Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$140K - $175K *

Champion AI innovation by engaging with clients to identify and prototype high-value use cases. Blend technical expertise with advisory skills to drive AI solutions, enhancing productivity and transfo...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $175K *

Deliver innovative datacenter, cloud, and network solutions by leading architecture design, client engagement, and technical governance. Collaborate with cross-functional teams to shape complex infras...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$88K - $105K *

Unlock potential by joining a dynamic team focused on developing innovative software solutions. Collaborate across departments to enhance processes and deliver impactful results for internal teams and...

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Innovate secure network solutions by engineering and supporting robust infrastructure. Collaborate with cross-functional teams to enhance security technologies, ensuring reliable connectivity and comp...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $202K *

Drive customer success by serving as a technical expert, guiding implementations and optimizing strategies for Harness AppSec solutions. Collaborate with clients to ensure they achieve maximum value a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $125K *

Champion operational excellence by managing cross-regional teams, ensuring consistent performance standards, and facilitating effective agent execution. Drive strategic initiatives and resolve conflic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $145K *

Empower our defense solutions by acting as a trusted technical advisor, engaging with customers to understand their needs, and delivering compelling product demonstrations that showcase our technology...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$83K - $124K *

Unlock potential by leading the design and implementation of CI/CD pipelines, enhancing software delivery and operational stability for enterprise applications while collaborating with cross-functiona...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $129K *

Drive your career with a Senior Network Administrator role, managing and optimizing enterprise network infrastructure. Collaborate across teams to ensure security, performance, and scalability while l...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Transportation

$135K - $145K *

Deliver seamless integration and Tier 3 support for secure mobile infrastructure. Collaborate with enterprise stakeholders to ensure compliance, performance, and customer satisfaction while managing c...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $120K *

Unlock your potential as a Solutions Engineer, guiding sales teams with expert network security advice, conducting training sessions, and supporting customer needs while driving professional services...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$143K - $153K *

Empower business transformation by translating capabilities into architectural solutions. Guide design strategies and integration mechanisms while advancing information management and governance acros...

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Join our team to shape external developer experiences through impactful APIs and SDKs. You'll evolve documentation and tools while collaborating across teams to enhance our growing platform and delive...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Elevate the technical architecture vision and execution across a product portfolio, driving the transition to a scalable, cloud-native SaaS environment while integrating AI, data, and security. Collab...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Business Services

$119K - $175K *

Drive complex security initiatives, mentor engineers, and lead investigations into high-impact incidents, focusing on AI/LLM security posture and compliance across multiple domains...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Join a team that's redefining data architecture by leading innovative modeling and integration initiatives. Collaborate with AI Engineers to create scalable datasets and optimize performance in a mult...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Transform enterprise AI solutions by designing and implementing Multi-Agentic AI architectures. Leverage expertise in Generative AI, cloud technologies, and governance to lead projects from proof of c...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$87K - $135K *

Drive your career forward by leading systems engineering for a cloud-based enterprise system. Engage in architecture development, integration, and modernization efforts while ensuring security and ope...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $140K *

Join a team that's dedicated to transforming supply chain solutions through innovative Oracle OTM and GTM implementations, ensuring timely delivery and optimal client satisfaction while enhancing your...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Transportation

$120K - $145K *

Join us to enhance the security posture of our production platform. As an Infrastructure Security Engineer, you'll drive remediation efforts, build security frameworks, and collaborate with teams to p...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Lead the design and implementation of complex Salesforce solutions in a multi-org federal environment. Drive modernization efforts and ensure compliance while providing technical leadership and mentor...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$160K - $200K *

Elevate your career as a Principal Technologist, leading AI compute infrastructure solutions in pre-sales. Collaborate with top-tier clients, drive innovative designs, and influence strategic engageme...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$122K - $150K *

Support the design and maintenance of a global virtual desktop environment, serving as the SME for troubleshooting and optimizing performance while collaborating across multiple complex production env...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $197K *

Drive innovation by architecting enterprise-scale ArcGIS solutions, designing secure deployment architectures, and guiding modernization strategies. Collaborate with clients to develop technology road...

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$150K - $200K *

Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.