Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$125K - $135K *

Join a team that's dedicated to overseeing personnel and operational execution across critical Navy training programs. Lead multidisciplinary teams, manage contracts, and ensure successful program del...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Technical Services

$85K - $125K *

Unlock your potential as an AI-first Software Engineer, driving innovation in mobile marketplace experiences. Collaborate with cross-functional teams to enhance product quality and efficiency while le...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$106K - $284K *

Elevate your career by leading the design and development of innovative healthcare platforms. Collaborate with cross-functional teams to deliver scalable, secure applications that enhance user experie...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$73K - $102K *

Join a team that's shaping the future of AI by architecting and deploying LLM-powered applications. Leverage your expertise in Python and modern frameworks to deliver scalable, intelligent solutions t...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$173K - $233K *

Lead the charge in developing high-availability backend systems, collaborating with cross-functional teams to deliver impactful solutions while fostering a culture of quality and ownership within your...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $90K *

Transform the IT landscape by enhancing cloud services and user systems. Play a key role in optimizing platforms like Azure, O365, and Jira, while driving efficiencies through automation and collabora...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$72K - $111K *

Elevate quality assurance efforts for ITSM applications by devising test strategies, executing various testing methodologies, and ensuring stakeholder acceptance. Drive continuous improvement while co...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$260K - $310K *

Transform the engineering landscape by leading dual teams in the Clinical Division, driving technical excellence and career growth, while effectively managing product delivery and leveraging AI capabi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$145K - $165K *

Design and deliver AI solutions within clinical and product teams, spearheading validated features while ensuring compliance. Collaborate across functions to enhance AI fluency and operational capabil...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$152K - $190K *

Join a dynamic team to help developers secure applications by integrating innovative solutions into their processes. Enhance customer engagement through technical guidance to ensure efficient vulnerab...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive mobile engineering excellence across diverse product teams, ensuring strategic direction, fostering collaboration, and enhancing delivery. Lead managers, shape architecture, and cultivate a prod...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$60K - $152K *

Engage with clients to deliver exceptional software support for MQ on mainframe systems. Collaborate across teams to ensure timely installations, upgrades, and migrations while adhering to best practi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Join a dynamic team to shape the future of AI computing. Leverage your expertise in neural networks and machine learning to design innovative solutions and enhance performance across advanced systems...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $175K *

Elevate your career by leading innovative solar and energy storage projects. Drive technical excellence, mentor teams, and collaborate with stakeholders to shape sustainable energy solutions across No...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$130K - $155K *

Lead data architecture initiatives by optimizing serverless data pipelines and enhancing analytics capabilities through AWS services like SageMaker and Glue. Collaborate on data lakes and AI integrati...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $180K *

Drive the modernization of Veterans Benefits Administration claims processing by designing and optimizing scalable data pipelines and solutions, ensuring efficient data integration and analytics for i...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$137K - $183K *

Champion web accessibility by enhancing the Gecko accessibility engine, collaborating with teams, and solving complex coding challenges. Utilize your C++ expertise to create a more inclusive web exper...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $209K *

Accelerate progress at the intersection of machine learning and software engineering, driving innovative solutions for ticketing optimization, personalization, and fraud detection. Collaborate across...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$135K - $160K *

Champion the delivery of innovative data solutions, leading cross-functional teams to modernize platforms and drive AI integration. Ensure project success through effective management of scope, qualit...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$116K - $125K *

Elevate cybersecurity measures by designing and implementing robust controls for enterprise applications and infrastructure. Collaborate with cross-functional teams to ensure compliance with federal s...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$128K - $165K *

Lead reliability initiatives across complex systems, driving automation and observability. Collaborate with teams to enhance operational outcomes, manage incidents, and mentor engineers, ensuring comp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $212K *

Pioneer innovative IAM strategies to enhance security across cloud and on-premise infrastructures. Collaborate with cross-functional teams to implement robust identity governance and access management...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $160K *

Join our U.S. Government Support Engineering team to tackle complex technical challenges in secure environments. Leverage your Linux expertise and customer support skills to enhance GitLab's performan...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $150K *

Advance your career by leading product strategy for supply chain orchestration. Drive technical decisions, collaborate with cross-functional teams, and leverage AI to enhance workflows, ensuring measu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$102K - $170K *

Lead the charge in full-stack development, collaborating on enterprise modernization with Microservices. Deliver high-quality software, mentor engineers, and ensure best practices for cloud technologi...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.