Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$115K *

Help us streamline our People Operations by managing payroll, compliance, and employee relations. Collaborate cross-functionally to build scalable systems and support our growing team across multiple...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Discover the opportunity to lead and optimize Advanced Practice Providers in a dynamic behavioral health setting. Collaborate across interprofessional teams to improve service delivery, enhance access...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$200K - $250K *

Transform provider engagement by leading peer-to-peer conversations and ensuring clinical governance. Leverage your medical expertise to enhance patient safety and optimize drug strategies while repre...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $110K *

Empower clinical teams to deliver high-quality, evidence-based ABA therapy. Lead and mentor professionals while collaborating across functions to enhance client care and support growth in a compassion...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate patient care by joining our interdisciplinary team as an Advanced Practice Provider. Collaborate with physicians to deliver high-quality, evidence-based healthcare while engaging in education...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Join our interdisciplinary healthcare team to provide high-quality, cost-effective patient care as an Advanced Practice Provider. Collaborate with physicians, lead initiatives, and enhance patient out...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$87K - $131K *

Engineer and support end-user systems, ensuring optimal performance and alignment with IT architecture. Collaborate with teams to design solutions, manage technologies, and provide Tier III support, e...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$375K - $400K *

Partner with us to provide exceptional patient-centered care in a vibrant concierge practice offering 24/7 access and a focus on wellness, prevention, and comprehensive coordination tailored to indivi...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$200K *

Drive your career by leading technical architecture and AI tooling development in a dynamic company transitioning to multi-platform solutions. Collaborate with teams, mentor talent, and engage with en...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$300K - $350K *

Take ownership of trauma care as a Trauma Medical Director, leading a Level 1 ACS program, mentoring residents and collaborating within a stable, supportive team focused on surgical excellence and cri...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Drive growth as an integral part of our Commercial Sales Team, managing key health system relationships and closing complex deals, while collaborating across departments and shaping the product roadma...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$210K - $240K *

Lead strategic relationships with influential optometrists and ophthalmologists, shaping the Presbyopia ecosystem through education and engagement. Drive insights and collaboration across medical, mar...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Optimize patient care as a Nursing Practitioner or Physician Assistant, overseeing clinical operations while enhancing patient experiences. Collaborate with healthcare teams and participate in ongoing...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Staffing

$210K - $250K *

Join us to lead and enhance Rheumatology services across multiple sites, ensuring high-quality patient care, fostering education, and driving operational excellence in a complex healthcare environment...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Unlock potential by delivering high-quality, patient-centered care as part of an interdisciplinary team. Collaborate with physicians to implement treatment plans, educate patients, and lead initiative...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$117K - $160K *

Join our dynamic General Surgery Team as an Advanced Practice Provider, where you'll assist in the operating room, conduct inpatient rounds, and engage in clinic activities, all while collaborating wi...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$206K - $268K *

Lead the charge in advancing nephrology clinical programs through strategic design, execution, and analysis of clinical trials, ensuring compliance with Good Clinical Practices while collaborating wit...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$297K - $367K *

Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$170K - $205K *

Join a dynamic team to lead AI agent deployments in healthcare. Leverage your software engineering expertise and client-facing skills to drive technical delivery, influence product development, and en...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $115K *

Champion clinical excellence by leading and mentoring a dynamic ECM team, ensuring comprehensive patient care and adherence to individualized plans, while collaborating effectively with multidisciplin...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Join a dedicated team in providing quality medical care within a correctional facility. As a Staff Physician, you'll diagnose, treat, and manage patient health while ensuring compliance with regulatio...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $110K *

Lead clinical teams to deliver high-quality ABA therapy, mentor staff, and drive client progress in a supportive, mission-driven environment focused on excellence and growth...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Empower clients' mental health journeys through tele-psychiatric care, conducting evaluations, developing treatment plans, and working within a flexible schedule to achieve positive outcomes in a supp...

North Carolina, USRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$208K - $250K *

Lead the charge in advancing a dynamic urology program, providing clinical care, overseeing resident training, and engaging in research. Collaborate with a dedicated team to enhance patient outcomes a...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$350K - $430K *

Join a team that's at the forefront of ophthalmic genetic medicine development. Provide strategic oversight for clinical studies, ensuring patient safety and data integrity while collaborating with cr...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.