Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Systems Engineer (Expert) Job# 934
$130K - $155K *
Lead cross-functional engineering teams to enhance geospatial intelligence solutions, ensuring timely and accurate delivery through expert systems engineering, integration, and strategic planning acro...
5 days ago
$170K - $230K *
Join a team that's redefining SoC design by owning subsystem development, integrating third-party IP, and optimizing PPA for next-gen architectures. Contribute across all design stages and drive impac...
1 week ago
SAP Principal Pre-Sales & Delivery Architect
$150K - $180K *
Join us to lead solution direction across multiple SAP engagements, ensuring customer value and platform adoption. Collaborate with teams to shape proposals, drive delivery, and influence product deve...
Today
$157K - $283K *
Elevate your career by managing complex R&D projects in wireless communication, focusing on 6G security for military applications. Collaborate with multidisciplinary teams to deliver innovative soluti...
6 days ago
$98K - $206K *
Elevate your career by developing and maintaining cloud infrastructure for a critical Department of the Air Force project. Collaborate with experts to enhance security and efficiency in an Azure envir...
2 days ago
Security Operations Engineer II
$84K - $124K *
Drive the evolution of Cyber Defense by engineering and automating security operations, enhancing incident response, and maintaining enterprise security platforms to ensure robust protection and swift...
2 weeks ago
Director, Data Center Solutions Architect
$165K - $228K *
Engage with customers to shape the future of Hyperscale Data Center networks. Lead architecture discussions, drive technology roadmaps, and collaborate with teams to deliver scalable, high-performance...
3 days ago
$170K - $240K *
Lead the charge in shaping data architecture strategies, driving innovation across platforms, and mentoring teams to optimize data governance and AI integration for scalable solutions that deliver mea...
2 weeks ago
$240K - $300K *
Empower strategic partnerships across the Eastern U.S. to drive revenue growth. Build and manage a partner-sourced pipeline, enhance customer engagement, and accelerate deal closures through collabora...
1 week ago
$107K - $145K *
Drive success by managing complex technology construction projects, optimize resources, ensure client satisfaction, and lead teams to achieve high quality and productivity in project completion. Trave...
Reposted 3 weeks ago
Senior Advanced IT Network Site Reliability Engineer
$139K - $151K *
Join a team that's pushing the boundaries of advanced technologies. Lead initiatives in network infrastructure, implementing and troubleshooting solutions that support critical missions across various...
Yesterday
$91K - $161K *
Join a team that's shaping the future of cloud IT by designing secure, scalable systems. Collaborate across the organization to implement innovative solutions and drive operational excellence, leverag...
Reposted today
$110K - $130K *
Join a team that's redefining application security by guiding customers through complex evaluations. Leverage your expertise in offensive security to build relationships, deliver impactful demos, and...
1 week ago
Associate Staff Engineer - INFOR M3 Technical Consultant
$100K - $120K *
Optimize your career as an Infor M3 Technical Consultant, leveraging 3-5 years of expertise in integrations and development. Collaborate with teams to design and support seamless enterprise solutions...
3 weeks ago
Technical Architect – Appian & Salesforce Platforms
$172K - $210K *
Architect and lead customer-focused application development initiatives, translating business needs into robust software solutions. Leverage modern technologies and AI tools to ensure high-quality, se...
2 weeks ago
Principal AI Solutions Architect, Customer Success
$135K - $238K *
Elevate customer experiences by designing and developing cutting-edge AI-driven bot applications. Collaborate with teams to deliver innovative solutions, manage strategic projects, and leverage advanc...
Today
Infrastructure Security Team Lead
$143K - $214K *
Oversee and enhance security measures across network, compliance, and access management. Collaborate with teams to design and implement resilient infrastructure while leading a high-performing securit...
1 week ago
$320K - $488K *
Partner with us to lead developer relations in quantum computing, driving adoption of innovative SDKs. Collaborate across federal programs as a strategic bridge to elevate scientific research and tech...
Reposted 1 week ago
Director, Infrastructure Engineering
$170K - $250K *
Help us build a high-performing infrastructure team that drives operational excellence and reliability. Lead a diverse group of engineers, manage budgets, and modernize technology while collaborating...
3 weeks ago
Senior Solutions Architect, Pre-Sales (Banner or Colleague Exp Required) | Remote
$120K - $145K *
Lead the charge in designing scalable, cloud-based SaaS solutions for Higher Education. Collaborate with cross-functional teams to translate institutional needs into actionable solutions, ensuring ali...
2 weeks ago
Electrical Engineer II - Building Services
$80K - $95K *
Join a team that's dedicated to developing detailed electrical designs for diverse industrial and commercial projects. Collaborate with engineers and vendors to ensure compliance with codes and standa...
2 weeks ago
Director of Client Development - Design-Build & EPC Capital Projects (Semiconductor)
$150K - $180K *
Partner with us to drive innovative solutions in architecture, engineering, and construction. You'll collaborate across disciplines, leveraging your expertise to optimize project delivery and exceed c...
Reposted 1 week ago
Program Manager, Data Center and AI
$117K - $147K *
Empower multi-site data center and AI infrastructure programs valued at $25M+, leading diverse teams to ensure successful delivery, budget management, and customer satisfaction while driving executive...
6 days ago
$250K - $500K+*
Optimize and innovate software kernels for hardware integration, collaborating with ML Research and Hardware Engineering teams to enhance performance and efficiency in cutting-edge technology applicat...
5 days ago
Enterprise Architect for Finance & Corp Functions
$139K - $232K *
Unlock potential by providing enterprise architecture leadership for Corporate Functions, focusing on Finance and supporting areas. Shape technology strategies and roadmaps to enhance financial manage...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.