Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$100K - $120K *

Optimize integration processes by bridging technical gaps between systems. Collaborate with campus IT to ensure seamless data flows, troubleshoot issues, and enhance integration reliability for succes...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $160K *

Elevate customer solutions by providing architectural expertise and innovative strategies. Collaborate with account teams and partners to deliver high-value technical consulting and drive competitive...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$141K - $224K *

Optimize advanced high-speed communications modem solutions for space and terrestrial applications. Lead system architecture, manage requirements, and provide technical direction across multidisciplin...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$225K - $280K *

Engage as a key technical resource for channel sales, driving success with global partners. Leverage your expertise in networking solutions to enhance relationships, deliver impactful demos, and suppo...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $170K *

Lead the charge in defining and overseeing enterprise automation architecture, ensuring scalable, secure solutions across platforms like ServiceNow and Microsoft. Collaborate cross-functionally to ali...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$165K - $231K *

Transform complex security challenges into innovative solutions for public-sector and commercial clients. Lead technical pre-sales efforts, collaborating with sales teams to deliver tailored architect...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Transform client needs into innovative data center solutions by leveraging your expertise in electrical and mechanical infrastructure. Collaborate with teams to ensure scalable, reliable designs that...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $105K *

Transform global operations by supporting Power Automate workflows, enhancing collaboration with regional teams, and driving continuous improvement in automation processes to optimize efficiency and e...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in automating and scaling network infrastructure across diverse global datacenters, enhancing performance and security while collaborating with engineering teams to implement robust so...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Unlock potential by designing and implementing fiber network solutions, collaborating with sales and engineering teams to ensure customer satisfaction and compliance while managing multiple projects i...

4 weeks ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$125K - $150K *

Empower a robust enterprise network-security infrastructure by leading initiatives in design, operation, and troubleshooting of advanced firewall systems. Collaborate with cross-functional teams to en...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$147K - $190K *

Lead the charge in defining and guiding enterprise architecture across product systems and business applications. Collaborate with cross-functional teams to translate strategy into actionable designs...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $160K *

Join us to lead innovative Oracle Cloud solutions, collaborating with clients to design and deliver cutting-edge technical architectures that address complex business challenges and drive success in a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$174K - $224K *

Empower organizations by shaping data governance strategies that enhance security, compliance, and operational resilience. Collaborate with cross-functional teams to deliver impactful governance solut...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Engineer scalable Azure data solutions, leading architecture and modernization initiatives. Collaborate with teams to define standards and ensure high-performance data integration, governance, and sec...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$266K - $399K *

Elevate your career by providing technical leadership and expertise in cloud, AI, and DevOps. Collaborate with sales teams to deliver innovative solutions, mentor peers, and drive customer success acr...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $180K *

Empower teams by leading the technical vision and delivery standards for ServiceNow. Drive high-quality implementations across engagements while mentoring talent and collaborating with management to e...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$130K - $160K *

Lead the design and development of robust security architecture for cloud infrastructure and CI/CD pipelines. Partner cross-functionally to embed security in the development lifecycle and evaluate eme...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Media

$63K - $129K *

Manage network designs and solutions supporting mission-critical LAN/WAN needs while ensuring compliance and performance standards. Collaborate with teams and vendors, providing technical expertise to...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$94K - $266K *

Empower customer success by designing and implementing AWS Connect solutions, conducting technology assessments, and leading project communications to enhance contact center operations and agent produ...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$145K - $170K *

Design innovative AI solutions on Microsoft Azure, bridging business needs and engineering execution. Own the architecture, ensure security, and lead the build process while adapting to evolving proje...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$132K - $302K *

Join a team that's driving innovation in ServiceNow solutions. As a Technical Architect, you'll lead enterprise transformations, mentor developers, and craft strategic solutions for Fortune 500 client...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$224K - $431K *

Join a team that's redefining AI networking by driving innovation in performance and scalability of distributed systems, optimizing data processing for large language models and generative AI workload...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$181K - $226K *

Join our dynamic team as a Software Engineer, where you'll enhance internal tools, collaborate with stakeholders, and drive improvements in cloud infrastructure and observability, all while working in...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$108K - $130K *

Advance your career by overseeing the reliability and support of network systems. Play a key role in designing and maintaining software automation, ensuring operational stability across platforms and...

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.