Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Provisioner Specialist- REMOTE
$70K - $105K *
Optimize provisioning strategies for mission-critical SATCOM systems. Collaborate with cross-functional teams to ensure operational readiness and minimize downtime through effective logistics support...
4 days ago
$95K - $115K *
Join a team that's dedicated to overseeing data center operations, ensuring project completion, and fostering strong client relationships. This role demands technical expertise and collaboration to ma...
5 days ago
$120K - $145K *
Empower your career by leading data architecture initiatives across Oracle Cloud applications. Drive data governance, migration, and integration strategies to enhance business processes and ensure dat...
Reposted today
$88K - $105K *
Join our team to lead IT projects that enhance technology and optimize processes. Collaborate across functions to drive improvements, ensuring alignment with business goals while fostering a culture o...
6 days ago
Vice President of Data Engineering - Hospital Systems
$297K - $367K *
Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...
Reposted today
$89K - $165K *
Engage in complex engineering design and analysis, tackling technical challenges and enhancing product development. Collaborate across teams to drive innovation and ensure quality in high voltage syst...
6 days ago
$89K - $165K *
Shape innovative engineering solutions by applying advanced design techniques and conducting complex analyses. Collaborate with cross-functional teams to enhance product development and ensure high-qu...
1 week ago
$89K - $165K *
Engineer innovative solutions by applying advanced design techniques to complex electrical systems, conducting technical analyses, and collaborating with cross-functional teams to enhance product deve...
1 week ago
Lead Cloud Solution Architect- AI & Data (AWS)
$140K - $175K *
Drive the development of innovative AI and data solutions, enhancing enterprise data platforms while ensuring scalable, quality delivery. Collaborate with teams to define technical architecture, shapi...
Reposted 4 weeks ago
$95K - $115K *
Lead the charge in preconstruction activities for major commercial projects, overseeing budgeting, scheduling, and subcontractor evaluation. Foster team development and strong relationships across all...
Reposted 4 weeks ago
$115K - $130K *
Join a dynamic team as you provide essential IT support to a distributed workforce. Leverage your troubleshooting skills to resolve technical issues, enhance user experience, and contribute to a colla...
Reposted 1 week ago
Security Consultant - Hardware Specialist
$100K - $120K *
Join a team that's passionate about security innovation, focusing on penetration testing and threat modeling across diverse technologies. Leverage your expertise in software and hardware analysis to t...
Yesterday
Director, Deployment Strategy and Integration
$170K - $220K *
Drive your career forward by leading cross-functional deployment strategies. This senior role requires exceptional judgment and communication skills to navigate complex, ambiguous situations and deliv...
6 days ago
Senior Cyber Security Engineer
$110K - $130K *
Transform cybersecurity practices by leading vulnerability management and penetration testing efforts. Collaborate with cross-functional teams to enhance security controls, reduce risks, and ensure ro...
6 days ago
$120K - $145K *
Champion security excellence by leading complex Microsoft Sentinel and Defender XDR implementations. Drive technical enablement projects, mentor engineers, and enhance client security practices in a d...
2 weeks ago
$88K - $105K *
Lead and manage complex multidisciplinary design projects, ensuring high-quality execution and fostering strong client relationships. Collaborate with diverse teams to deliver on time and within budge...
4 weeks ago
$110K - $130K *
Unlock potential by designing and managing Azure infrastructure, ensuring seamless hybrid connectivity and robust disaster recovery. Collaborate across teams to enhance operations, automate processes...
2 weeks ago
$195K - $325K *
Join a team that's shaping the future of AI in healthcare by leading multi-year strategies, resolving complex technical challenges, and influencing executive decisions across the organization to ensur...
1 week ago
Senior DevSecOps Engineer (TS/SCI)
$140K - $200K *
Lead the charge in optimizing our OpenShift platform, leveraging your DevSecOps expertise to enhance operations and support national security efforts. Collaborate with multidisciplinary teams to craft...
Today
$88K - $105K *
Join a team that's dedicated to delivering high-quality design-build projects. As a Senior Project Engineer, you'll oversee project execution, mentor junior staff, and ensure timely completion from de...
2 weeks ago
Software Engineer, Integrations (US + Calgary)
$140K - $160K *
Accelerate progress at our integration platforms, ensuring scalable, reliable data flows. You'll design, build, and optimize workflows while collaborating across teams to enhance performance and custo...
1 week ago
$74K - $87K *
Transform client implementations by leading discovery, planning, and execution. Own project scope, timelines, and budgets to ensure successful adoption of solutions that align with business goals and...
4 days ago
Business Development Director, DOE
$157K - $283K *
Lead the charge in driving business growth by developing strategic partnerships and innovative solutions for federal clients, while collaborating with cross-functional teams to deliver exceptional res...
1 week ago
$144K - $200K *
Unlock potential by managing end-to-end technical deployments of computer vision systems. Collaborate with clients in diverse environments to ensure seamless production operations and enhance system p...
Reposted 3 days ago
Senior Full Stack Software Engineer (Go, AWS, GCP)
$165K - $260K *
Drive the development of an intelligent content delivery network, optimizing web performance through cutting-edge infrastructure and AI. Collaborate with a lean team to transform complex problems into...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.