Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Field Application Engineer - Data Center Solutions
$96K - $205K *
Empower the Data Center Solutions team by providing expert technical support, evaluating customer needs, and leading strategic projects across the Central US and Latin America, ensuring optimal produc...
1 week ago
Staff Engineer Cloud Scalability
$174K - $220K *
Pioneer significant enhancements in cloud infrastructure, optimizing capacity and performance. Drive cross-functional collaboration to ensure scalability and reliability while shaping best practices...
Reposted today
$104K - $156K *
Unlock your potential as a Solutions Engineer, driving sales success by leveraging technical expertise to address customer challenges and deliver F5 solutions. Collaborate with sales teams to achieve...
2 weeks ago
$95K - $115K *
Transform traffic management by optimizing signal systems for efficient movement of people and goods. Collaborate with cross-functional teams to enhance product deployment and support, ensuring safety...
1 week ago
$135K - $160K *
Unlock potential by shaping mobile development solutions and guiding implementation teams to deliver projects following your architectural designs, ensuring quality and effectiveness throughout the de...
Reposted today
$120K - $145K *
Join a team that's enhancing data integration for the U.S. Coast Guard. As a Senior Systems Engineer, you'll lead the implementation and maintenance of the Cloud Data Pipeline, ensuring robust data sh...
4 days ago
$163K - $245K *
Shape security architecture by designing robust frameworks across various tech domains. Collaborate with cross-functional teams to ensure comprehensive cybersecurity solutions aligned with business go...
Reposted 3 weeks ago
$110K - $130K *
Champion AI deployment by designing and implementing innovative solutions across multiple platforms. Collaborate with teams to enhance customer experiences while ensuring data governance and security...
3 weeks ago
Cloud Security Architect - St. Louis, MO
$120K - $145K *
Engage as a key security authority within the engineering team, guiding security best practices across Azure and Kubernetes. Own compliance posture and support engineers in making informed security de...
1 week ago
$83K - $125K *
Drive the operational health of mission-critical Appian environments, ensuring reliability and performance. Collaborate with cross-functional teams to manage configurations, deployments, and incident...
1 week ago
$155K - $185K *
Transform the technology landscape by leading cross-functional teams to enhance Medicaid Enterprise Systems, driving system architecture improvements and mentoring engineers towards high-quality, secu...
Reposted 1 week ago
IoT Networking Communication Specialist
$80K - $95K *
Lead the charge in advancing IoT solutions by providing expert technical support for industrial connectivity. Collaborate with teams and clients to enhance digital initiatives while ensuring complianc...
Today
Solution Architect, Forward Deployed AI
$135K - $160K *
Transform AI pilots into secure, reliable production systems by designing innovative solutions and collaborating with cross-functional teams to ensure responsible enterprise adoption of AI technologie...
Today
$125K - $150K *
Lead the charge in designing and delivering AI applications on Snowflake, optimizing data governance and architecture. Collaborate with clients and engineers to transform concepts into scalable, secur...
2 weeks ago
$125K - $150K *
Unlock potential by architecting innovative IT solutions that align with client goals. Collaborate with sales teams and engage directly with customers to deliver tailored strategies, ensuring successf...
6 days ago
$155K - $160K *
Shape the future of data solutions by designing scalable architectures that drive AI and analytics initiatives. Collaborate with cross-functional teams to implement innovative strategies that enhance...
1 week ago
Senior Solutions Engineer, Enterprise
$250K - $300K *
Join a team that's redefining enterprise solutions! Leverage your expertise in networking and security to drive technical sales, support customer adoption, and influence product development while coll...
3 weeks ago
Senior Director, Security Architect (USA - Remote)
$160K - $200K *
Reimagine security in cloud systems and software products. Drive architecture, governance, and hands-on implementation for robust security across AI, customer data, and development practices within a...
Reposted 1 week ago
$109K - $150K *
Shape the future of security solutions by guiding complex Managed Services integrations. Collaborate with teams to align customer strategies, mitigate risks, and ensure compliance, while leading techn...
3 weeks ago
Principal / Lead Product Manager, Carrier Connectivity
$135K - $210K *
Lead the charge in solving complex carrier connectivity challenges in commercial insurance. Collaborate with cross-functional teams to streamline workflows and enhance product delivery, ensuring seaml...
Yesterday
AWS Cloud-Native Solution Architect Associate Director
$150K - $375K *
Innovate cutting-edge AWS solutions by leading technical sales, crafting proposals, and collaborating with teams to deliver transformative cloud strategies that meet client needs and drive business su...
2 days ago
AWS Cloud-Native Solution Architect Associate Director
$150K - $375K *
Unlock potential by leading AWS cloud solutions, driving technical sales, and collaborating with teams to deliver innovative, client-focused outcomes. Your expertise will shape proposals and presentat...
3 days ago
Senior Director Analyst - Network Security
$172K - $202K *
Lead innovative insights and strategies as a Senior Director, driving impactful research and analysis to empower clients in navigating complex market challenges and achieving their business objectives...
3 weeks ago
$161K - $190K *
Join us to define and evolve the architecture of a cutting-edge digital platform, guiding engineering decisions and establishing shared services for scalable, secure, and reliable solutions that empow...
5 days ago
$160K - $220K *
Elevate your career by leading the design and deployment of innovative AI solutions. Collaborate with strategic customers to tackle complex data challenges, leveraging graph databases and LLMs to deli...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.