Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
$160K - $200K *
Drive innovation by designing and developing scalable backend services, collaborating closely with engineering teams to enhance platform performance and reliability while mentoring junior developers a...
3 weeks ago
Senior/Staff DevOps Engineer, Federal
$180K - $240K *
Join us to build and operate secure infrastructure for federal and partner environments. This hands-on role focuses on Kubernetes, infrastructure as code, and production support, ensuring reliable dep...
5 days ago
Clinical Account Executive (RPh) - Archimedes
$100K - $120K *
Bring your expertise to a dynamic role as a Clinical Account Executive, where you'll lead specialty medication management, collaborate with healthcare professionals, and drive formulary development to...
Today
Data Center Operations System Engineer - Plano, TX
$95K - $115K *
Advance your career by ensuring optimal performance of critical data center infrastructure. Collaborate with teams to troubleshoot, document, and manage hardware and software systems in a fast-paced e...
1 week ago
$96K - $115K *
Lead the charge in designing and developing aerospace wire harnesses, ensuring compliance with industry standards while collaborating with multidisciplinary teams to deliver innovative solutions...
Reposted yesterday
$75K - $158K *
Contribute to the security of critical Oracle systems by designing and implementing cyber controls. Collaborate with teams to ensure compliance, support testing phases, and produce quality deliverable...
Reposted 2 weeks ago
$95K - $115K *
Lead and enhance day-to-day accounting operations, focusing on accounts payable, receivable, and cash management. Collaborate with cross-functional teams to ensure accurate, timely transactions while...
1 week ago
Consulting Solution Executive – Hybrid Infrastructure
$91K - $127K *
Unlock your potential by driving growth in Hybrid Infrastructure solutions. Lead strategic account management, cultivate relationships, and enhance market presence while achieving sales targets in a d...
3 weeks ago
$125K - $140K *
Elevate your career by designing and managing AWS environments, automating CI/CD, and ensuring robust application delivery. Collaborate with cross-functional teams for end-to-end ownership and enhance...
Reposted 2 days ago
$145K - $185K *
Transform the Cyber operations landscape by leading business development, shaping solutions, and executing contracts. Build trusted relationships, manage a diverse portfolio, and drive customer satisf...
Reposted 1 week ago
$95K - $115K *
Execute comprehensive project controls to ensure timely, budget-compliant project completion. Collaborate with teams to analyze financial data, manage forecasts, and report on project progress across...
2 weeks ago
$104K - $166K *
Optimize your career by ensuring the performance and scalability of critical AWS platforms. Collaborate with cross-functional teams to deliver secure, automated solutions while enhancing operational e...
6 days ago
$104K - $166K *
Elevate the performance and reliability of critical AWS cloud platforms. Collaborate with cross-functional teams to optimize infrastructure, automate processes, and ensure secure, scalable solutions t...
1 week ago
Technical Application Engineer - Industrial Communications products (MDS and Lentronics)
$89K - $148K *
Drive technical solutions by collaborating with sales teams and customers to enhance industrial communications products. Develop sales strategies, manage customer relationships, and ensure compliance...
Reposted 2 weeks ago
Software Engineer 5 - Training Platform, AI Platform
$466K - $500K+*
Join a team that's shaping the future of AI by designing and building scalable platforms for large-scale machine learning model training, enhancing performance, and creating user-friendly experiences...
6 days ago
Senior Security Consultant, Application Security
$75K - $175K *
Advance application security initiatives by leading manual code reviews, penetration tests, and threat modeling. Work closely with clients to strengthen their secure development processes, delivering...
Reposted 4 weeks ago
ServiceNow Moveworks Developer & Architect
$120K - $145K *
Lead the design and implementation of Moveworks AI solutions, integrating with ServiceNow to enhance enterprise workflows. Collaborate with teams to deliver innovative, scalable solutions that transfo...
2 weeks ago
Enterprise Support Engineer (West Coast)
$110K - $130K *
Unlock potential by providing expert technical support for enterprise clients. You'll bridge engineering and customer success, resolving complex issues, analyzing system performance, and enhancing cli...
Reposted 1 week ago
$138K - $201K *
Architect cloud-based data solutions and drive enterprise data strategy. Leverage advanced analytics and modern data architectures to enhance operational efficiency and compliance in healthcare data m...
3 weeks ago
$90K - $110K *
Optimize software delivery by developing and maintaining CI/CD pipelines, automating deployment processes, and enhancing system reliability. Collaborate with teams to streamline operations and support...
2 weeks ago
$95K - $115K *
Engineer innovative power interconnect solutions by collaborating with customers and internal teams. Drive technical discussions, translate architecture needs, and support product development to enhan...
1 week ago
$184K - $356K *
Innovate at the forefront of AI infrastructure validation by designing and implementing robust tooling for cluster readiness and certification, ensuring optimal performance for GPU deployments in prod...
1 week ago
Staff Software Engineer, AI Systems
$188K - $265K *
Accelerate progress at the forefront of AI infrastructure by leading technical direction, ensuring platform architecture meets company ambitions, and fostering collaboration across engineering teams f...
Reposted 6 days ago
Principal Subcontract Administrator (Remote)
$112K - $196K *
Lead the Subcontracts team in managing complex agreements, ensuring compliance and fostering relationships with suppliers and clients. Drive negotiations, oversee proposal evaluations, and provide str...
2 weeks ago
$90K - $175K *
Empower mission success by managing COMSEC lifecycle functions, ensuring the security and integrity of communication systems through expert oversight and compliance with national standards...
Reposted today
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.