Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Enterprise Cloud Data Architect
$188K - $226K *
Lead the charge in defining and governing a next-gen enterprise data ecosystem, focusing on cloud data strategy, architecture, and AI readiness to ensure secure, scalable, and high-quality data aligne...
3 weeks ago
$86K - $138K *
Pioneer cloud engineering solutions by optimizing performance and reliability. Collaborate with teams to design and implement cloud technologies, ensuring six sigma standards and continuous improvemen...
2 weeks ago
$95K - $100K *
Optimize enterprise secrets management by implementing and maintaining solutions across multi-cloud environments. Collaborate with teams to integrate security processes, enhance governance, and suppor...
Today
Program Manager (Data Center Hardware)
$145K - $155K *
Transform customer engagements by leading a dynamic team, ensuring project success through effective management and operational oversight. Drive continuous improvement and enhance client satisfaction...
Today
SAP Senior Solution Architect, Manufacturing
$150K - $232K *
Lead transformative SAP solutions in manufacturing, optimizing processes and driving innovation. Collaborate with teams to deliver value-driven results, leveraging deep expertise in SAP S/4HANA and bu...
1 week ago
Network and Systems Engineer III – IT Solutions Implementor
$110K - $132K *
Innovate IT solutions by evaluating project requirements, providing technical support, and maintaining network infrastructure. Collaborate with teams globally to ensure seamless operations and enhance...
Yesterday
Technical Enablement Manager, Identity Security
$130K - $160K *
Join a team that's shaping the future of identity security by developing impactful enablement programs for pre-sales teams. Collaborate with cross-functional leaders to enhance skills and drive busine...
3 weeks ago
Staff AI Engineer, Agentic Automation
$150K - $180K *
Help us drive the future of automation by owning AI agents that onboard applications and ensure self-healing workflows. You'll enhance existing systems, prioritize security, and collaborate across tea...
6 days ago
Director, Analytics & Semantic Layer
$130K - $160K *
Drive the development of a semantic layer for a data and AI organization, defining key metrics and leading an analytics engineering team. Build core models and ensure definitional consistency across v...
2 weeks ago
Acoustics Engineer, Capacity Delivery
$100K - $120K *
Innovate noise control solutions for large-scale AI data centers. Lead acoustic studies, model sound propagation, and recommend effective mitigations while collaborating across engineering teams to en...
Reposted today
$125K - $150K *
Design and implement a robust cybersecurity strategy, leading a team to secure infrastructure and data. Collaborate with stakeholders to enhance security measures, manage vendor relationships, and ens...
2 weeks ago
$150K - $180K *
Lead the charge in enhancing engineering security for our SaaS platform. Collaborate with teams to identify risks, improve practices, and implement automation, ensuring secure development and robust v...
5 days ago
Senior Computer Systems Engineer/Architect - Informatica
$170K - $210K *
Lead the design and implementation of cross-platform solutions in AWS GovCloud, focusing on Informatica architecture, security, and CI/CD practices. Collaborate with multidisciplinary teams to ensure...
1 week ago
$218K - $256K *
Lead the charge in shaping IT strategy and operations for a remote-first SaaS company. Drive service delivery, enhance employee technology experiences, and build a high-performing IT organization whil...
2 weeks ago
$90K - $110K *
Lead the charge in delivering innovative managed services solutions by partnering with sales teams to assess client needs, design scalable architectures, and ensure seamless transitions, driving long...
5 days ago
$88K - $105K *
Elevate project outcomes by overseeing construction initiatives from inception to completion, ensuring compliance, managing budgets, and fostering collaboration among stakeholders to deliver quality r...
4 weeks ago
Technical Solutions Consultant - Americas
$100K - $120K *
Inspire customer success by bridging technical expertise with client-facing roles. Guide complex product implementations and integrations, ensuring high-quality support and solutions tailored to diver...
Reposted 3 weeks ago
$150K - $180K *
Champion enterprise systems diligence and value creation engagements, assessing technology, processes, and infrastructure to drive operational excellence and strategic insights for investors and manag...
2 weeks ago
Lead Director - Network Core Infrastructure Operations
$144K - $288K *
Engage in a pivotal leadership role overseeing core network infrastructure operations. Drive stability, performance, and security across WAN and LAN environments while mentoring a skilled team and man...
Reposted 1 week ago
Principal Data Architect Job Details | curium
$130K - $155K *
Lead the design and governance of enterprise data architecture to enhance business intelligence, analytics, and digital transformation. Collaborate with stakeholders to ensure data alignment with stra...
2 weeks ago
Deployment Engineer (Tuesday-Saturday workweek)
$80K - $95K *
Explore a key role in our team as you manage and optimize software deployments, ensuring seamless integration and functionality of critical financial applications for our clients while collaborating w...
Reposted 2 weeks ago
Staff Security Engineer - Calix Cloud
$136K - $265K *
Unlock potential by designing and securing advanced trust architectures across devices and cloud platforms. Collaborate with engineering teams to enhance security measures, conduct threat modeling, an...
Today
Architect - Platform Engineering - USA
$150K - $180K *
Join a dynamic team to architect and implement cutting-edge MLOps strategies, leveraging Google Cloud's AI/ML stack. Drive innovation in model lifecycle management and collaborate with cross-functiona...
1 week ago
Enterprise Cybersecurity Manager
$101K - $158K *
Lead enterprise-wide cybersecurity initiatives, aligning operations and compliance with strategic goals. Drive actionable security plans, manage risks, and enhance capabilities while fostering a high...
1 week ago
$98K - $206K *
Drive innovation as a Senior Endpoint Engineer, collaborating with a skilled team to enhance endpoint management and automation, ensuring efficient deployments and robust security for critical systems...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.