Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$150K - $180K *

Accelerate progress at a dynamic engineering team, tackling complex technical challenges while delivering high-quality code. Own architectural decisions and enhance integration across services in a co...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Enterprise Technology

$130K - $155K *

Unlock potential by leading the design and development of enterprise applications using C# and .NET, driving modern software practices, and collaborating with cross-functional teams to implement secur...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Drive the design and development of innovative software solutions while mentoring junior engineers. Leverage extensive technical expertise to enhance system architecture and ensure high-quality delive...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$132K - $176K *

Transform your career by leading the design and implementation of innovative DevOps practices that accelerate software delivery and operational excellence in a high-accountability environment. Drive c...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Empower cross-functional teams to consolidate payment gateways, leveraging deep USA Payments expertise. Collaborate with stakeholders to analyze requirements, drive migrations, and ensure seamless int...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $158K *

Drive robust application security integration within the SDLC while collaborating with development teams to analyze and mitigate vulnerabilities. Engage in proactive testing and ensure compliance, enh...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $210K *

Empower Federal agencies by architecting and delivering AI-assisted software solutions. Responsible for client engagement, technology integration, and ensuring that production-ready solutions meet ope...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$130K - $155K *

Join a team that designs and deploys lab environments for Cloud Security Posture Management using advanced OpenStack expertise. Contribute to testing and validating API-based security tools in multi-t...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $190K *

Empower your career by developing innovative solutions for a cloud-native platform, enhancing endpoint management for global clients. Collaborate with a dynamic team to drive impactful features and en...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$193K - $309K *

Innovate AI-driven automations for customer care, enhancing workflows and agent efficiency. Collaborate across teams to transform service operations, leveraging intelligent systems for improved custom...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the charge in enhancing security for a complex federal platform, safeguarding cloud infrastructure and sensitive data. Collaborate within an Agile team to design, implement, and automate robust s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $114K *

Transform data systems and pipelines to empower AI/ML applications, collaborating with technical teams to enhance mission-critical operations and ensure data quality across the Navy IT ecosystem...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Champion the successful delivery of customer projects through all phases, ensuring alignment with business goals by coordinating teams and resources while managing risks and transacting key communicat...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $140K *

Lead the charge in designing and executing rail projects, ensuring compliance and quality. Collaborate with multidisciplinary teams and strengthen client relationships while managing project delivery...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$67K - $92K *

Join a team that's dedicated to ensuring software quality through automated testing. Collaborate with developers, execute test cases, and leverage AI tools to enhance testing processes while participa...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $362K *

Drive innovation and develop cutting-edge technology solutions that impact a global market. Collaborate with teams to shape product strategies, mentor experts, and influence industry standards while e...

RemoteRemote

Reposted 1 month ago

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$132K - $165K *

Lead the charge in building cutting-edge data lakes and warehouses, guiding cross-functional teams to optimize data strategies, ensuring robust architecture, and mentoring junior engineers in a dynami...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Join a dynamic team to design and implement AI workflows that integrate models, enterprise data, and business logic, delivering reliable production solutions and collaborating with various stakeholder...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$153K - $214K *

Drive the evolution of our SaaS platform as a Senior Developer focused on enhancing IT insights and governance, collaborating in a dynamic team to build scalable solutions that tackle modern challenge...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Lead the development of innovative Provider Onboarding solutions, architecting robust systems and mentoring engineers to enhance mental healthcare access. Drive product implementations and build scala...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Lead and develop dynamic engineering teams to enhance communication systems that improve health equity outcomes for underserved patients. Drive technical direction, manage shared codebases, and collab...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Empower the development of mission-critical applications on the ServiceNow platform, collaborating with stakeholders to deliver scalable solutions while ensuring compliance with federal standards and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in modernizing SaaS solutions by integrating AI and automation to enhance delivery efficiency, scalability, and customer outcomes while supporting complex migration projects and foster...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Reimagine data governance by shaping a robust framework that empowers teams to define, manage, and optimize data products with clear accountability, streamlined workflows, and effective collaboration...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Join a team that's shaping the future of data technology, transforming businesses through strategic data solutions. Drive impactful projects, collaborate with industry leaders, and unlock data potenti...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.