Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$169K - $254K *

Lead and optimize the Solutions Engineering team in the Healthcare sector, focusing on technical sales and strategic planning. Drive team performance, manage recruitment, and ensure alignment with com...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $175K *

Join a team that's shaping security and compliance across the company. You'll lead HITRUST and SOC 2 programs, ensuring data protection while collaborating with engineering and legal teams in a hands...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$63K - $129K *

Support and enhance IT networks by troubleshooting, maintaining, and integrating systems. Collaborate with teams to ensure seamless operations and provide guidance to junior staff while managing netwo...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $200K *

Shape the future of data center networking as a Principal Technologist, leading complex pre-sales engagement and architecture for AI infrastructure. Collaborate with top industry players to innovate s...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$116K - $125K *

Elevate cybersecurity measures by designing and implementing robust controls for enterprise applications and infrastructure. Collaborate with cross-functional teams to ensure compliance with federal s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in delivering technical expertise for ProAV solutions, ensuring successful customer onboarding, advanced troubleshooting, and pre-sales support across the North Central U.S. while enga...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Join a team that's redefining identity management across diverse platforms. You'll architect secure authentication and authorization systems, ensuring seamless access for users and organizations while...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$173K - $198K *

Lead the evolution of data architecture, driving real-time capabilities and AI integration. Collaborate with executives and teams to enhance data quality, governance, and scalability while mentoring a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into innovative architectures and requirements. Collaborate across domains to deliver high-quality solutions in...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$100K - $170K *

Unlock potential by providing architectural engineering support for DOJ/BOP facilities. Collaborate on technical analyses, document reviews, and design recommendations to enhance decision-making and p...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$179K - $232K *

Shape the future of technology architecture by leading complex initiatives, aligning enterprise strategies, and driving innovation across multiple domains to enhance operational efficiency and busines...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Transportation

$112K - $137K *

Join a team that's dedicated to optimizing enterprise network infrastructure. This role involves designing, implementing, and maintaining secure, high-performing networks across diverse environments...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$160K - $185K *

Lead the charge in designing Azure platforms for healthcare data products, ensuring resilience, security, and cost management while mentoring engineers and shaping architectural standards in a fully r...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$145K - $175K *

Transform your career by leading architectural design and implementation for innovative solutions. Collaborate with engineers to create scalable, efficient systems in Azure, leveraging modern technolo...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$145K - $175K *

Empower innovation as a Principal Solution Architect, designing scalable, cost-efficient solutions in Azure. Collaborate with engineers to create robust architectures and reference implementations, dr...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$156K - $210K *

Champion transformative solutions by leveraging your extensive expertise in mainframe modernization. Collaborate with global clients to drive innovation, enhance technology strategies, and ensure seam...

United StatesRemote

4 weeks ago

  •   15+ years exp.  •   Information Technology

$146K - $234K *

Transform the future of banking by architecting scalable API solutions. Lead integration strategies, optimize performance, and collaborate across teams to enhance the Federal Reserve's technology land...

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$146K - $234K *

Transform your career by leading API management and integration strategies. Leverage your expertise in software architecture to design scalable solutions, ensuring security and efficiency across the F...

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Optimize network infrastructure within the DHMS program, ensuring reliability, performance, and security. Collaborate with IT teams to develop policies, troubleshoot issues, and maintain compliance wi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive your career as a Compliance Architect, guiding clients through CMMC compliance journeys. Collaborate with stakeholders to assess risks, develop strategic roadmaps, and ensure alignment with regu...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$122K - $338K *

Drive innovative network security solutions by leading transformation programs, engaging with executives, and architecting robust security frameworks. Collaborate with teams to enhance enterprise secu...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$135K - $160K *

Lead the charge in designing cutting-edge infrastructure for large-scale AI deployments. Collaborate with multidisciplinary teams to ensure seamless execution from concept to construction, maintaining...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $185K *

Lead enterprise-level architectural initiatives to enhance endpoint technologies, guiding modernization efforts and integrating emerging solutions across multiple divisions while ensuring security and...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in designing a cutting-edge platform for modern data centers, integrating AI and cloud technologies. Collaborate with cross-functional teams to build a robust, scalable architecture th...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $155K *

Join a dynamic team to define and implement enterprise architecture frameworks that align technology solutions with strategic IT objectives, ensuring security, scalability, and operational efficiency...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.