Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$100K - $140K *

Lead operational procurement for network infrastructure and data-center projects. Collaborate with cross-functional teams to source suppliers, negotiate contracts, and ensure compliance with procureme...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Lead comprehensive evaluations of federally subsidized housing, ensuring compliance with safety and accessibility standards. Collaborate with inspectors to enhance operational performance and resolve...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Transportation

$155K - $241K *

Join us to shape the future of platform engineering by driving strategic initiatives, influencing organizational architecture, and enhancing developer experience across a multi-cloud environment. Your...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Information Technology

$160K - $200K *

Join a team that's redefining cloud operations by leading a unified infrastructure organization. Drive platform reliability, cost efficiency, and operational excellence while collaborating with cross...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Consumer Technology

$150K - $300K *

Transform enterprise operations by developing AI solutions tailored to customer needs. Engage directly with clients, manage the full technical lifecycle, and drive measurable improvements in AI perfor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $180K *

Optimize procurement processes and vendor relationships, ensuring effective contract management and risk mitigation in a dynamic technology environment. Collaborate with cross-functional teams to secu...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $175K *

Lead the charge in integrating acquisitions by developing operational capabilities, ensuring seamless transitions, and driving performance improvements across multiple functions to enhance customer re...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in optimizing enterprise middleware platforms through effective administration, automation, and security management, ensuring high availability and compliance while enhancing operation...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $280K *

Join us to architect and build a cutting-edge web platform, driving marketing innovation through AI agents. Own technical decisions, enhance user experiences, and ensure seamless integration with our...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform clients' digital strategies by leading pre-sales initiatives. Engage, inspire, and coach stakeholders through innovative solutions, ensuring alignment with business goals and implementing At...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Advance payer integrations by managing complex processes and relationships. Drive outreach and research to establish direct connectivity with 3,000+ payers, ensuring accurate data and efficient handof...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$121K - $182K *

Lead the charge in designing and optimizing secure Azure Virtual Desktop environments. Collaborate with cross-functional teams to ensure high availability and performance, delivering top-quality solut...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$112K - $179K *

Join a dynamic team to lead security engineering initiatives, ensuring robust protection of cloud infrastructure and sensitive data while driving compliance and mission success in complex federal envi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$90K *

Develop and maintain IT infrastructure solutions, ensuring optimal performance and security. Collaborate with teams to implement software, provide training, and enhance systems, while driving innovati...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Partner with us to design and implement engaging front-end experiences for leading eCommerce brands. Leverage your skills in Figma and Shopify to create custom loyalty solutions, collaborating closely...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Unlock your potential as you drive Oracle EPM Cloud Planning solutions, supporting clients in their transformations. Leverage your expertise to configure, implement, and coach while enhancing project...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$144K - $184K *

Transform strategic accounts by driving sales and fostering executive relationships. Leverage deep industry knowledge to identify opportunities and enhance client satisfaction, ensuring growth and ret...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

$125K - $150K *

Join a team that's shaping the future of enterprise solutions by leveraging your technical expertise to deliver high-quality Open Text implementations for enterprise clients, ensuring tailored solutio...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $120K *

Join a team that's dedicated to optimizing sales solutions through technical expertise. Collaborate with cross-functional teams to develop proposals, evaluate technologies, and manage multiple project...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in crafting transformative data solutions by harnessing deep expertise in Salesforce Data 360 and enterprise architecture. Collaborate with clients to ensure scalable solutions that me...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $135K *

Shape the future of digital services by developing user-centric applications and enhancing software engineering practices. Collaborate with cross-functional teams to deliver impactful solutions for fe...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Engage with our team as a Senior Services Engineer, driving B2B integration and managed file transfer solutions. Ensure operational excellence and reliability in mission-critical systems while providi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$105K - $175K *

Lead the charge in Model-Based Systems Engineering, collaborating with experts across diverse domains to develop cutting-edge solutions. Utilize your skills in SysML and modeling tools to drive innova...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$125K - $150K *

Drive platform architecture and strategy, owning scalable production environments. Lead cross-team collaboration, mentor engineers, and advocate for DevSecOps practices while solving complex technical...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.