Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$110K - $130K *

Champion complex network installation projects by leading teams, mentoring technicians, and ensuring high-quality service delivery. Collaborate with project managers and customers to meet objectives w...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$190K - $210K *

Explore innovative solutions as you lead the design and architecture of scalable healthcare applications, mentor engineers, and collaborate with cross-functional teams to enhance patient experiences a...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$117K - $143K *

Empower small businesses by developing AI solutions that streamline workflows. Collaborate closely with customers to identify challenges and create impactful software that enhances efficiency and driv...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Shape the future of cybersecurity in higher education by delivering expert assessments, advisory services, and tailored remediation plans that empower institutions to enhance their security posture an...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$106K - $176K *

Optimize enterprise database services in a secure hybrid-cloud environment. As a senior technical resource, ensure performance, security, and reliability while supporting cloud adoption and modernizat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$142K - $215K *

Elevate your career by driving new business growth in a dynamic sales environment. Own the full sales cycle, collaborate with teams, and exceed revenue goals while engaging with key stakeholders in a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Engineer robust backend systems for financial applications, tackling payments, fraud detection, and compliance. Collaborate with a skilled team to design, build, and optimize features, ensuring reliab...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Transform your career by enhancing data security and integrity. Collaborate with cross-functional teams to implement robust security measures, conduct audits, and mitigate risks while staying ahead of...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining AI solutions by rapidly delivering innovative, client-focused engagements. Collaborate with stakeholders to architect impactful agentic solutions that drive business valu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Elevate your career by leading a dynamic engineering team in fire alarm design. Drive innovative solutions, optimize project performance, and collaborate across departments to ensure compliance and qu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive innovative software solutions by designing, developing, and testing systems-level software. Collaborate with cross-functional teams to meet operational specifications and enhance SAP functionali...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Staffing

$145K - $160K *

Drive innovation by building scalable data integration solutions, collaborating with cross-functional teams to enhance healthcare technology. Ensure data quality and security while optimizing performa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Elevate team performance by leading a Scrum team in developing and modernizing enterprise SaaS applications. Guide technical decisions, mentor engineers, and foster collaboration across departments to...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Drive AI-native software development by architecting systems, guiding AI agents, and ensuring quality. Collaborate closely with users to transform business needs into reliable, efficient solutions whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Drive partner success by developing key relationships and executing strategic business plans in the Latin America region, enhancing revenue through effective channel programs and collaboration with sa...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$255K - $295K *

Lead the technical direction for foundational services, guiding architecture and execution across teams to enhance platform capabilities for customer and partner experiences. Mentor engineers and infl...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a dynamic team to oversee CMMC compliance, ensuring strategic coordination across stakeholders and technical teams. Drive project execution, monitor KPIs, and facilitate continuous improvement in...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Unlock potential by leading complex engineering initiatives across Microsoft 365 collaboration services, ensuring secure, reliable solutions while mentoring engineers and enhancing platform health thr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Lead data center projects from inception to completion, ensuring quality, safety, and budget adherence. Collaborate with teams and stakeholders to deliver successful outcomes while fostering a strong...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Drive successful data center projects from inception to completion, overseeing teams, budgets, and schedules while ensuring safety and quality standards are met throughout the construction process...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Lead cloud architecture and platform engineering, balancing strategic vision with hands-on technical execution. Drive team growth, ensure compliance, and enhance infrastructure for secure healthcare s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$121K - $182K *

Partner with us to lead complex cloud migrations, ensuring technical readiness and seamless execution across Azure and AWS environments while driving innovative solutions and high-quality outcomes in...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $190K *

Shape the enterprise architecture landscape by aligning technology across core platforms, establishing standards, and driving strategic initiatives. Collaborate with cross-functional teams to enhance...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team to build and grow channel partnerships, driving revenue through strategic alliances with cloud providers. Leverage your expertise to recruit, enable, and activate partners while co...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $190K *

Deliver strategic assessments and solutions for federal information systems, ensuring compliance with NIST RMF and related standards. Collaborate with stakeholders to identify security gaps and provid...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.