Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$169K - $254K *
Lead and optimize the Solutions Engineering team in the Healthcare sector, focusing on technical sales and strategic planning. Drive team performance, manage recruitment, and ensure alignment with com...
6 days ago
$140K - $175K *
Join a team that's shaping security and compliance across the company. You'll lead HITRUST and SOC 2 programs, ensuring data protection while collaborating with engineering and legal teams in a hands...
Yesterday
$63K - $129K *
Support and enhance IT networks by troubleshooting, maintaining, and integrating systems. Collaborate with teams to ensure seamless operations and provide guidance to junior staff while managing netwo...
Reposted 2 weeks ago
Principal Technologist - AI and Data Center Networking
$160K - $200K *
Shape the future of data center networking as a Principal Technologist, leading complex pre-sales engagement and architecture for AI infrastructure. Collaborate with top industry players to innovate s...
Reposted 1 week ago
$116K - $125K *
Elevate cybersecurity measures by designing and implementing robust controls for enterprise applications and infrastructure. Collaborate with cross-functional teams to ensure compliance with federal s...
1 week ago
Sr. Systems Engineer, ProAV - North Central
$110K - $130K *
Lead the charge in delivering technical expertise for ProAV solutions, ensuring successful customer onboarding, advanced troubleshooting, and pre-sales support across the North Central U.S. while enga...
2 weeks ago
Software Engineer, Identity Platform
$125K - $150K *
Join a team that's redefining identity management across diverse platforms. You'll architect secure authentication and authorization systems, ensuring seamless access for users and organizations while...
2 weeks ago
$173K - $198K *
Lead the evolution of data architecture, driving real-time capabilities and AI integration. Collaborate with executives and teams to enhance data quality, governance, and scalability while mentoring a...
1 week ago
Staff Systems Engineer - Architecture & Interfaces
$165K - $220K *
Join a team that's redefining avionics systems engineering by translating customer needs into innovative architectures and requirements. Collaborate across domains to deliver high-quality solutions in...
5 days ago
$100K - $170K *
Unlock potential by providing architectural engineering support for DOJ/BOP facilities. Collaborate on technical analyses, document reviews, and design recommendations to enhance decision-making and p...
3 weeks ago
Distinguished Architect - Asset and Infrastructure Transformation - Remote
$179K - $232K *
Shape the future of technology architecture by leading complex initiatives, aligning enterprise strategies, and driving innovation across multiple domains to enhance operational efficiency and busines...
3 days ago
$112K - $137K *
Join a team that's dedicated to optimizing enterprise network infrastructure. This role involves designing, implementing, and maintaining secure, high-performing networks across diverse environments...
Today
$160K - $185K *
Lead the charge in designing Azure platforms for healthcare data products, ensuring resilience, security, and cost management while mentoring engineers and shaping architectural standards in a fully r...
1 week ago
Principal Solution Architect (Azure)
$145K - $175K *
Transform your career by leading architectural design and implementation for innovative solutions. Collaborate with engineers to create scalable, efficient systems in Azure, leveraging modern technolo...
2 weeks ago
Principal Solution Architect (Azure)
$145K - $175K *
Empower innovation as a Principal Solution Architect, designing scalable, cost-efficient solutions in Azure. Collaborate with engineers to create robust architectures and reference implementations, dr...
2 weeks ago
Mainframe Modernization Architect
$156K - $210K *
Champion transformative solutions by leveraging your extensive expertise in mainframe modernization. Collaborate with global clients to drive innovation, enhance technology strategies, and ensure seam...
4 weeks ago
$146K - $234K *
Transform the future of banking by architecting scalable API solutions. Lead integration strategies, optimize performance, and collaborate across teams to enhance the Federal Reserve's technology land...
2 weeks ago
$146K - $234K *
Transform your career by leading API management and integration strategies. Leverage your expertise in software architecture to design scalable solutions, ensuring security and efficiency across the F...
2 weeks ago
$80K - $95K *
Optimize network infrastructure within the DHMS program, ensuring reliability, performance, and security. Collaborate with IT teams to develop policies, troubleshoot issues, and maintain compliance wi...
5 days ago
$150K - $180K *
Drive your career as a Compliance Architect, guiding clients through CMMC compliance journeys. Collaborate with stakeholders to assess risks, develop strategic roadmaps, and ensure alignment with regu...
Reposted 1 week ago
Network Security & SASE Architect - Palo Alto Networks Senior Manager
$122K - $338K *
Drive innovative network security solutions by leading transformation programs, engaging with executives, and architecting robust security frameworks. Collaborate with teams to enhance enterprise secu...
5 days ago
$135K - $160K *
Lead the charge in designing cutting-edge infrastructure for large-scale AI deployments. Collaborate with multidisciplinary teams to ensure seamless execution from concept to construction, maintaining...
2 weeks ago
Remote Endpoint Engineering Senior Systems Architect (VA ESOM)
$145K - $185K *
Lead enterprise-level architectural initiatives to enhance endpoint technologies, guiding modernization efforts and integrating emerging solutions across multiple divisions while ensuring security and...
2 weeks ago
$150K - $180K *
Lead the charge in designing a cutting-edge platform for modern data centers, integrating AI and cloud technologies. Collaborate with cross-functional teams to build a robust, scalable architecture th...
6 days ago
Enterprise Architect - Hybrid (LOCAL CANDIDATES ONLY, - DALLAS, TX)
$130K - $155K *
Join a dynamic team to define and implement enterprise architecture frameworks that align technology solutions with strategic IT objectives, ensuring security, scalability, and operational efficiency...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.