Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Microsoft Frontier Solutions Architect
$140K - $175K *
Champion AI innovation by engaging with clients to identify and prototype high-value use cases. Blend technical expertise with advisory skills to drive AI solutions, enhancing productivity and transfo...
2 weeks ago
$145K - $175K *
Deliver innovative datacenter, cloud, and network solutions by leading architecture design, client engagement, and technical governance. Collaborate with cross-functional teams to shape complex infras...
1 week ago
$88K - $105K *
Unlock potential by joining a dynamic team focused on developing innovative software solutions. Collaborate across departments to enhance processes and deliver impactful results for internal teams and...
5 days ago
$110K - $130K *
Innovate secure network solutions by engineering and supporting robust infrastructure. Collaborate with cross-functional teams to enhance security technologies, ensuring reliable connectivity and comp...
2 weeks ago
$180K - $202K *
Drive customer success by serving as a technical expert, guiding implementations and optimizing strategies for Harness AppSec solutions. Collaborate with clients to ensure they achieve maximum value a...
2 weeks ago
Senior Manager, Network Operations
$115K - $125K *
Champion operational excellence by managing cross-regional teams, ensuring consistent performance standards, and facilitating effective agent execution. Drive strategic initiatives and resolve conflic...
1 week ago
Solutions Architect - Pre-Sales (FedD154)
$120K - $145K *
Empower our defense solutions by acting as a trusted technical advisor, engaging with customers to understand their needs, and delivering compelling product demonstrations that showcase our technology...
2 weeks ago
$83K - $124K *
Unlock potential by leading the design and implementation of CI/CD pipelines, enhancing software delivery and operational stability for enterprise applications while collaborating with cross-functiona...
1 week ago
$100K - $129K *
Drive your career with a Senior Network Administrator role, managing and optimizing enterprise network infrastructure. Collaborate across teams to ensure security, performance, and scalability while l...
Today
$135K - $145K *
Deliver seamless integration and Tier 3 support for secure mobile infrastructure. Collaborate with enterprise stakeholders to ensure compliance, performance, and customer satisfaction while managing c...
Reposted 5 days ago
$110K - $120K *
Unlock your potential as a Solutions Engineer, guiding sales teams with expert network security advice, conducting training sessions, and supporting customer needs while driving professional services...
Reposted 2 weeks ago
$143K - $153K *
Empower business transformation by translating capabilities into architectural solutions. Guide design strategies and integration mechanisms while advancing information management and governance acros...
6 days ago
Software Engineer, Developer Products
$120K - $145K *
Join our team to shape external developer experiences through impactful APIs and SDKs. You'll evolve documentation and tools while collaborating across teams to enhance our growing platform and delive...
Reposted today
Chief Architect, Product Engineering
$160K - $200K *
Elevate the technical architecture vision and execution across a product portfolio, driving the transition to a scalable, cloud-native SaaS environment while integrating AI, data, and security. Collab...
4 weeks ago
$119K - $175K *
Drive complex security initiatives, mentor engineers, and lead investigations into high-impact incidents, focusing on AI/LLM security posture and compliance across multiple domains...
4 weeks ago
$135K - $160K *
Join a team that's redefining data architecture by leading innovative modeling and integration initiatives. Collaborate with AI Engineers to create scalable datasets and optimize performance in a mult...
2 weeks ago
$150K - $180K *
Transform enterprise AI solutions by designing and implementing Multi-Agentic AI architectures. Leverage expertise in Generative AI, cloud technologies, and governance to lead projects from proof of c...
2 weeks ago
$87K - $135K *
Drive your career forward by leading systems engineering for a cloud-based enterprise system. Engage in architecture development, integration, and modernization efforts while ensuring security and ope...
2 weeks ago
Oracle OTM Solutions Architect
$125K - $140K *
Join a team that's dedicated to transforming supply chain solutions through innovative Oracle OTM and GTM implementations, ensuring timely delivery and optimal client satisfaction while enhancing your...
Reposted today
Security Engineer, Infrastructure Security
$120K - $145K *
Join us to enhance the security posture of our production platform. As an Infrastructure Security Engineer, you'll drive remediation efforts, build security frameworks, and collaborate with teams to p...
1 week ago
Salesforce Technical Architect
$135K - $160K *
Lead the design and implementation of complex Salesforce solutions in a multi-org federal environment. Drive modernization efforts and ensure compliance while providing technical leadership and mentor...
1 week ago
Principal Technologist - AI Compute
$160K - $200K *
Elevate your career as a Principal Technologist, leading AI compute infrastructure solutions in pre-sales. Collaborate with top-tier clients, drive innovative designs, and influence strategic engageme...
1 week ago
$122K - $150K *
Support the design and maintenance of a global virtual desktop environment, serving as the SME for troubleshooting and optimizing performance while collaborating across multiple complex production env...
1 week ago
Solution Architect - ArcGIS Enterprise | TS/SCI
$120K - $197K *
Drive innovation by architecting enterprise-scale ArcGIS solutions, designing secure deployment architectures, and guiding modernization strategies. Collaborate with clients to develop technology road...
Reposted today
$150K - $200K *
Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.