Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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$110K - $130K *

Accelerate progress at the forefront of dental technology by leading software development for specialized machines, shaping the future of custom prosthetics manufacturing in a dynamic, high-growth env...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$190K - $267K *

Join a team that's redefining web performance and developer experience. You'll tackle complex platform challenges, optimize Shreddit’s architecture, and enhance tooling for a high-traffic site, empowe...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$110K - $130K *

Optimize end-to-end project delivery by developing customer-facing products and internal tools. Collaborate with stakeholders to rapidly turn needs into functional solutions, leveraging AI and modern...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $130K *

Empower your career by leading quality assurance efforts for critical healthcare systems. Collaborate with teams to enhance user experiences for Veterans, ensuring high-quality service delivery throug...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $150K *

Empower the development of key backend services and APIs, enhancing KeeperApp functionality. Leverage your expertise in Java and SQL to optimize performance while collaborating on innovative cybersecu...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $185K *

Lead cross-functional teams to drive excellence in software development for a SaaS platform, ensuring timely delivery and high-quality outcomes while fostering a collaborative engineering culture. Inn...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$105K - $231K *

Accelerate progress at the forefront of SAP integration, driving complex data exchanges and ensuring compliance with DoD standards while enhancing transportation operations across diverse systems...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$150K - $175K *

Shape the cloud infrastructure landscape by ensuring security, scalability, and efficiency. Collaborate with engineers to build resilient systems and drive best practices, enabling smooth deployment a...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $232K *

Drive innovation and excellence in electrical engineering projects, ensuring compliance and efficiency. Collaborate with cross-functional teams to optimize data center infrastructure and mentor junior...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$156K - $262K *

Join a dynamic team to design and optimize scalable data pipelines and infrastructure, enabling analytics and AI-driven capabilities. Collaborate across functions to deliver high-quality data solution...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$200K - $350K *

Transform complex AI research into scalable, reliable systems. Collaborate across teams to architect and enhance backend services, ensuring robust infrastructure for model training and data collection...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$186K - $218K *

Elevate operational excellence by engineering reliable Kubernetes solutions that streamline compute orchestration, enhance automation, and drive AI integration for a robust developer experience across...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Lead the design and management of robust and scalable network infrastructure for hyperscale data centers. Collaborate with cross-functional teams to ensure high performance and reliability in support...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$89K - $148K *

Unlock potential by leveraging your electrical engineering expertise to support military vessel operations. Collaborate with teams to ensure safe, reliable electrical systems while managing design and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Pioneer the future of AI as a Senior Engineer specializing in semantic web technologies, bridging business and tech to create scalable data solutions that enhance analytics, knowledge management, and...

RemoteRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $165K *

Lead the charge in designing and deploying cutting-edge LLM applications that solve real user challenges. Drive the full AI development lifecycle, ensuring quality and scalability while transforming i...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Innovate cutting-edge AI financial solutions by architecting and deploying advanced chat interfaces and reporting systems. Collaborate with elite engineers to enhance investment workflows for global c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Shape the future of AI solutions by leading design and implementation of robust enterprise systems, driving innovation, and establishing engineering excellence while mentoring developers and collabora...

RemoteRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$106K - $284K *

Drive innovative software development strategies while leading cross-functional teams to deliver high-quality solutions. Foster collaboration, mentor talent, and manage project timelines to achieve or...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the configuration and support of Infor M3 non-finance modules, driving business process analysis and continuous improvement. Collaborate with teams to ensure effective implementation and user tra...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$128K - $184K *

Innovate as a Software Engineer, building backend services for secure access in complex environments. Collaborate with experts to enhance performance and reliability while expanding your skills in dis...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$200K - $250K *

Champion innovative and scalable Trading & Custody systems by leading cross-functional projects and collaborating closely with product and compliance teams, while inspiring the engineering team with a...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Pioneer innovative solutions by partnering with customers and teams to transform AI and HPC requirements into reliable deployments, driving success through technical depth and collaboration across fun...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $150K *

Lead the charge in designing and implementing HR Service Delivery solutions, integrating Microsoft 365 with ServiceNow. Optimize employee experiences through automated workflows and seamless connectio...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.