Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$129K - $210K *
Transform issue management by leading a team to develop AI-assisted solutions, ensuring quality and accountability in remediation processes across GRC. Drive engineering excellence while fostering ind...
4 days ago
Senior Director, Site Reliability Engineering
$175K - $250K *
Lead the charge in enhancing the reliability and scalability of a global multi-tenant platform. Drive SRE strategy, foster collaboration across teams, and ensure operational excellence while developin...
5 days ago
Director, Mainframe Systems Programming
$135K - $205K *
Lead the charge in delivering client-focused mainframe solutions. Oversee diverse projects, manage teams, and leverage strategic insights to enhance hardware and software lifecycle management while fo...
3 weeks ago
Manager, Customer Success - Americas
$110K - $130K *
Elevate customer success in the Americas by leading a growing team of CSMs. Drive adoption, value realization, and customer health while shaping playbooks and strategies for scalable growth. Collabora...
4 weeks ago
Ecosystem Operations Specialist
$86K - $146K *
Join us to execute and enhance partner operations, ensuring seamless workflows and data integrity. Collaborate with cross-functional teams to support sales and partners, driving efficiency and operati...
1 week ago
Member of Engineering, Backend - AI
$250K - $250K+*
Pioneer the future of developer AI by architecting scalable backend systems that enhance real-world product experiences through developer-centric cloud infrastructure...
Reposted 3 days ago
IT Systems Engineer Lead - Security
$125K - $135K *
Redefine security monitoring and vulnerability management by leading an Agile team to enhance IT infrastructure security. Collaborate on software design and implementation while ensuring robust remedi...
Yesterday
$80K - $95K *
Drive the execution of large-scale field operations, ensuring projects meet budget, schedule, and safety standards while mentoring team members and fostering strong relationships with clients and part...
Reposted 1 week ago
Strategic Accounts Manager, Data Centers - US Robotics West
$110K - $130K *
Join a pioneering team driving sales growth in the data center segment. You'll develop strategies, manage key accounts, and lead a virtual team to enhance customer satisfaction and deliver value in a...
5 days ago
REMOTE - Principal Platform Software Engineer- Oracle Health
$105K - $234K *
Lead the design and delivery of complex platform capabilities, enhancing reliability and security while mentoring engineers. Collaborate across teams to drive technical excellence and implement AI-ass...
1 week ago
Software Engineer - Data Platform (R37)
$105K - $202K *
Engineer robust data platforms by designing scalable pipelines and APIs that support AI-driven healthcare applications, ensuring high performance, security, and operational excellence in a collaborati...
Reposted today
$150K - $180K *
Elevate data privacy standards by leading a comprehensive privacy program. Collaborate across teams to integrate privacy-by-design principles, enhance data governance, and ensure compliance while enab...
2 weeks ago
Service Delivery Manager - Security & Governance
$150K - $164K *
Lead our cybersecurity and governance initiatives, enhancing security operations and risk management while driving compliance with CMMC 2.0 and ISO/IEC 27001 standards. Collaborate across teams to imp...
1 week ago
Senior Infrastructure & Platform Engineer
$130K - $175K *
Engineer and optimize enterprise platforms for diverse environments, ensuring seamless deployment and support. Collaborate with clients to enhance cybersecurity, compliance, and observability solution...
Reposted 3 days ago
$100K - $120K *
Transform payment strategies by analyzing interchange and routing data to optimize costs and enhance performance. Leverage advanced analytics and automation to deliver actionable insights for stakehol...
4 days ago
$113K - $191K *
Empower innovation in safety technology by developing AI-driven solutions that enhance customer experiences and operational efficiency. Collaborate across teams to deliver scalable, impactful products...
Reposted today
Identity and Access Management Consultant
$63K - $177K *
Shape the future of identity security by implementing IGA solutions, collaborating with clients to enhance access governance, and delivering high-quality results in a dynamic team environment. Your ex...
4 days ago
$116K - $229K *
Transform the customer experience by owning the adoption and success of the Converge Agentic Framework. Collaborate with engineering and product teams to demo capabilities, gather feedback, and drive...
5 days ago
Vice President, Sales - Integrated Solutions
$220K - $275K *
Accelerate growth by leading the demand engine for the Integrated Solutions SBU, driving bookings and revenue across Space and Aerospace & Defense markets while ensuring alignment with strategic goals...
6 days ago
$110K - $130K *
Take ownership of comprehensive cyber risk assessments across the enterprise, articulating risks in business terms to ensure informed decision-making by leadership and helping to strengthen the organi...
Reposted 1 week ago
Director, Operations - Industrial & Manufacturing
$110K - $130K *
Elevate operational excellence by leading project execution, fostering collaboration, and driving performance metrics. Engage with teams to ensure alignment and success from project inception to close...
3 weeks ago
Manager, Operational Technology Infrastructure
$110K - $130K *
Innovate operational technology infrastructure to enhance manufacturing efficiency, ensuring secure and reliable connectivity across all facilities while leading cross-functional collaboration and str...
1 month ago
$110K - $130K *
Innovate and develop complex applications for federal clients, collaborating with teams to ensure high-quality solutions. Utilize modern technologies and best practices to enhance user experience and...
1 week ago
Senior IT Project Manager (NSGS)
$140K - $180K *
Lead the execution of complex IT infrastructure projects, ensuring mission success for critical U.S. Coast Guard programs. Collaborate with stakeholders and manage resources to deliver seamless techno...
6 days ago
$250K - $500K+*
Drive innovation by collaborating with hardware teams to enhance tools, evolve compilers, and improve developer experiences, ensuring efficient and effective hardware design processes...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.