Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Network Architect Jobs in Missouri

Sort By: Relevance

$138K - $184K *

Lead the charge in designing resilient electrical systems for mission-critical facilities. Collaborate with teams to oversee full-cycle electrical design, ensuring high availability and operational ex...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$113K - $142K *

Engineer innovative electrical designs for modular data centers, ensuring compliance and performance across international standards. Collaborate with teams to deliver hands-on solutions from concept t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$198K - $258K *

Lead the charge in defining and governing architectural strategies for a secure and scalable software ecosystem across device and digital platforms, influencing cross-functional teams and senior stake...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

$63K - $111K *

Empower mission success by assessing utility vulnerabilities and enhancing infrastructure resilience against diverse threats. Collaborate with a multidisciplinary team to ensure operational continuity...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform vulnerability detection by leveraging innovative technology and research. Join a team dedicated to crafting detection logic to identify critical vulnerabilities, ensuring clients stay one st...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$102K - $209K *

Transform data center operations by leading end-to-end capacity delivery programs. Collaborate with diverse teams to ensure timely project execution, quality assurance, and stakeholder engagement, dri...

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Lead the architectural direction of order-to-cash solutions across multiple customer engagements, ensuring effective design, integration, and adoption of SAP systems while leveraging AI tools for enha...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Join a dynamic team to enhance application security across web apps, APIs, and cloud services. Collaborate with development squads to prioritize vulnerabilities and implement proactive remediation str...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Transform application security practices by enhancing web, API, and cloud service protections. Collaborate with development teams to remediate vulnerabilities and integrate security into CI/CD workflo...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$153K - $166K *

Join a team that's shaping the future of AI governance in software development. As a Senior Engineer, you'll design policies and tools that ensure safe, effective use of AI coding agents, empowering d...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$180K - $200K *

Engage in the design-build process, coordinating teams and managing risks to ensure projects are ready for construction. Oversee design accuracy, cost efficiency, and effective handoffs to project man...

2 weeks ago

  •   8 - 10 years exp.  •   Staffing

$150K - $180K *

Join a team that's shaping the future of AI by designing and implementing enterprise-grade solutions on Google Cloud and Azure, focusing on data migration, pipeline development, and robust cloud infra...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$163K - $214K *

Lead the charge in defining strategic market presence and network design. Drive investment decisions by analyzing demand, competition, and demographics to optimize facility configurations across multi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$150K - $180K *

Advance offensive security research by designing red team agents and automating tradecraft. Shape full-chain operations across diverse environments, ensuring robust detection-evasion capabilities and...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Technical Services

$122K *

Transform enterprise Windows infrastructure and cloud environments by designing, implementing, and securing systems. Collaborate with IT teams to optimize performance, automate processes, and ensure c...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Join a team that's committed to operational excellence, overseeing technical operations and maintenance for a federal courthouse. Lead a skilled team to ensure safety, reliability, and compliance whil...

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$79K - $103K *

Join a team dedicated to overseeing the full lifecycle of government and commercial contracts. You'll manage negotiations, ensure compliance, and provide strategic guidance while fostering effective p...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Drive the future of engineering workflows by building and delivering robust AI-driven automation and agent-based capabilities, ensuring products meet real customer needs and are reliable for complex e...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$84K - $111K *

Elevate project success by managing diverse construction projects from start to finish. Ensure quality, maintain schedules, and engage with clients, contractors, and teams while adapting to evolving p...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$103K - $181K *

Unlock your potential by leading innovative rail transit projects, managing complex CBTC systems, and ensuring compliance with industry standards while fostering a culture of continuous improvement an...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Join a team that's shaping the future of DevSecOps by guiding customers in building robust processes. Collaborate across departments to deliver tailored solutions and showcase the value of innovative...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$152K - $175K *

Champion the security of GPU cloud infrastructure by architecting solutions that ensure robust tenant isolation, securing systems from vulnerabilities, and implementing innovative code at the OS level...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$87K - $253K *

Unlock potential by architecting enterprise data fabric solutions that enable unified, intelligent access to distributed data across on-prem and multi-cloud environments, driving analytics and AI thro...

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$125K - $144K *

Optimize our data platform by owning end-to-end data engineering projects, leveraging AI coding agents, and ensuring data quality. Collaborate with cross-functional teams to deliver reliable, maintain...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$102K - $190K *

Lead the charge in managing firewall infrastructure engineering, ensuring operational excellence, scalability, and security. Drive team performance, oversee lifecycle management, and enhance capabilit...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.