Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$145K - $193K *

Transform the marketing data landscape by leading the architecture and evolution of a scalable data platform. Drive innovation in analytics, AI, and operational frameworks to enhance marketing strateg...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$90K - $110K *

Engage with clients to design and implement tailored Manhattan WMS solutions, ensuring optimal performance and support throughout the project lifecycle. Leverage your expertise to transform supply cha...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K *

Take ownership of cybersecurity compliance initiatives, leading risk management and strategic advisory services to enhance client security programs and ensure adherence to regulatory standards across...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $100K *

Advance IT security by managing vulnerability scanning tools and processes, ensuring the integrity of USDA systems. Collaborate across teams to implement solutions, troubleshoot issues, and maintain s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Transform the Microsoft 365 ecosystem by designing and implementing integrations, enhancing data flow, and ensuring compliance. Collaborate with cross-functional teams to modernize processes and drive...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$114K - $151K *

Unlock potential by leading the HV overhead switchgear portfolio, driving product strategy, market development, and cross-functional collaboration to achieve profitable growth and enhance utility solu...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$122K - $183K *

Transform how we operate by leading technology-driven initiatives that enhance business capabilities. Collaborate with cross-functional teams to define product strategies and drive measurable outcomes...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $144K *

Lead the charge in designing and implementing advanced building automation systems for critical infrastructure projects, ensuring seamless integration and optimal performance while managing teams and...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$170K - $200K *

Transform customer experiences by providing technical expertise and solutions. Collaborate with sales and engineering teams to deliver impactful product demonstrations and address technical challenges...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$131K - $240K *

Shape the future of training and development in orthopedic medical devices, enhancing sales effectiveness and fostering strong partnerships across teams. Drive learning initiatives and support surgica...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $160K *

Join a team that's redefining application security by partnering with engineering leaders to influence secure design, conduct hands-on code reviews, and enhance security tooling, all while navigating...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform engineering processes by developing verification tools, dashboards, and shared infrastructure. Collaborate with teams to enhance quality checks and streamline workflows, ensuring efficient s...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $150K *

Unlock your potential as a key resource in power plant consulting, focusing on generator engineering. Collaborate with industry leaders to deliver innovative solutions while enjoying a flexible remote...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$75K - $158K *

Support SAP security in a DoD IL5 S/4HANA environment, enhancing Zero Trust architecture and system security. Collaborate with cyber and audit teams to solve complex challenges and ensure mission-crit...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $225K *

Lead and mentor a dynamic Security Operations team, overseeing incident response and SOC improvements while driving hands-on investigations and AI-assisted workflows to enhance security posture and op...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Empower global cybersecurity service delivery by leading client-focused operations, driving growth, and ensuring excellence in managed services. Foster a high-performing team while enhancing client ou...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $210K *

Transform procurement operations by managing and enhancing acquisition systems, ensuring compliance and efficiency while collaborating with stakeholders to implement effective business processes and p...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$70K - $117K *

Lead innovative structural engineering solutions for marine vessels, ensuring integrity and compliance with maritime standards. Collaborate with teams to enhance operational safety and performance in...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $120K *

Transform cloud security operations by enhancing AWS and Azure environments. Lead initiatives to secure cloud-native capabilities, manage incident responses, and collaborate with engineering teams to...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Lead the digitization and automation of manufacturing processes, enhancing equipment performance and quality through integration of operational technology and smart systems. Collaborate with cross-fun...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Business Services

$140K - $175K *

Transform the marketing landscape by leading strategic initiatives that drive brand authority, generate qualified leads, and accelerate revenue growth in the cybersecurity compliance sector for defens...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$94K - $266K *

Manage client relationships by delivering strategic Salesforce solutions, leveraging technology, optimizing processes, and mentoring junior team members to drive both immediate impact and long-term su...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Join a dynamic team as a Sr. Support Engineer, providing expert pre- and post-sales technical support for 5G solutions. Collaborate with customers and partners to resolve complex issues, enhance team...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Transportation

$120K - $145K *

Join a team that's redefining payroll solutions by leading Oracle Cloud HCM implementations. Collaborate with stakeholders to design scalable, best-practice solutions while mentoring teams and ensurin...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Staffing

$130K - $150K *

Take ownership of transformative AI solutions by embedding within business units, identifying key operational challenges, and rapidly delivering demonstrable results that drive adoption and innovation...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.