sensitive health information, ensuring compliance with HIPAA and other regulations while collaborating with cross-functional t...
3 weeks ago
$90K - $105K *
Join a team that's dedicated to enhancing system reliability and performance for critical defense projects. Leverage your engineering expertise to implement best practices and drive data-driven improv...
2 weeks ago
Principal Site Reliability Engineer, Platform Engineering: Dedicated
$223K - $380K *
Drive the evolution of a single-tenant SaaS platform, enhancing reliability, security, and operational efficiency while leading technical transformations, mentoring engineers, and influencing cross-te...
4 weeks ago
Technical Lead Manager, Developer Platform
$180K - $220K *
Empower developers as you lead a small team building tools, APIs, and integrations for a platform that enhances creator engagement. Balance hands-on engineering and management while driving technical...
1 month ago
Product Manager - Foundation Engineering
$158K - $248K *
Champion the development of the product roadmap for Observability and Compute/Network teams, ensuring alignment with reliability goals, system health monitoring, and infrastructure management strategi...
3 weeks ago
Staff Software Engineer - 340B Check
$170K - $200K *
Lead technical direction for a healthcare data team, driving architectural decisions and cross-team initiatives to enhance compliance and operational efficiency. Elevate team performance while solving...
Yesterday
Test Automation Engineer (Remote)
$115K - $120K *
Champion quality assurance by developing and maintaining automated test solutions. Collaborate with cross-functional teams to integrate testing into CI/CD pipelines, ensuring comprehensive coverage an...
2 weeks ago
$220K - $250K *
Engage with enterprise clients as a Solutions Engineer, driving technical sales and evaluations. Collaborate with Account Executives to design solutions, validate deployments, and ensure customer succ...
2 weeks ago
$115K - $150K *
Architect and streamline cloud network infrastructure. Support robust security and connectivity across Azure, OpenShift, and SASE platforms. Collaborate with cross-functional teams, ensuring optimal p...
4 weeks ago
$73K - $109K *
Drive your career with impactful service as you troubleshoot and maintain advanced medical equipment, ensuring optimal performance and customer satisfaction across the Pacific Region, with a focus on...
1 week ago
$72K - $108K *
Join a team that's dedicated to delivering exceptional service through timely maintenance and support for medical equipment. Collaborate with experienced engineers to enhance your skills while ensurin...
1 week ago
$73K - $109K *
Champion customer satisfaction by mastering preventative maintenance and troubleshooting techniques. Collaborate with experienced engineers to enhance skills in equipment installation and service, ens...
2 weeks ago
$66K - $99K *
Play a key role in delivering exceptional service by performing preventative maintenance and troubleshooting on medical equipment. Collaborate with experienced engineers to enhance customer satisfacti...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.