Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$140K - $220K *
Champion the evolution of scalable infrastructure in a multi-cloud environment, collaborating with engineering teams to enhance reliability and performance for AI-driven healthcare solutions...
4 days ago
Senior Backend Engineer, Onboarding and Provisioning
$199K - $235K *
Lead the charge in building robust backend services that streamline customer onboarding and provisioning workflows, ensuring seamless activation and reliable integrations across teams for optimal user...
4 days ago
$100K - $120K *
Drive efficiency and scalability in legal operations by optimizing processes, managing technology, and controlling costs. Lead cross-functional projects and enhance compliance initiatives to support t...
5 days ago
Senior Manager, Cloud Infrastructure
$170K - $190K *
Lead and innovate within UJET's Core Infrastructure team, focusing on cloud-native services. Shape strategies for scalable solutions that empower engineers and optimize the infrastructure for thousand...
Reposted 1 week ago
CAD Systems Manager (Civil 3D)
$95K - $115K *
Drive the enhancement of design efficiency and best practices in CAD systems, focusing on AutoCAD Civil 3D. Lead standards development, training, and workflow optimization across multiple states to en...
3 weeks ago
Software Engineer - CeFi Integrations Team
$95K - $115K *
Accelerate development in a fast-paced environment by enhancing and building integrations on the CoinLedger platform, collaborating with a dedicated team to improve user experience and operational eff...
Reposted 3 weeks ago
Senior - Administrative Assistant
$63K - $111K *
Join a team that's dedicated to providing top-notch administrative support to program leadership and project personnel, ensuring smooth operations and effective communication across multidisciplinary...
1 week ago
$110K - $130K *
Transform your career by driving customer success and technical solutions. Collaborate with cross-functional teams to enhance client relationships, identify growth opportunities, and ensure maximum va...
1 week ago
$120K - $140K *
Lead the design and optimization of hybrid infrastructure, focusing on Microsoft Azure and Microsoft 365. Ensure secure, scalable, and reliable technology solutions that align with business needs whil...
Today
Staff Software Development Engineer
$152K - $190K *
Develop high-performance networking solutions using Rust for a secure client connector. Collaborate with cross-functional teams to enhance code quality and implement impactful features while addressin...
4 weeks ago
Product Engineer II - Web Services
$79K - $133K *
Elevate progress at the forefront of ArcGIS Hub by transforming customer workflows, communicating priorities, and enhancing geospatial collaboration through innovative product management...
Reposted today
Data Platform Engineer, Senior
$77K - $176K *
Empower your career as a senior platform engineer, leveraging cloud technologies to enhance data environments. Collaborate with cross-functional teams to drive strategy, design, and implementation of...
5 days ago
$165K - $205K *
Lead the charge in cybersecurity governance and risk management consulting. Drive client engagements, develop security frameworks, and mentor teams while ensuring alignment with industry standards and...
3 weeks ago
$125K - $225K *
Create innovative data solutions by designing scalable pipelines and AI tools. Collaborate with cross-functional teams to enhance data quality and security, driving impactful analytics and machine lea...
1 week ago
$86K - $119K *
Lead the charge in building and supporting enterprise data solutions that transform business requirements into scalable models, enhancing analytics and reporting capabilities across the organization...
Today
$68K - $143K *
Analyze and reengineer business processes to enhance operational efficiency, collaborating with stakeholders to ensure alignment with strategic goals and regulatory requirements while supporting syste...
1 week ago
Sr. Manager, Analyst Relations
$165K - $190K *
Advance your career by shaping analyst relations and market perception in AI and automation. Collaborate with cross-functional teams to drive impactful evaluations and strategic narratives that enhanc...
2 weeks ago
Director, Professional Services - Cybersecurity
$160K - $175K *
Transform cybersecurity professional services by leading delivery execution, ensuring quality, and developing talent. Collaborate with cross-functional teams to enhance service capabilities and drive...
2 weeks ago
$160K - $230K *
Elevate your career by owning the infrastructure and security of a multi-environment platform. Collaborate with leadership to build and operate systems that support critical government operations and...
Today
Account Executive, Commercial West
$300K - $350K *
Lead the charge in driving enterprise revenue across the West territory, engaging with senior security leaders in regulated industries. Shape strategic sales initiatives and build lasting relationship...
Reposted today
$115K - $154K *
Elevate your career with a dynamic role in full-stack Java development, focusing on scalable applications and cloud solutions. Collaborate in an Agile environment to drive innovation and modernization...
Yesterday
Security Engineer - DLP and Insider threat
$105K - $149K *
Drive security excellence by enhancing data protection and detection capabilities. Collaborate with cross-functional teams to implement DLP policies, automate processes, and ensure enterprise systems...
Reposted 4 days ago
Application Engineer - RF Test, AZ
$115K - $190K *
Join a team that's dedicated to solving complex RF and Microwave challenges. Collaborate with engineers and scientists to deliver innovative solutions, provide technical support, and enhance customer...
4 days ago
Data Center Operations Technician
$130K - $170K *
Join a team that's redefining acquisition strategies and program management. Leverage your expertise to advise on budgeting, scheduling, and execution while developing comprehensive plans and document...
4 days ago
$190K - $267K *
Shape the future of app advertising by enhancing backend systems for conversion signals. Drive MMP integrations, SKAN processing, and App CAPI to ensure reliable app installs and in-app events for adv...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.