Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$165K - $185K *

Lead the charge in healthcare data integration by analyzing source systems, designing database objects, and ensuring compliance with governance policies to support the Corporate Data Warehouse...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in automating and scaling network infrastructure across diverse global datacenters, enhancing performance and security while collaborating with engineering teams to implement robust so...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Empower a robust enterprise network-security infrastructure by leading initiatives in design, operation, and troubleshooting of advanced firewall systems. Collaborate with cross-functional teams to en...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$147K - $190K *

Lead the charge in defining and guiding enterprise architecture across product systems and business applications. Collaborate with cross-functional teams to translate strategy into actionable designs...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $160K *

Join us to lead innovative Oracle Cloud solutions, collaborating with clients to design and deliver cutting-edge technical architectures that address complex business challenges and drive success in a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$174K - $224K *

Empower organizations by shaping data governance strategies that enhance security, compliance, and operational resilience. Collaborate with cross-functional teams to deliver impactful governance solut...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Engineer scalable Azure data solutions, leading architecture and modernization initiatives. Collaborate with teams to define standards and ensure high-performance data integration, governance, and sec...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$266K - $399K *

Elevate your career by providing technical leadership and expertise in cloud, AI, and DevOps. Collaborate with sales teams to deliver innovative solutions, mentor peers, and drive customer success acr...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $180K *

Empower teams by leading the technical vision and delivery standards for ServiceNow. Drive high-quality implementations across engagements while mentoring talent and collaborating with management to e...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$130K - $160K *

Lead the design and development of robust security architecture for cloud infrastructure and CI/CD pipelines. Partner cross-functionally to embed security in the development lifecycle and evaluate eme...

United StatesRemote

Reposted 1 month ago

  •   8 - 10 years exp.  •   Media

$94K - $266K *

Empower customer success by designing and implementing AWS Connect solutions, conducting technology assessments, and leading project communications to enhance contact center operations and agent produ...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$224K - $431K *

Join a team that's redefining AI networking by driving innovation in performance and scalability of distributed systems, optimizing data processing for large language models and generative AI workload...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$181K - $226K *

Join our dynamic team as a Software Engineer, where you'll enhance internal tools, collaborate with stakeholders, and drive improvements in cloud infrastructure and observability, all while working in...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Elevate technical leadership in military health solutions, driving proposal development and architecture design. Collaborate with cross-functional teams to create innovative, compliant solutions that...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$168K - $240K *

Champion AI strategy and governance by leading advisory consulting services, guiding clients from interest to practical adoption. Collaborate with technical teams to deliver integrated solutions and e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $185K *

Reimagine legal workflows as an AI Solutions Architect, driving AI adoption in law firms. Collaborate with teams to design and implement innovative solutions, enhancing efficiency and client advocacy...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$150K - $180K *

Join us to tackle complex challenges as a strategic technical leader, influencing product direction and driving customer success. Your expertise will shape innovative solutions while engaging directly...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$320K - $405K *

Design and oversee the electrical architecture for cutting-edge data centers, ensuring robust power distribution and integration of advanced technologies. Collaborate with partners to enhance prefabri...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $251K *

Pioneer innovative technology strategies and architectural solutions across Agile teams, driving AI-enabled engineering transformation and ensuring scalable, secure, and maintainable solutions for ent...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $212K *

Elevate AI security by designing robust frameworks to protect systems from threats. Collaborate with cross-functional teams to ensure compliance and ethical use, while implementing strategies that saf...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$150K - $160K *

Unlock potential by designing and optimizing enterprise database environments for mission-critical HRIT applications, ensuring security, scalability, and compliance with federal standards while collab...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $170K *

Unlock the potential of enterprise data architecture by designing secure, scalable solutions for employee data using Databricks. Collaborate with cross-functional teams to implement governance, compli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$115K - $150K *

Architect and streamline cloud network infrastructure. Support robust security and connectivity across Azure, OpenShift, and SASE platforms. Collaborate with cross-functional teams, ensuring optimal p...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$103K - $154K *

Unlock advanced data solutions by leveraging Microsoft Azure and Power BI. Collaborate with teams to deliver high-quality analytics and reporting, while enhancing business intelligence capabilities th...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.