Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Drive the design and optimization of network infrastructure, ensuring reliability and security. Collaborate with IT teams to develop policies, troubleshoot issues, and maintain compliance with best pr...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $215K *

Unlock potential by leading the transition of a GCP platform to AWS, ensuring compliance with federal security standards. Leverage your AWS expertise to design secure, scalable solutions while mentori...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$130K - $180K *

Lead enterprise IT initiatives by assessing environments, developing solution architectures, and overseeing implementations. Collaborate with stakeholders to ensure alignment with organizational stand...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$150K - $180K *

Engineer cutting-edge blockchain infrastructure for financial markets. Drive architecture, design proofs of concept, and ensure interoperability while collaborating with teams to meet institutional re...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $100K *

Join a team that's redefining telecommunications by providing expert Tier 3 and 4 support, engineering, and deployment for cutting-edge voice solutions. Collaborate with peers and mentor junior member...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Transportation

$120K - $145K *

Join a dynamic team to lead connectivity projects for leased data centers, ensuring compliance with standards and managing cross-functional collaboration from site assessment to operational handoff. D...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$320K - $488K *

Optimize the end-to-end software architecture for high-performance rack-scale solutions, collaborating with teams and customers to ensure product alignment and execution. Drive innovation while mentor...

RemoteRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Join us to lead the delivery of network infrastructure, overseeing contractors and ensuring high-quality installations. You'll manage site execution, coordinate with teams, and drive project success t...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Transform enterprise network architecture by leading LAN migration projects, ensuring seamless transitions to Cisco SDA fabric. Collaborate with cross-functional teams to execute plans, manage changes...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $120K *

Drive excellence in network operations by providing 24/7 support, designing solutions, and ensuring compliance with security best practices. Collaborate with teams to enhance customer connectivity and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Join a team that's redefining network solutions by designing, implementing, and supporting advanced LAN, WAN, and wireless systems. Collaborate with cross-functional leaders to enhance network strateg...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$184K - $356K *

Transform data processing architectures by optimizing performance and efficiency. Collaborate with diverse teams to enhance user experiences and drive innovation in hardware-software co-design for cut...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$156K - $215K *

Empower innovation in advanced networking and enterprise solutions by defining strategic roadmaps and driving product lifecycle planning across high-speed networking, optical technologies, and AI plat...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $132K *

Join a team that's redefining network infrastructure for healthcare solutions. You'll design, implement, and support advanced wired and wireless networks, ensuring seamless connectivity and optimal pe...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$320K - $405K *

Transform the future of data center engineering by resolving on-site technical issues, collaborating with contractors, and ensuring project success through effective problem-solving and communication...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $236K *

Join a team that's redefining solution architecture by designing innovative, scalable systems across diverse technologies. Collaborate with cross-functional teams to ensure alignment with enterprise s...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join us as a senior technology leader to define and govern enterprise architecture, ensuring alignment with strategic business objectives while leveraging AI for enhanced decision-making and execution...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Innovate solutions for network modernization by leading design, testing, and implementation efforts. Collaborate with stakeholders to ensure seamless integration of Ciena products, enhancing performan...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$156K - $240K *

Innovate solutions at the intersection of cloud technology and engineering. Lead AWS projects, mentor teams, and drive best practices while ensuring delivery excellence across multiple client engageme...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$148K - $215K *

Unlock your potential by leading the design and optimization of enterprise load balancing solutions. Collaborate with cross-functional teams to enhance application delivery and ensure high availabilit...

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$147K - $232K *

Join a dynamic team to design, secure, and maintain resilient network architectures. Leverage your expertise in troubleshooting and project management while mentoring engineers to enhance operational...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Unlock potential by leading a multidiscipline team in architectural projects, ensuring code compliance, coordinating workflows, and delivering high-quality documents on schedule while fostering collab...

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Lead the charge in shaping architectural design and integrity of core systems. Collaborate with senior leaders to set technical direction, evaluate new technologies, and resolve complex issues, paving...

1 week ago

  •   8 - 10 years exp.  •   Transportation

$80K - $95K *

Lead integrated design efforts and mentor staff while driving business development and fostering community engagement in a dynamic architectural environment...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $120K *

Optimize integration processes by bridging technical gaps between systems. Collaborate with campus IT to ensure seamless data flows, troubleshoot issues, and enhance integration reliability for succes...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.