Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$132K - $220K *

Join a team that's driving innovation in cloud technology and engineering excellence. Lead and mentor engineers while shaping strategic direction for Fan and Club products, ensuring high performance a...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$140K - $185K *

Drive technical excellence by developing standards and processes for commissioning, ensuring consistent execution across projects. Collaborate with cross-functional teams to enhance workforce capabili...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Join a team that's dedicated to delivering expert engineering solutions while managing projects safely and efficiently. Leverage your technical expertise to mentor others and drive innovation in gener...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$184K - $356K *

Unlock potential by developing innovative AI solutions and enhancing infrastructure capabilities. Collaborate with strategic partners to deliver hands-on technical support, ensuring optimal performanc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Drive growth by managing strategic enterprise accounts, navigating complex sales cycles, and building consensus among security-focused buying committees to secure multi-year contracts in a competitive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Transform enterprise data architecture through expert Azure platform engineering, enhancing reliability, governance, and cost-efficiency while collaborating with cross-functional teams to optimize dat...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Unlock your potential by supporting complex customer needs through expert solution design and seamless sales transitions. Collaborate with teams to drive sales opportunities and enhance customer engag...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $215K *

Unlock the potential of technical enablement by managing global projects, developing engaging content, and collaborating with teams to enhance enterprise security solutions and drive go-to-market succ...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Drive your career with a pivotal role managing technical partnerships, scoping integrations, and ensuring successful collaboration between engineering teams and partners. Shape strategic conversations...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Drive the development and support of healthcare interfaces and FHIR APIs, ensuring secure clinical data exchange. Collaborate with teams to implement solutions that enhance health information interope...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Take ownership of developing and supporting healthcare interfaces and FHIR APIs for a statewide Health Information Exchange, ensuring secure and reliable clinical data exchange across multiple healthc...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Empower your career by developing secure healthcare interfaces and FHIR APIs. Collaborate on a statewide Health Information Exchange, ensuring reliable clinical data exchange while supporting diverse...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Partner with us to deliver tailored solutions and in-depth demos, supporting a dynamic sales pipeline. Leverage your technical expertise to drive customer success and collaborate with teams to enhance...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$126K - $158K *

Empower innovation by building and deploying AI systems in real-world environments. Collaborate with customers to integrate vision AI solutions, ensuring reliable performance from prototype to product...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Help us advance our utilities and data center solutions by leading strategic customer partnerships, identifying market needs, and fostering scalable growth for a trusted workforce collaboration in cri...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Drive new logo acquisition and expansion revenue in key accounts, managing full-cycle sales from opportunity to contract. Collaborate with technical teams to build ROI models and ensure accurate forec...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Transform complex security architectures into compelling business narratives that resonate with enterprise decision-makers. Collaborate across teams to drive product positioning, messaging, and go-to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$105K - $150K *

Join a team that's transforming construction project management through technology. Leverage your industry expertise to guide customers in adopting Autodesk solutions, enhancing workflows, and driving...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$139K - $213K *

Grow your career with a dynamic team focused on driving strategic sales in the education sector. Leverage your expertise to engage C-suite executives, manage complex sales cycles, and exceed quotas wh...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $210K *

Lead the technical strategy and pre-sales organization for AI infrastructure, driving complex enterprise deals and shaping product roadmaps through customer insights and architectural expertise...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $120K *

Explore a pivotal role in leading complex analysis across systems, driving alignment among stakeholders, and enhancing technology solutions. Collaborate with diverse teams to translate business needs...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$157K - $185K *

Join a team that's building cutting-edge data infrastructure for enterprises. As a Forward Deployed Engineer, you'll create production-quality agents and integrations directly within customer environm...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $130K *

Transform your career by designing and delivering complex full-stack solutions using Java, Spring Boot, and Angular. Collaborate with teams to enhance engineering quality and lead technical initiative...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $192K *

Shape the future of amphibious warfare by managing GFE acquisition and configuration for LPD new construction. Collaborate with teams to ensure delivery performance and maintain system integrity throu...

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Drive innovative solutions by leveraging data analytics and strategic counsel to enhance client performance. Collaborate with high-performing teams to deliver tailored insights for transformational ev...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.