Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Principal AI Cloud Architect – Azure Cloud
$140K - $170K *
Lead the charge in transforming Cloud operations to an AI-first model, guiding a team of engineers to design and deploy AI agents that optimize infrastructure in Azure, while collaborating with client...
Yesterday
$80K - $95K *
Join a team that's dedicated to enhancing business systems integration. Collaborate closely with Accounting to develop and support JD Edwards Orchestrations, leveraging modern technologies and AI tool...
2 weeks ago
Lead Specialist, Technical Architect
$150K - $160K *
Partner with us to shape the quality strategy for a leading exam development platform. Leverage your expertise to guide multiple Agile teams, enhance automation practices, and ensure high standards ac...
Reposted today
$90K - $189K *
Shape the future of network infrastructure by leading modernization efforts across classified and unclassified systems. Collaborate with teams to design secure, high-performance networks while ensurin...
5 days ago
$75K - $158K *
Unlock potential by leading the design, implementation, and optimization of complex network systems. Collaborate on troubleshooting and performance measures to ensure high service levels and complianc...
Reposted 2 weeks ago
Principal Enterprise Architect
$150K - $180K *
Unlock potential by shaping enterprise AI strategy and architecture, driving scalable solutions across applications and data platforms. Collaborate with leaders to ensure responsible AI adoption and g...
2 weeks ago
$120K - $145K *
Elevate your career by leading cloud infrastructure design and automation. As a senior technical leader, you'll mentor engineers, optimize systems, and ensure robust, secure solutions for clients whil...
Today
$160K - $185K *
Join a team that's transforming customer experiences through innovative technical solutions. As a Solutions Architect, you'll bridge business needs with technology, guiding clients from discovery to d...
5 days ago
$110K - $130K *
Drive operational excellence by enhancing reliability and performance of a SaaS platform. Collaborate with development teams to implement automation, incident management, and observability practices...
3 weeks ago
Project Manager, Network Infrastructure
$80K - $120K *
Manage third-party vendors to ensure successful C-Band ground clearing across multiple sites. Oversee project planning, financial tracking, and compliance documentation to meet FCC requirements and de...
Yesterday
Principal AI Security Engineer
$172K - $240K *
Join a team that's redefining AI security! As a Principal AI Security Engineer, you'll lead assessments, design controls, and partner with teams to ensure safe AI adoption across the enterprise, drivi...
3 weeks ago
$190K - $200K *
Lead the charge in electrical engineering excellence across multiple campuses, ensuring robust design, validation, and energization of critical infrastructure while integrating onsite generation solut...
3 weeks ago
Consulting Solution Architect - NetApp
$121K - $170K *
Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...
4 days ago
$145K - $175K *
Join a team that's redefining cloud solutions by architecting innovative CaaS and cloud-native technologies. Collaborate with customers to tackle complex challenges and drive successful cloud transfor...
2 weeks ago
Director, Rack Scale Software Architecture
$320K - $488K *
Join a team that's pushing the boundaries of innovation in rack-scale system software. Lead technical design efforts, collaborate with top industry players, and drive quality across a rapidly evolving...
Reposted 1 week ago
Security & Infrastructure Engineer
$100K - $120K *
Drive security excellence by managing identity access, external testing, and compliance processes. Collaborate with teams to enhance AWS security and develop scalable policies, ensuring robust protect...
3 weeks ago
$100K - $120K *
Join a dynamic team as you guide school districts in crafting effective solution strategies. Collaborate with sales and product teams to enhance educational outcomes through tailored technology soluti...
4 days ago
$135K - $149K *
Analyze and enhance IT infrastructure through secure cloud solutions, ensuring 24x7 availability. Collaborate with teams to streamline workflows, improve system reliability, and tackle complex challen...
Yesterday
$100K - $120K *
Lead the charge in managing a high-performing team of facility technicians, ensuring operational excellence and compliance while fostering a culture of safety and teamwork in a critical environment...
3 weeks ago
General Manager, Data Center (New Build)
$240K - $300K *
Champion the operational excellence of a gigawatt-scale data center, leading a diverse team to ensure seamless deployment, readiness, and performance. Drive innovation and efficiency while collaborati...
3 weeks ago
$110K - $130K *
Engage with sales teams to identify prospects and demonstrate solutions that enhance organizational security. Educate clients on challenges and drive meetings to provide tailored solutions, ensuring e...
2 weeks ago
Cybersecurity Architect - Remote
$99K - $109K *
Elevate enterprise cybersecurity by designing robust architectures that protect IT and industrial environments. Collaborate with cross-functional teams to identify vulnerabilities and implement effect...
4 days ago
$105K - $115K *
Optimize security measures by leading technical solutions to mitigate information risks. Ensure compliance with corporate policies and oversee incident response, safeguarding all computing platforms a...
3 weeks ago
Enterprise Architect - Oracle CX, ERP, HCM & SCM
$135K - $160K *
Lead enterprise architecture strategy across Oracle CX, ERP, HCM, and SCM Cloud. Collaborate with stakeholders to develop scalable solutions, ensuring alignment with business capabilities and technolo...
1 week ago
$167K - $223K *
Champion innovative cloud financial strategies by leading data-driven architecture within a dynamic multi-cloud ecosystem, enhancing accountability, performance, and cost efficiency to drive business...
Reposted 3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.