Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$95K - $115K *

Lead the design and maintenance of robust network solutions, ensuring optimal performance and security across Local and Wide Area Networks. Collaborate with teams to implement innovative technologies...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Shape the future of network solutions by maintaining and enhancing LAN/WAN operations. Collaborate on innovative architectures to boost efficiency, security, and scalability while ensuring compliance...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Lead the design and maintenance of Local and Wide Area Networks, enhancing efficiency and security. Collaborate on innovative solutions and ensure network reliability while adhering to industry standa...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$168K - $240K *

Champion AI strategy and governance by leading advisory consulting services, guiding clients from interest to practical adoption. Collaborate with technical teams to deliver integrated solutions and e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $185K *

Reimagine legal workflows as an AI Solutions Architect, driving AI adoption in law firms. Collaborate with teams to design and implement innovative solutions, enhancing efficiency and client advocacy...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$150K - $180K *

Join us to tackle complex challenges as a strategic technical leader, influencing product direction and driving customer success. Your expertise will shape innovative solutions while engaging directly...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$320K - $405K *

Design and oversee the electrical architecture for cutting-edge data centers, ensuring robust power distribution and integration of advanced technologies. Collaborate with partners to enhance prefabri...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $251K *

Pioneer innovative technology strategies and architectural solutions across Agile teams, driving AI-enabled engineering transformation and ensuring scalable, secure, and maintainable solutions for ent...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $212K *

Elevate AI security by designing robust frameworks to protect systems from threats. Collaborate with cross-functional teams to ensure compliance and ethical use, while implementing strategies that saf...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$150K - $160K *

Unlock potential by designing and optimizing enterprise database environments for mission-critical HRIT applications, ensuring security, scalability, and compliance with federal standards while collab...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $170K *

Unlock the potential of enterprise data architecture by designing secure, scalable solutions for employee data using Databricks. Collaborate with cross-functional teams to implement governance, compli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$115K - $150K *

Architect and streamline cloud network infrastructure. Support robust security and connectivity across Azure, OpenShift, and SASE platforms. Collaborate with cross-functional teams, ensuring optimal p...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$103K - $154K *

Unlock advanced data solutions by leveraging Microsoft Azure and Power BI. Collaborate with teams to deliver high-quality analytics and reporting, while enhancing business intelligence capabilities th...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Optimize cloud operations by managing Azure and AWS environments, ensuring reliability, performance, and security. Leverage modern IaC and AI tools to enhance workload efficiency and operational excel...

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$116K - $155K *

Transform the future of healthcare IT by designing scalable, secure database architectures that enhance medical imaging solutions. Collaborate across teams to ensure high-performance systems that supp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $214K *

Shape enterprise data architectures by leveraging your expertise in Databricks and modern cloud platforms. Collaborate with clients to design scalable solutions that drive analytics, AI/ML, and data g...

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $140K *

Innovate cloud solutions by designing and automating infrastructure in Cloud.gov and Azure. Collaborate with teams to enhance performance and security, driving impactful results for clients while shap...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$155K - $210K *

Empower your career by leading enterprise database architecture and transformation initiatives. Collaborate with executive stakeholders to drive innovation and establish best practices in modern data...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Drive innovative system designs for security, video, access, and fire alarm solutions. Collaborate with teams to deliver tailored solutions, support junior members, and ensure project success through...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$88K - $105K *

Innovate and lead architectural projects from concept to completion, ensuring timely delivery and client satisfaction. Collaborate with diverse teams, manage budgets, and mentor junior staff while mai...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$114K - $182K *

Analyze competitive landscapes in ITDC technologies, providing strategic insights and support across functions to enhance market positioning and respond to emerging threats effectively...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$130K - $155K *

Shape the future of intelligence analysis by providing strategic leadership in geospatial, AI, and ML technologies. Drive modernization and operational efficiency through innovative solutions and agil...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Shape the future of procurement by leading SAP S/4HANA and Ariba implementations, optimizing processes, and driving transformation initiatives within a collaborative ERP Center of Excellence...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$169K - $254K *

Lead and optimize the Solutions Engineering team in the Healthcare sector, focusing on technical sales and strategic planning. Drive team performance, manage recruitment, and ensure alignment with com...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.