Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$145K - $165K *

Design and deliver AI solutions within clinical and product teams, spearheading validated features while ensuring compliance. Collaborate across functions to enhance AI fluency and operational capabil...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Champion comprehensive mental health care by evaluating, diagnosing, and treating diverse adult and child populations. Leverage technology and EHR systems to enhance patient outcomes and ensure effect...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Provide patient-focused care in a dynamic urgent care environment, delivering services such as telemedicine, minor surgeries, and general evaluations. Collaborate with diverse teams to ensure high-qua...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Lead the charge in providing comprehensive patient care in a dynamic urgent care setting. Empower a small team while utilizing your full scope of practice to treat diverse patient populations and enha...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Unlock potential by providing comprehensive patient care in a fast-paced urgent care setting. Lead a dedicated team while utilizing your full scope of practice to serve diverse patient needs and suppo...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Join a team that's dedicated to providing comprehensive patient care in a fast-paced urgent care environment. Lead a small team while utilizing your full scope of practice to treat diverse patient nee...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Join a dynamic team providing comprehensive urgent care services. Lead patient-focused care, utilizing your full scope of practice in a fast-paced environment. Support rural communities while enhancin...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Join a dynamic team as a Family Nurse Practitioner, providing comprehensive care in a fast-paced urgent care setting. Lead a small team, utilize your full scope of practice, and make a meaningful impa...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Elevate your career by providing comprehensive patient care in a dynamic urgent care setting. Lead a dedicated team while utilizing your full scope of practice to serve diverse communities and enhance...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Join a team that's dedicated to providing comprehensive patient care in a fast-paced urgent care environment. Lead a small team while utilizing your full scope of practice to treat diverse patient nee...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Empower your career with a dynamic role providing comprehensive patient care in a fast-paced urgent care setting. Lead a supportive team while utilizing your full scope of practice to make a meaningfu...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Serve diverse patient populations by leading a dynamic team in a fast-paced, urgent care setting. Empower growth in your career while providing essential care across all age groups, ensuring community...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$280K - $481K *

Join a team that's driving growth in advanced therapeutics through strategic leadership, P&L accountability, and innovative business development. Shape the future of RNA oligonucleotide manufacturing...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$200K - $250K *

Join us in shaping technical strategies and growth initiatives for federal opportunities. Collaborate across teams to develop compelling solutions that drive success in complex pursuits, ensuring alig...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock potential by shaping innovative solutions for Opioid Treatment Programs and Medication Assisted Treatment. Collaborate with clients and teams to translate complex needs into actionable product...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$119K - $179K *

Optimize clinical data integration by architecting FHIR-compliant models, harmonizing disparate data streams, and ensuring data accuracy to enhance patient care and research initiatives across the org...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$261K - $346K *

Lead the charge in clinical pharmacology strategies for rare disease and oncology programs, driving innovative solutions, study designs, and regulatory interactions to expedite drug development and im...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Shape patient care by joining a thriving urology practice as an advanced practice provider. Operate autonomously in a supportive environment, seeing patients and performing essential office procedures...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$120K - $170K *

Shape the future of enterprise infrastructure by leading design, implementation, and optimization of systems. Drive automation, enhance security, and mentor junior staff while collaborating on strateg...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$119K - $179K *

Lead the charge in architecting FHIR-compliant data models to enhance clinical data integration and usability, supporting patient care and research initiatives across the organization...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $230K *

Elevate your career by joining a collaborative team focused on delivering exceptional outpatient primary care. Enjoy competitive compensation, a supportive environment, and a balanced lifestyle in a s...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Shape the future of cybersecurity in higher education by delivering expert assessments, advisory services, and tailored remediation plans that empower institutions to enhance their security posture an...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $90K *

Unlock potential by providing compassionate, individualized ABA care to children with autism. Collaborate with caregivers and maintain clinical integrity while fostering a supportive environment for p...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Elevate patient care by evaluating and treating diverse dermatologic conditions. Collaborate with a skilled team to deliver exceptional service in a thriving practice focused on general, cosmetic, and...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Pioneer patient-centered care by joining a growing dermatology team. Leverage your experience to enhance workflows, build patient relationships, and contribute to a thriving practice focused on commun...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.