Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$110K - $130K *

Empower clinical research by leading studies in infectious diseases, ensuring scientific integrity and collaboration with stakeholders. Drive trial design, monitor data, and support medical activities...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform clinical trial expertise into impactful project delivery. Oversee research integrity, lead cross-functional teams, and promote operational excellence to ensure successful trial execution wit...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$222K - $267K *

Transform healthcare through effective utilization management and collaborative leadership. Play a key role in developing policies ensuring high-quality patient care and cost containment within a dyna...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$206K - $242K *

Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$143K - $179K *

Shape and lead client implementations for a cutting-edge trading platform, guiding asset and wealth managers through system configuration and go-live processes while ensuring client satisfaction and p...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $220K *

Shape global medical strategies for MMN, driving evidence generation and launch readiness. Collaborate with cross-functional teams to translate insights into impactful actions, enhancing patient outco...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$246K - $332K *

Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...

RemoteRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $130K *

Lead the charge in delivering exceptional healthcare for seniors by combining your nursing expertise with strong administrative skills to enhance nursing operations and team performance...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$262K - $404K *

Optimize patient care and operational leadership as you manage Anesthesia APP teams, ensure regulatory compliance, and build strong client relationships while driving growth in practices and enhancing...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Join a team that's focused on empowering ABA practice owners by enhancing operational performance, driving growth, and delivering tailored strategic solutions to complex challenges, ensuring high-qual...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$79K - $118K *

Join a team that's dedicated to providing exceptional patient care in a fast-paced orthopedic unit. As a compassionate RN, you'll coordinate comprehensive care, ensuring safety and quality outcomes fo...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$127K *

Contribute to transforming virtual primary care by delivering exceptional patient assessments, treatment plans, and ongoing support. Collaborate with healthcare teams while leveraging technology to en...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Join a team that's dedicated to providing comprehensive mental health care across various settings. Lead clinical and administrative efforts, supervise staff, and ensure quality treatment for patients...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $220K *

Transform mental health services by providing clinical and administrative leadership, supervising staff, and ensuring quality care across various psychiatric settings. Engage in training, oversight, a...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$173K - $310K *

Transform clinical AI solutions by leveraging your expertise in patient care and research. Collaborate cross-functionally to enhance clinical accuracy and support strategic partnerships, ensuring the...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $160K *

Join a dynamic team of engineers to develop innovative software solutions, enhance user experiences, and drive impactful projects. Collaborate across functions while embracing modern technologies and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $190K *

Help us shape the future of AI operations by leading a dynamic team focused on innovative solutions, strategic partnerships, and technical excellence in agentic environments. Drive growth and operatio...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Champion efficient health center operations while delivering quality patient care. Oversee staff management, process improvements, and compliance initiatives to enhance health outcomes and ensure a se...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join us to design and implement innovative process automation solutions utilizing UiPath and QuickBase technologies, addressing complex challenges across various business areas while adhering to estab...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $250K *

Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $230K *

Lead a team that operationalizes advanced AI security solutions for enterprises, ensuring integration and compliance across environments. Collaborate with stakeholders to translate requirements into e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $190K *

Elevate healthcare solutions by transforming complex data needs into scalable systems. Collaborate with cross-functional teams to design and build data pipelines and insightful dashboards that enhance...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$160K - $200K *

Lead innovative strategies to optimize Patient Access programs, partnering across teams to enhance service delivery, drive customer value, and elevate market presence, ensuring the best outcomes for p...

North Carolina, USRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion faculty success by developing and delivering innovative professional learning programs. Collaborate with stakeholders to enhance instructional quality and faculty engagement while ensuring al...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Join a team that's dedicated to evaluating subsurface data and collaborating on environmental projects. You'll oversee field investigations, prepare reports, and ensure quality standards while mentori...

5 days ago

  •   5 - 7 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.