Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Software Engineer, Observability
$120K - $145K *
Champion the development of innovative observability solutions, leveraging your expertise in Go and network protocols to enhance network automation. Collaborate with cross-functional teams to deliver...
4 weeks ago
Electrical OFCI Design Manager - Data Center Construction
$170K - $210K *
Lead the design management of owner-furnished electrical equipment for a hyperscale data center, ensuring integration, compliance, and quality standards while guiding teams and managing client communi...
Yesterday
Electrical OFCI Design Manager - Data Center Construction
$170K - $210K *
Lead the charge in managing design and coordination of OFCI electrical systems for a hyperscale data center. Drive project success through strategic oversight, team leadership, and client engagement w...
6 days ago
Software Engineer (Technical Leadership) - Central Growth
$175K - $210K *
Innovate and lead the technical vision for large-scale product systems, driving cross-functional initiatives and engineering excellence while mentoring teams to enhance growth and impact across multip...
2 weeks ago
Practice Lead, Cloud and Data Center
$125K - $150K *
Lead and manage the Cloud & Data Center team, ensuring successful project execution and operational excellence while mentoring engineers and driving technical standards across cloud and virtualization...
1 week ago
Enterprise Architect - Emerging Analytics
$134K - $209K *
Join a team that's redefining data architecture and analytics. Leverage your expertise to drive cloud adoption, modernize data platforms, and influence strategic initiatives that empower data-driven d...
4 weeks ago
$125K - $150K *
Join a team that's redefining asset management through innovative Oracle ERP solutions. Lead enterprise-level systems engineering to enhance financial accuracy and streamline processes, ensuring compl...
6 days ago
$95K - $115K *
Shape the future of financial operations by owning and modernizing financial systems, automating processes, and collaborating with engineering to streamline integrations for enhanced efficiency and re...
Reposted 6 days ago
CGI OpenGrid Implementation Analyst, Sr. Associate
$77K - $202K *
Lead the charge in implementing CGI OpenGrid solutions, analyzing client needs, and guiding junior team members while enhancing operational efficiency through innovative business software solutions...
3 days ago
Lead Process Mechanical Engineer
$110K - $130K *
Champion process engineering excellence in petfood and meat production. Lead design projects, collaborate across teams, and ensure safe, innovative solutions that support client goals. Ideal for entre...
Reposted 2 weeks ago
Lead Platform Engineer, AI and DevSecOps
$155K - $175K *
Empower engineering teams by leading the evolution of cloud, security, and AI operations. Drive platform reliability and DevSecOps practices while mentoring others to foster a collaborative, innovativ...
3 weeks ago
WMS Solution Architect Manager
$141K - $278K *
Lead the charge in transforming supply chain strategies, enhancing operational efficiency, and implementing advanced solutions. Collaborate with clients to deliver innovative insights and drive compet...
6 days ago
Offensive Security Technical Lead
$105K - $231K *
Drive offensive security initiatives by leading penetration testing and red-team efforts. Own complex technical engagements, ensuring robust assessments and impactful remediation strategies for federa...
Reposted 2 weeks ago
$120K - $145K *
Take ownership of automating workflows across teams by building AI agents using Claude and Microsoft Copilot. Collaborate with various departments to identify automation opportunities, ensuring securi...
3 weeks ago
Transportation CAD Designer - OpenRoads
$74K - $130K *
Elevate your career by leading design efforts in transportation projects, utilizing OpenRoads Designer. Collaborate with engineers to deliver high-quality solutions while ensuring compliance with stan...
3 weeks ago
Intranet Account Executive - Remote
$110K - $130K *
Unlock your potential by driving sales of innovative Employee Comms solutions. Collaborate with partners and peers to enhance customer engagement and revenue growth while showcasing your expertise in...
2 weeks ago
$115K - $172K *
Join a team that's driving strategic sales in cyber security and networking. Leverage your expertise to manage key accounts, develop relationships, and achieve revenue goals while navigating complex b...
2 weeks ago
Google Cloud & Gemini Enterprise Administrator
$110K - $130K *
Champion the administration of Google Cloud and Gemini Enterprise environments, ensuring secure, scalable configurations. Collaborate with IT and business teams to optimize cloud services and support...
4 weeks ago
Principal Technical Program Manager, Engineering
$180K - $240K *
Drive cross-domain visibility and coordination in a dynamic engineering environment. As the sole TPM, you'll ensure programs are on track, dependencies are mapped, and automation enhances efficiency a...
6 days ago
Senior/Staff Software Engineer (Platform and Execution Model)
$180K - $240K *
Transform the future of distributed systems by designing and building robust platform components. Collaborate with teams to ensure reliability and scalability in mission-critical environments, driving...
3 weeks ago
$120K - $170K *
Transform enterprise software systems by leading design and development efforts, ensuring scalable, secure applications that meet federal mission needs while mentoring engineers and driving best pract...
1 week ago
Operational Technology (OT) Engineer
$76K - $118K *
Explore a pivotal role in enhancing operational technology solutions for Army facilities. Collaborate with diverse teams to ensure system security, reliability, and compliance while supporting moderni...
2 weeks ago
$100K - $120K *
Drive the development and integration of advanced nuclear energy systems by applying systems engineering methods to translate objectives into clear, verifiable requirements and solutions, while collab...
1 week ago
Salesforce Architect | Public Health | Public Sector
$145K - $150K *
Grow your career with a collaborative team focused on public health solutions. As a Senior Salesforce Developer, you'll leverage your expertise to enhance health department systems nationwide within a...
1 week ago
$120K - $140K *
Drive the development and optimization of GTM strategies, leveraging automation and campaign execution across multiple platforms to enhance pipeline generation and account prioritization in a dynamic...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.