Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Data Engineer - Data Platform
$130K - $160K *
Champion the migration to a modern Databricks lakehouse, designing robust data pipelines and ensuring data quality. Collaborate with teams to enhance analytics capabilities and set technical standards...
2 weeks ago
$110K - $130K *
Join a dynamic team as a Strategic Sales Engineer, driving sales growth through technical expertise and collaboration. Engage with sales leadership to create opportunities and deliver solutions across...
6 days ago
Director, Client Coding Integration
$97K - $145K *
Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...
5 days ago
Director, Client Coding Integration
$120K - $145K *
Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...
Reposted 2 weeks ago
Senior Technology & Systems Consultant
$130K *
Join a dynamic team to manage client technologies, mentor peers, and deliver IT assessments. This hands-on role emphasizes client service and consultant development, ensuring optimal performance acros...
1 week ago
Azure Application Engineering Lead
$125K - $150K *
Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...
1 week ago
$75K - $158K *
Empower your career by joining a dynamic team focused on enhancing IT operations. Leverage your expertise in Momentum Financials to drive impactful solutions and collaborate with stakeholders in a hig...
Today
Forward Deployed Full Stack Engineer (Active Secret Clearance)
$120K - $145K *
Drive impactful software solutions by embedding with clients, transforming ambiguous needs into deployable features across secure environments. Collaborate closely with users and stakeholders to deliv...
Reposted 4 days ago
Senior Channel Sales Engineer - Guidepoint & Regionals
$110K - $149K *
Elevate your career by collaborating with top partners to drive technical sales, deliver impactful training, and enhance product adoption. Join a dynamic team focused on fostering creativity and accou...
6 days ago
Director of Strategic Accounts (U.S. Mid-Atlantic Education)
$139K - $213K *
Join a team that's driving innovation in education technology by generating strategic opportunities and delivering tailored solutions to key decision-makers in the Mid-Atlantic region, ensuring except...
Yesterday
Principal Operational Technology, Telemetry and SCADA Engineer
$169K - $253K *
Transform operational technology by leading the design and implementation of scalable SCADA and telemetry solutions, ensuring secure data delivery and operational visibility across multi-site environm...
3 weeks ago
Oracle HCM Technical Architect
$120K - $145K *
Transform client experiences by leading the design and implementation of Oracle HCM Cloud solutions. Collaborate with teams to ensure scalable, reliable, and high-performance technical architectures t...
Reposted today
Principal Platform/Software Engineer
$150K - $180K *
Lead the charge in designing and implementing innovative software systems for cutting-edge healthcare SaaS platforms, driving technical excellence and strategic collaboration across teams to achieve i...
Reposted 2 weeks ago
VP Business Development- Heavy Systems Manufacturing
$160K - $200K *
Unlock potential by leading business development for Heavy Systems Manufacturing, driving profitable bookings and strategic customer engagement while collaborating across departments to ensure operati...
Reposted 1 week ago
Senior/Staff Attack Engineer, Rapid Response
$230K - $275K *
Lead the charge in vulnerability research and exploitation techniques, transforming real-world threats into automated solutions. Collaborate with teams to enhance security measures and validate defens...
3 weeks ago
Sr. Manager, Enterprise Cyber Defense
$181K - $301K *
Transform your career by leading a global cyber defense team, driving proactive strategies to mitigate risks and enhance security across diverse environments. Collaborate with cross-functional teams t...
Reposted 2 weeks ago
Director, Software Engineering (Account Servicing & Finance)
$150K - $180K *
Unlock potential by leading software engineering teams to deliver scalable solutions. Drive strategic partnerships, enhance engineering practices, and foster a culture of innovation and accountability...
Yesterday
$120K - $145K *
Transform the engineering landscape by owning architecture, deployment, and incident management. Collaborate with teams to prioritize features, enhance payment systems, and integrate AI, all while ens...
Today
$80K - $155K *
Join a team that's redefining energy solutions by designing innovative fluid and power systems. As a Process Engineer, you'll drive the development and optimization of cutting-edge technologies in a f...
2 weeks ago
Director of Enterprise Sales - Remote
$114K - $200K *
Champion growth by leading the Enterprise Sales team, driving member acquisition, and executing strategic sales initiatives in the cybersecurity sector. Collaborate with stakeholders to enhance sales...
6 days ago
$110K - $130K *
Lead the charge in transforming client operations by identifying and accelerating AI-driven opportunities. Collaborate with stakeholders to frame business challenges, prototype solutions, and drive me...
Reposted 1 week ago
$80K - $95K *
Engage in strategic proposal management, leading RFQ/RFP responses across divisions. Collaborate with teams to ensure timely, compliant submissions while maintaining high-quality standards and support...
3 weeks ago
Federal Solutions Architect (Remote Opportunity)
$120K - $145K *
Drive innovative solutions by architecting complex enterprise technologies for federal healthcare, focusing on VA and other agencies. Collaborate across teams to translate requirements into scalable...
3 weeks ago
$140K - $180K *
Innovate with us as you lead technical delivery for enterprise data integration and migration projects, focusing on Higher Education and Salesforce ecosystems. Drive solution architecture, manage team...
3 weeks ago
North America Digital Solutions Key Account Director
$150K - $180K *
Inspire growth by leading strategic initiatives for key telecom accounts, fostering executive relationships, and driving multi-year revenue plans. Collaborate across teams to align solutions with evol...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.