Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$96K - $144K *

Lead the charge in delivering exceptional customer service and technical support at assigned medical equipment sites, ensuring compliance with contracts and fostering strong client relationships throu...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$159K - $215K *

Take ownership of Windows endpoint reliability and lifecycle management. Enhance provisioning, patching, and automation while collaborating with cross-functional teams to drive improvements and mentor...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$106K - $160K *

Lead complex contract negotiations and drive strategic supplier relationships. Collaborate with stakeholders to assess risks, develop negotiation strategies, and enhance contracting practices while me...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$75K - $158K *

Shape the future of automation by managing the UiPath platform, ensuring security and performance while collaborating with cross-functional teams to deliver efficient robotic process solutions across...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Champion the migration to a modern Databricks lakehouse, designing robust data pipelines and ensuring data quality. Collaborate with teams to enhance analytics capabilities and set technical standards...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team as a Strategic Sales Engineer, driving sales growth through technical expertise and collaboration. Engage with sales leadership to create opportunities and deliver solutions across...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$97K - $145K *

Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K *

Join a dynamic team to manage client technologies, mentor peers, and deliver IT assessments. This hands-on role emphasizes client service and consultant development, ensuring optimal performance acros...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $158K *

Empower your career by joining a dynamic team focused on enhancing IT operations. Leverage your expertise in Momentum Financials to drive impactful solutions and collaborate with stakeholders in a hig...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Lead strategic sales initiatives across the Mid-West Territory, driving business growth through effective account management and relationship building. Collaborate cross-functionally to achieve sales...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $145K *

Drive impactful software solutions by embedding with clients, transforming ambiguous needs into deployable features across secure environments. Collaborate closely with users and stakeholders to deliv...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $149K *

Elevate your career by collaborating with top partners to drive technical sales, deliver impactful training, and enhance product adoption. Join a dynamic team focused on fostering creativity and accou...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Engineer innovative solutions as a Project Engineer, overseeing diverse projects from design to execution. Collaborate with teams to ensure quality standards and effective communication, driving conti...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Technical Services

$139K - $213K *

Join a team that's driving innovation in education technology by generating strategic opportunities and delivering tailored solutions to key decision-makers in the Mid-Atlantic region, ensuring except...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$169K - $253K *

Transform operational technology by leading the design and implementation of scalable SCADA and telemetry solutions, ensuring secure data delivery and operational visibility across multi-site environm...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Transform client experiences by leading the design and implementation of Oracle HCM Cloud solutions. Collaborate with teams to ensure scalable, reliable, and high-performance technical architectures t...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Staffing

$150K - $180K *

Lead the charge in designing and implementing innovative software systems for cutting-edge healthcare SaaS platforms, driving technical excellence and strategic collaboration across teams to achieve i...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$230K - $275K *

Lead the charge in vulnerability research and exploitation techniques, transforming real-world threats into automated solutions. Collaborate with teams to enhance security measures and validate defens...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$181K - $301K *

Transform your career by leading a global cyber defense team, driving proactive strategies to mitigate risks and enhance security across diverse environments. Collaborate with cross-functional teams t...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Transform the engineering landscape by owning architecture, deployment, and incident management. Collaborate with teams to prioritize features, enhance payment systems, and integrate AI, all while ens...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $155K *

Join a team that's redefining energy solutions by designing innovative fluid and power systems. As a Process Engineer, you'll drive the development and optimization of cutting-edge technologies in a f...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$114K - $200K *

Champion growth by leading the Enterprise Sales team, driving member acquisition, and executing strategic sales initiatives in the cybersecurity sector. Collaborate with stakeholders to enhance sales...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in transforming client operations by identifying and accelerating AI-driven opportunities. Collaborate with stakeholders to frame business challenges, prototype solutions, and drive me...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.