Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Manager, Infrastructure Governance
$125K - $178K *
Accelerate progress at the forefront of cloud security governance, leading a dynamic team to enhance compliance, drive automation, and ensure robust risk management across multi-cloud environments...
5 days ago
$135K - $160K *
Transform product security by leading strategy, conducting threat modeling, and collaborating across teams to ensure secure design and compliance. Drive innovation in security practices while mentorin...
3 weeks ago
$135K - $160K *
Elevate security practices by building and managing a comprehensive security program. Collaborate with engineers to identify vulnerabilities, implement automated checks, and ensure robust protection a...
1 week ago
Presales Solutions Specialist - Network
$100K - $150K *
Deliver expert network solutions to empower Commercial sales teams, enhancing mid-market account growth. Collaborate closely with reps to qualify opportunities, scope solutions, and drive successful d...
1 week ago
Machine Learning Engineer (Model Dev)
$140K - $180K *
Transform cancer care by developing AI biomarkers through collaboration with ML scientists and clinical partners, enhancing model robustness and interpretability across diverse datasets to improve pat...
3 weeks ago
$116K - $157K *
Advance engineering excellence by leading multi-disciplinary teams to deliver projects on time and within budget. Collaborate across departments to ensure compliance with specifications while mentorin...
3 days ago
Technical Architect - ML - GenAI
$150K - $180K *
Architect scalable Generative AI solutions using AWS tools, focusing on LLMs, RAG, and agent-based workflows. Collaborate with teams to ensure performance and cost efficiency while guiding implementat...
Reposted 1 week ago
Endpoint Security Engineer III
$101K - $111K *
Design and sustain advanced endpoint security solutions for a major enterprise. Collaborate with vendors and stakeholders to enhance security capabilities, ensuring robust protection across diverse en...
Yesterday
$140K - $184K *
Pioneer the development and operational convergence through automation, designing CI/CD pipelines and driving release process efficiency to enhance software delivery across diverse teams and projects...
Reposted today
$68K - $143K *
Join us to enhance business processes through analysis and reengineering, collaborating with stakeholders to ensure effective solutions and implementation. Drive efficiency and innovation in transport...
1 week ago
$125K - $155K *
Join our dynamic team as a Senior Solutions Engineer, where you'll leverage your technical expertise to drive pre-sales activities, engage with clients, and deliver tailored solutions that enhance bus...
4 weeks ago
$90K - $137K *
Unlock your potential as you drive secure automation for cloud migrations, developing infrastructure as code and CI/CD pipelines. Collaborate with teams to enhance processes and ensure compliance whil...
5 days ago
$80K - $95K *
Join a team that's dedicated to enhancing housing standards through comprehensive inspections and evaluations of federally subsidized properties, ensuring compliance with safety regulations and improv...
3 days ago
BPaaS GTM Solutions Architect (Provider, Hospitals, Clinic)
$182K - $337K *
Create innovative AI-native business process solutions for healthcare providers. Collaborate with stakeholders to design efficient architectures that enhance operations and drive digital transformatio...
2 days ago
Lead Solutions Architect - DERMS
$103K - $154K *
Innovate and lead technical solutions for utility challenges, driving strategic growth through effective pre-sales engagement and deep collaboration with clients and internal teams to deliver tailored...
Reposted 2 weeks ago
$160K - $230K *
Join a team that's redefining product engineering by owning high-impact areas from concept to launch. Collaborate closely with leadership to enhance user experiences and drive innovation in a fast-pac...
Today
Senior Software Engineer | C5 SW Architect
$157K - $174K *
Join a team that's shaping the future of combat vehicle software. Lead architectural design and technical direction for mission-critical systems, integrating advanced technologies in a collaborative...
6 days ago
Senior Project Manager - Data Center
$110K - $130K *
Drive project success by leading high-value construction initiatives from concept to completion. Collaborate with diverse teams, manage budgets, and ensure safety while mentoring staff to deliver inno...
1 week ago
Associate Counsel - Subcontract Operations
$110K - $130K *
Transform procurement operations by providing expert legal counsel on subcontracts and purchase orders. Collaborate with teams to navigate complex claims and ensure compliance in a dynamic, fast-paced...
2 weeks ago
Infrastructure Systems Engineer III
$85K - $111K *
Optimize infrastructure solutions by leading cross-functional teams to design, implement, and support resilient systems. Collaborate with diverse stakeholders to ensure timely delivery and operational...
5 days ago
$110K - $140K *
Join a team that's dedicated to designing and implementing resilient infrastructure solutions that enhance operational readiness and supportability while aligning with enterprise architecture standard...
6 days ago
IP and Technology Transactions Attorney
$170K - $200K *
Drive impactful legal strategies by leveraging your expertise in intellectual property and technology transactions. Join a dynamic team to negotiate contracts and advise on legal matters, contributing...
3 weeks ago
National Account Data Center Segment Mgr, West Job
$90K - $125K *
Drive growth in the Data Center market by leading sales strategies, developing key relationships, and executing innovative initiatives to achieve market leadership in the West region. Shape the future...
4 days ago
Senior Data Center Commissioning Engineer
$130K - $171K *
Lead the charge in building and executing a comprehensive commissioning program for Modular Data Centers, ensuring optimal performance from factory testing to operational handover while collaborating...
4 days ago
$108K - $130K *
Innovate the go-to-market systems by building AI agents and infrastructure that drive pipeline efficiency, ensuring seamless integration and reliability across sales and marketing operations...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.