Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$175K - $195K *
Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...
5 days ago
Software Architect (AWS/Azure)
$101K - $135K *
Join a team that's shaping the future of healthcare technology by designing and enhancing our build and delivery infrastructure. Collaborate with architects and developers to implement best practices...
1 week ago
Principal Architect - Data Centers
$125K - $200K *
Join a team that's redefining architectural excellence by leading global projects, driving business growth, and fostering client relationships while overseeing studio operations and strategic initiati...
Yesterday
Technical Architect Contractor
$110K - $130K *
Unlock potential by leveraging your Salesforce expertise to design, build, and review secure, scalable solutions. Collaborate with clients and teams to ensure seamless integrations and effective deliv...
1 week ago
Computer Systems Engineer/ Architect
$110K - $130K *
Unlock potential by designing and optimizing enterprise data solutions in a Databricks Lakehouse environment, supporting critical missions with a focus on scalability and best practices...
Reposted 2 weeks ago
Enterprise Integration Architect
$135K - $160K *
Transform enterprise integration strategies into actionable architectures, ensuring secure, scalable connectivity across applications and data platforms. Collaborate with cross-functional teams to est...
3 weeks ago
$120K - $145K *
Champion innovative solutions by collaborating with clients to align IT capabilities with business goals. Leverage your expertise in enterprise architecture to drive strategic initiatives and optimize...
2 weeks ago
$160K - $200K *
Transform security architecture by defining standards, leading reviews, and managing risks. Collaborate with teams to ensure secure, efficient integration of applications and AI, while maintaining cle...
1 week ago
Principal Software Architect - Emerging Technologies
$175K - $222K *
Engage in architecting high-volume autonomous agent pipelines, ensuring safety, performance, and compliance. Own the generator-verifier architecture and CI/CD processes while setting engineering stand...
5 days ago
Security & Infrastructure Architect
$104K - $156K *
Drive security architecture across AWS and Azure, ensuring secure configurations and compliance. Collaborate with teams to implement standards, review designs, and maintain documentation as the cloud...
Yesterday
$80K - $96K *
Innovate systems design and implementation, ensuring optimal performance and client satisfaction through technical support, programming, and commissioning of integrated security and audio-visual syste...
5 days ago
$66K - $106K *
Contribute to data-driven decision-making by designing and optimizing analytic solutions. Leverage your expertise in SQL and Tableau to transform raw data into actionable insights for mission-critical...
1 week ago
$105K - $160K *
Empower channel partners by providing technical leadership and solution architecture expertise focused on HPE Aruba technologies. Drive sales engagement and architect resilient infrastructure solution...
5 days ago
$112K - $179K *
Join a team that's shaping enterprise security architectures to protect vital information systems. You'll design, govern, and implement security solutions across diverse environments, ensuring complia...
5 days ago
$154K - $232K *
Transform enterprise cloud strategies by leading large-scale migrations to Azure and AWS. Collaborate with global teams to establish architecture standards, ensure security, and drive innovative solut...
4 days ago
$130K - $155K *
Lead the charge in architecting innovative End User Computing solutions, collaborating with account teams and clients to drive strategy, deliver presentations, and enhance customer experiences while e...
2 weeks ago
$110K - $130K *
Lead the charge in designing innovative technology solutions that empower product engineering teams, ensuring alignment with enterprise standards and modern practices in a regulated financial services...
2 weeks ago
$110K - $130K *
Shape the future of technology solutions by providing technical leadership and guidance to product engineering teams, ensuring alignment with architectural principles and promoting best practices in a...
3 weeks ago
$150K - $180K *
Join a team that's redefining construction technology by architecting scalable, reliable systems that integrate cutting-edge AI and computer vision. Collaborate across disciplines to drive innovation...
2 weeks ago
$122K - $261K *
Elevate employee experiences by leading digital transformation initiatives, providing strategic guidance, and implementing scalable solutions across enterprise environments to enhance productivity and...
1 week ago
$150K - $250K *
Accelerate progress at the forefront of AI technology by building and operating a secure, production-grade platform. Collaborate with business teams to transform AI capabilities into measurable value...
Reposted 6 days ago
$95K - $115K *
Lead the development and implementation of technical solutions for clients, ensuring project success through collaboration and effective communication. Drive innovation while maintaining high standard...
1 week ago
Technical Solutions Architect - Anthropic / Claude Cowork
$165K - $185K *
Lead the charge in transforming organizations through AI adoption. Collaborate with cross-functional teams to design and implement innovative solutions that enhance productivity and drive measurable o...
2 weeks ago
$130K - $140K *
Lead the charge in designing and implementing advanced network security solutions, focusing on Zero Trust principles and SD-WAN architecture. Collaborate with cross-functional teams to enhance network...
3 weeks ago
Principal Architect, Healthcare
$165K - $243K *
Deliver innovative disaster recovery solutions for healthcare systems, ensuring compliance and resilience for clinical workloads. Collaborate with cross-functional teams to address complex challenges...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.