Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$122K - $150K *

Support the design and maintenance of a global virtual desktop environment, serving as the SME for troubleshooting and optimizing performance while collaborating across multiple complex production env...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $197K *

Drive innovation by architecting enterprise-scale ArcGIS solutions, designing secure deployment architectures, and guiding modernization strategies. Collaborate with clients to develop technology road...

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$150K - $200K *

Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$103K - $134K *

Drive business growth by leading strategic partnerships and customer engagement. Collaborate across teams to achieve sales targets, enhance market presence, and foster strong client relationships whil...

6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$104K - $130K *

Contribute to ICT design and project management for mission-critical data centers and smart buildings. Collaborate with technical teams, manage project scopes, and utilize advanced tools to enhance ef...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$150K - $210K *

Transform Oracle Cloud ERP solutions by leading technical architecture and ensuring quality. Collaborate with teams to drive design decisions and deliver successful implementations while mentoring oth...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $110K *

Unlock potential by leading enterprise network transformations with SASE and SD-WAN solutions. Mentor engineers, manage complex projects, and deliver exceptional managed services while ensuring client...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$206K - $267K *

Optimize technology investments by providing visionary architecture leadership, aligning enterprise capabilities with corporate goals, and driving strategic initiatives to enhance operational efficien...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Transportation

$80K - $95K *

Optimize IT operations by managing day-to-day support for macOS and Windows environments, ensuring seamless onboarding/offboarding, and administering SaaS platforms while enhancing user experience and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Champion the creation of semantic models on our Snowflake platform, ensuring accuracy and clarity in financial reporting. Collaborate across teams to translate complex business logic into reliable dat...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$164K - $246K *

Collaborate with cross-functional teams to translate cloud requirements into actionable product strategies, ensuring technical excellence and successful implementations in complex environments...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Join our team to enhance the operational health of AI provider endpoints. You'll ensure fast, reliable routing and proactive problem detection, contributing to a seamless experience for our customers...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$114K - $252K *

Transform the enterprise AI landscape by architecting innovative cloud solutions, enabling optimized workflows across government services, and driving team excellence in AI development and integration...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$144K - $195K *

Innovate and lead the design of identity management solutions, ensuring security and integration across platforms. Collaborate with teams to enhance user experience and manage critical issues in a dyn...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$170K - $187K *

Join a team that's shaping the future of Enterprise Architecture by driving innovative solutions and strategic design for hybrid banking systems. Collaborate across diverse teams to create scalable, f...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$93K - $125K *

Join a dynamic team as a technical resource, enhancing enterprise applications and infrastructure services. Drive operational excellence, support cross-functional initiatives, and ensure reliable, sec...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$166K - $200K *

Lead impactful solutions as a Global Solution Architect, driving business value through strategic customer engagement and technical expertise. Collaborate with sales teams to architect innovative auto...

RemoteRemote

1 week ago

  •   15+ years exp.  •   Manufacturing & Automotive

$135K - $160K *

Champion innovative Salesforce Field Service solutions, leading implementations and integrations while mentoring teams and advising clients on optimization and transformation strategies for enhanced o...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Engage in designing and implementing robust cybersecurity solutions while managing security technologies and cloud services. Collaborate across teams to ensure operational performance and support clie...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$93K - $129K *

Shape your career as an Electrical Engineer by developing permit drawings for diverse projects. Collaborate with teams to provide quality designs, ensuring compliance and efficiency while engaging in...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Shape the future of electrical engineering by collaborating with design teams, ensuring technical compliance, and enhancing performance across diverse projects. Join us to tackle innovative challenges...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$112K - $127K *

Elevate your career by supporting the design and maintenance of enterprise WAN infrastructure. Collaborate with diverse teams to ensure network reliability and performance across multiple locations, e...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Elevate your career by designing and delivering innovative video solutions across diverse sectors. Collaborate with teams to create scalable architectures that enhance broadcast, streaming, and cloud...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$124K - $187K *

Join a dynamic team to define and guide technical direction across platforms, ensuring scalable, secure solutions that align with business outcomes. Collaborate with cross-functional teams to resolve...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Drive impactful solutions by maintaining and developing Finance and Procurement systems. Collaborate with teams to analyze requirements, debug SQL queries, and enhance application performance for a se...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.