Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$150K - $180K *

Unlock the potential of Oracle solutions by leading multi-engagement pre-sales and delivery efforts. Drive customer adoption and value through strategic solution design, ensuring seamless integration...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$108K - $181K *

Partner with us to drive growth in the data center market by building strategic relationships with hyperscalers and colocation providers, shaping innovative solutions, and leading negotiations to secu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Elevate security standards by leading bug bounty programs, conducting audits, and enhancing software supply chain security. Collaborate across teams to build innovative tools that protect users and en...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$128K - $225K *

Unlock potential by leading cloud engineering strategy and product development. Oversee a high-performing team to deliver secure, scalable cloud solutions across multiple providers, ensuring alignment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $180K *

Join us to lead our accounting operations, ensuring accuracy and scalability. Drive financial reporting, audits, and team development while applying your technical expertise in a dynamic, multi-channe...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Transform business workflows by developing and maintaining applications that enhance productivity and information sharing across teams. Collaborate with IT and business units to deliver innovative sol...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Technical Services

$90K - $110K *

Join a dynamic team as you drive growth by designing tailored software solutions for schools. Leverage your technical expertise to engage clients, deliver impactful demos, and collaborate with cross-f...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$119K - $179K *

Support the integration and harmonization of clinical data by designing FHIR-compliant models and pipelines, ensuring data accuracy and usability for patient care and research initiatives across the o...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Drive enterprise IT infrastructure and security initiatives, optimizing cloud and networking environments while mentoring support staff and leading technology upgrades to enhance organizational perfor...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K *

Join a team that's dedicated to driving sales success through lead generation and client education. This role involves delivering impactful product demonstrations and collaborating with sales teams to...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$145K - $175K *

Advance your career by overseeing Oracle system integrations across multiple customer engagements. Collaborate with teams to enhance platform ownership and provide pre-sales support, ensuring seamless...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in cloud security engineering by managing a team of experts to design and implement robust security controls across AWS, Azure, and GCP, ensuring compliance and operational excellence...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $185K *

Join us to lead a dynamic team of DevOps, MLOps, and DataOps engineers, driving innovation across our multi-cloud platform. You'll mentor talent, set technical standards, and remain hands-on in engine...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $189K *

Engineer innovative electrical designs, ensuring compliance and safety for mission-critical power and cooling products. Collaborate cross-functionally to integrate systems, manage changes, and execute...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$90K - $125K *

Join a team that's dedicated to building robust software solutions. Collaborate with cross-functional teams to design, develop, and maintain high-quality applications while ensuring reliability and pe...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$68K - $99K *

Unlock potential by driving sales of Hybrid Infrastructure services, expanding market presence, and managing the full sales lifecycle. Build relationships, identify opportunities, and collaborate with...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$160K - $180K *

Lead a high-performing team of Solutions Architects to drive strategic market expansion and enhance presales execution. Collaborate across functions to ensure alignment and deliver impactful solutions...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Drive the architecture and delivery of AI-ready Microsoft 365 solutions, overseeing end-to-end engagements for mid-market and enterprise clients. Lead design, deployment, and adoption while ensuring s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $197K *

Transform geospatial solutions by architecting and integrating enterprise ArcGIS systems for Defense and Intelligence operations, ensuring secure, scalable architectures that enhance decision-making a...

Today

  •   8 - 10 years exp.  •   Information Technology

$111K - $186K *

Optimize security architecture for cloud and on-premise systems. Collaborate with teams to ensure secure designs, conduct risk assessments, and develop reusable guidance. Leverage your cybersecurity e...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$171K - $190K *

Unlock potential by leading the design and implementation of scalable data platforms. Drive innovation in cloud data architecture and pipeline automation, collaborating across teams to deliver impactf...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Transform customer engagements by owning solution direction across multiple accounts. Drive platform adoption, orchestrate delivery teams, and shape opportunities to ensure measurable value and long-t...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$135K - $160K *

Empower your career by leading the charge in Kubernetes innovation. As a Cloud Native Architect, you'll leverage your expertise to transform customer experiences and drive the adoption of stateful app...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$95K - $125K *

Join a team that's transforming HR and payroll solutions by engaging clients, conducting tailored demos, and bridging business needs with technical expertise to enhance workforce management and compli...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Transform the future of power management by architecting data solutions that integrate telemetry, financials, and operational insights into a cohesive digital twin, enhancing decision-making across th...

3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.