Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$297K - $367K *

Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Empower a dynamic OSP Engineering team to deliver innovative network solutions. Lead diverse projects, ensuring compliance and quality while fostering collaboration across functions to enhance custome...

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$95K - $115K *

Lead the OSP Engineering team to develop and implement innovative network solutions, ensuring high-quality service delivery and compliance with industry standards while fostering collaboration across...

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$140K - $175K *

Drive the development of innovative AI and data solutions, enhancing enterprise data platforms while ensuring scalable, quality delivery. Collaborate with teams to define technical architecture, shapi...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$115K - $130K *

Join a dynamic team as you provide essential IT support to a distributed workforce. Leverage your troubleshooting skills to resolve technical issues, enhance user experience, and contribute to a colla...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Join a team that's passionate about security innovation, focusing on penetration testing and threat modeling across diverse technologies. Leverage your expertise in software and hardware analysis to t...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$170K - $220K *

Drive your career forward by leading cross-functional deployment strategies. This senior role requires exceptional judgment and communication skills to navigate complex, ambiguous situations and deliv...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $130K *

Transform cybersecurity practices by leading vulnerability management and penetration testing efforts. Collaborate with cross-functional teams to enhance security controls, reduce risks, and ensure ro...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Champion security excellence by leading complex Microsoft Sentinel and Defender XDR implementations. Drive technical enablement projects, mentor engineers, and enhance client security practices in a d...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by designing and managing Azure infrastructure, ensuring seamless hybrid connectivity and robust disaster recovery. Collaborate across teams to enhance operations, automate processes...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$140K - $160K *

Accelerate progress at our integration platforms, ensuring scalable, reliable data flows. You'll design, build, and optimize workflows while collaborating across teams to enhance performance and custo...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$74K - $87K *

Transform client implementations by leading discovery, planning, and execution. Own project scope, timelines, and budgets to ensure successful adoption of solutions that align with business goals and...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$157K - $283K *

Lead the charge in driving business growth by developing strategic partnerships and innovative solutions for federal clients, while collaborating with cross-functional teams to deliver exceptional res...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$144K - $200K *

Unlock potential by managing end-to-end technical deployments of computer vision systems. Collaborate with clients in diverse environments to ensure seamless production operations and enhance system p...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Staffing

$165K - $260K *

Drive the development of an intelligent content delivery network, optimizing web performance through cutting-edge infrastructure and AI. Collaborate with a lean team to transform complex problems into...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$114K - $143K *

Drive operational excellence as a Program Manager, enhancing EPD processes and collaboration. Leverage data insights to identify trends, improve efficiency, and support cross-functional teams in a dyn...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $97K *

Shape the future of digital experiences by delivering innovative web solutions that enhance member engagement and drive growth. Collaborate with cross-functional teams to create intuitive, high-qualit...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $170K *

Join a dynamic team to optimize operational systems, drive growth, and enhance performance across departments. Collaborate with leadership to ensure strategic goals translate into measurable results a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $212K *

Pioneer innovative IAM strategies to enhance security across cloud and on-premise infrastructures. Collaborate with cross-functional teams to implement robust identity governance and access management...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$207K - $290K *

Elevate your career by leading a dynamic Applied AI team, transforming innovative AI solutions into production-ready systems within a regulated financial environment, while collaborating across depart...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Partner with us to design and implement cloud-native data solutions, ensuring secure and reliable data exchange across platforms. Collaborate with teams to enhance data accessibility and support advan...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$117K - $195K *

Join a team that's developing cutting-edge avionics architectures for diverse missions. Leverage your expertise in command and data handling to optimize system performance and ensure seamless integrat...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$225K - $265K *

Unlock your potential as a technical leader, driving innovative solutions in Web Application Firewall integration. Collaborate across teams to enhance security and deliver impactful customer outcomes...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Take ownership of large-scale construction projects, managing stakeholders and ensuring compliance. Oversee project governance, track milestones, and enhance processes while fostering client relations...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$142K - $161K *

Unlock potential by automating IT processes and workflows. In this senior role, you'll own and enhance automation systems, ensuring reliability and efficiency while collaborating with cross-functional...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.