Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$120K - $145K *

Join our team to shape external developer experiences through impactful APIs and SDKs. You'll evolve documentation and tools while collaborating across teams to enhance our growing platform and delive...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Champion the security of our AI supercomputer infrastructure, ensuring robust controls and isolation for customer workloads. Collaborate with cross-functional teams to design, implement, and maintain...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Elevate the technical architecture vision and execution across a product portfolio, driving the transition to a scalable, cloud-native SaaS environment while integrating AI, data, and security. Collab...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Business Services

$135K - $160K *

Join a team that's redefining data architecture by leading innovative modeling and integration initiatives. Collaborate with AI Engineers to create scalable datasets and optimize performance in a mult...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Transform enterprise AI solutions by designing and implementing Multi-Agentic AI architectures. Leverage expertise in Generative AI, cloud technologies, and governance to lead projects from proof of c...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$87K - $135K *

Drive your career forward by leading systems engineering for a cloud-based enterprise system. Engage in architecture development, integration, and modernization efforts while ensuring security and ope...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $140K *

Join a team that's dedicated to transforming supply chain solutions through innovative Oracle OTM and GTM implementations, ensuring timely delivery and optimal client satisfaction while enhancing your...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Transportation

$120K - $145K *

Join us to enhance the security posture of our production platform. As an Infrastructure Security Engineer, you'll drive remediation efforts, build security frameworks, and collaborate with teams to p...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Lead the design and implementation of complex Salesforce solutions in a multi-org federal environment. Drive modernization efforts and ensure compliance while providing technical leadership and mentor...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$160K - $200K *

Elevate your career as a Principal Technologist, leading AI compute infrastructure solutions in pre-sales. Collaborate with top-tier clients, drive innovative designs, and influence strategic engageme...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$150K - $200K *

Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$104K - $130K *

Contribute to ICT design and project management for mission-critical data centers and smart buildings. Collaborate with technical teams, manage project scopes, and utilize advanced tools to enhance ef...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$98K - $184K *

Empower your career by joining a dynamic team of Systems Engineers focused on innovative launcher hardware development for Navy platforms. Contribute to system integration, requirements management, an...

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$150K - $210K *

Transform Oracle Cloud ERP solutions by leading technical architecture and ensuring quality. Collaborate with teams to drive design decisions and deliver successful implementations while mentoring oth...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $110K *

Unlock potential by leading enterprise network transformations with SASE and SD-WAN solutions. Mentor engineers, manage complex projects, and deliver exceptional managed services while ensuring client...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$206K - $267K *

Optimize technology investments by providing visionary architecture leadership, aligning enterprise capabilities with corporate goals, and driving strategic initiatives to enhance operational efficien...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Transportation

$80K - $95K *

Optimize IT operations by managing day-to-day support for macOS and Windows environments, ensuring seamless onboarding/offboarding, and administering SaaS platforms while enhancing user experience and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$164K - $246K *

Collaborate with cross-functional teams to translate cloud requirements into actionable product strategies, ensuring technical excellence and successful implementations in complex environments...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Join our team to enhance the operational health of AI provider endpoints. You'll ensure fast, reliable routing and proactive problem detection, contributing to a seamless experience for our customers...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$114K - $252K *

Transform the enterprise AI landscape by architecting innovative cloud solutions, enabling optimized workflows across government services, and driving team excellence in AI development and integration...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$144K - $195K *

Innovate and lead the design of identity management solutions, ensuring security and integration across platforms. Collaborate with teams to enhance user experience and manage critical issues in a dyn...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$170K - $187K *

Join a team that's shaping the future of Enterprise Architecture by driving innovative solutions and strategic design for hybrid banking systems. Collaborate across diverse teams to create scalable, f...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$93K - $125K *

Join a dynamic team as a technical resource, enhancing enterprise applications and infrastructure services. Drive operational excellence, support cross-functional initiatives, and ensure reliable, sec...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$166K - $200K *

Lead impactful solutions as a Global Solution Architect, driving business value through strategic customer engagement and technical expertise. Collaborate with sales teams to architect innovative auto...

RemoteRemote

2 weeks ago

  •   15+ years exp.  •   Manufacturing & Automotive

$135K - $160K *

Champion innovative Salesforce Field Service solutions, leading implementations and integrations while mentoring teams and advising clients on optimization and transformation strategies for enhanced o...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.