Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$77K - $118K *

Drive the evolution of scalable, secure platforms by architecting solutions that enhance network intelligence and application delivery, collaborating with cross-functional teams to optimize performanc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Elevate customer experiences by leading a team of engineers, providing strategic insights, and implementing innovative solutions in growth engineering and digital marketing for impactful delivery serv...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Shape the future of avionics sales by leading business development efforts, engaging military and commercial aerospace customers, and driving strategic growth in the Americas through innovative test s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$145K - $175K *

Join us to define and drive the enterprise cloud database strategy, leading architecture and modernization efforts to create scalable, reliable solutions for healthcare applications serving millions o...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Lead the charge in delivering innovative solutions as a Solutions Architect, guiding teams and customers through technical challenges while maximizing mission impact and enhancing customer experiences...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Drive transformative Salesforce solutions in higher education as a trusted advisor. Lead architecture design, align technology with institutional goals, and ensure successful delivery of Education Clo...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $140K *

Transform infrastructure and deployment modernization efforts, serving as a technical cornerstone for multiple programs. Drive DevSecOps maturity and cloud adoption while ensuring secure, rapid delive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$200K - $220K *

Lead the design and implementation of advanced systems and workflows for GTM teams. Drive technical initiatives to optimize scalability, leverage AI, and mentor engineers, ensuring robust architectura...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $150K *

Join a team that's engineering innovative cloud solutions, ensuring stability and performance while driving continuous improvement across scalable environments. Your expertise will shape the future of...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$89K - $155K *

Lead the design and implementation of a UiPath automation program, establishing governance and operational standards while collaborating with a diverse team to build a Center of Excellence from the gr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate incident response capabilities by developing dashboards and alerts, optimizing cloud performance, and ensuring security compliance. Collaborate with product teams to enhance IAM needs while dr...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$145K - $175K *

Shape the future of cybersecurity by leading Zero Trust architecture initiatives. Drive enterprise-wide strategies, develop reusable patterns, and ensure alignment with federal standards while guiding...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$127K - $212K *

Champion secure architecture by conducting reviews and assessments for cloud and on-premise systems. Leverage your cybersecurity expertise to design solutions that align with security best practices a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$120K - $145K *

Contribute to architectural guidance and technical support across diverse projects. Collaborate with teams to evaluate solutions, adapt to evolving technologies, and communicate findings effectively t...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$206K - $267K *

Transform your career by leading innovative architectural strategies and governance. As a trusted advisor, you will drive technology alignment and maximize investments while mentoring cross-functional...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Transportation

$120K - $130K *

Unlock potential by leading the design and optimization of secure cloud-native platforms. Collaborate across teams to enhance software delivery, implement CI/CD pipelines, and drive best practices in...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Accelerate your career by designing and optimizing secure, scalable cloud infrastructure. Collaborate with cross-functional teams to enhance operational efficiency and ensure high availability for glo...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$174K - $220K *

Pioneer significant enhancements in cloud infrastructure, optimizing capacity and performance. Drive cross-functional collaboration to ensure scalability and reliability while shaping best practices...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$104K - $156K *

Unlock your potential as a Solutions Engineer, driving sales success by leveraging technical expertise to address customer challenges and deliver F5 solutions. Collaborate with sales teams to achieve...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Transform traffic management by optimizing signal systems for efficient movement of people and goods. Collaborate with cross-functional teams to enhance product deployment and support, ensuring safety...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$135K - $160K *

Unlock potential by shaping mobile development solutions and guiding implementation teams to deliver projects following your architectural designs, ensuring quality and effectiveness throughout the de...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's enhancing data integration for the U.S. Coast Guard. As a Senior Systems Engineer, you'll lead the implementation and maintenance of the Cloud Data Pipeline, ensuring robust data sh...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$163K - $245K *

Shape security architecture by designing robust frameworks across various tech domains. Collaborate with cross-functional teams to ensure comprehensive cybersecurity solutions aligned with business go...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Champion AI deployment by designing and implementing innovative solutions across multiple platforms. Collaborate with teams to enhance customer experiences while ensuring data governance and security...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$83K - $125K *

Drive the operational health of mission-critical Appian environments, ensuring reliability and performance. Collaborate with cross-functional teams to manage configurations, deployments, and incident...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.