Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$157K - $174K *

Join a team that's shaping the future of combat vehicle software. Lead architectural design and technical direction for mission-critical systems, integrating advanced technologies in a collaborative...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$115K - $120K *

Empower cybersecurity excellence by developing and maintaining policies that align with federal standards. Collaborate with stakeholders to ensure compliance and enhance governance within a dynamic te...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$85K - $111K *

Optimize infrastructure solutions by leading cross-functional teams to design, implement, and support resilient systems. Collaborate with diverse stakeholders to ensure timely delivery and operational...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$170K - $200K *

Drive impactful legal strategies by leveraging your expertise in intellectual property and technology transactions. Join a dynamic team to negotiate contracts and advise on legal matters, contributing...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $125K *

Drive growth in the Data Center market by leading sales strategies, developing key relationships, and executing innovative initiatives to achieve market leadership in the West region. Shape the future...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $171K *

Lead the charge in building and executing a comprehensive commissioning program for Modular Data Centers, ensuring optimal performance from factory testing to operational handover while collaborating...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$108K - $130K *

Innovate the go-to-market systems by building AI agents and infrastructure that drive pipeline efficiency, ensuring seamless integration and reliability across sales and marketing operations...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Transportation

$180K - $225K *

Lead the charge in transforming AI strategies into impactful solutions for revenue teams, collaborating closely with GTM leaders to drive innovation and measurable outcomes while enhancing engineering...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $135K *

Join a team that's dedicated to enhancing federal cybersecurity compliance through advanced risk management and governance. Leverage your expertise to conduct assessments, manage authorizations, and e...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Deliver impactful telecom design solutions by overseeing projects, enhancing production efficiency, and collaborating with designers and project managers to meet quality standards and client expectati...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$102K - $170K *

Lead the charge in full-stack development, collaborating on enterprise modernization with Microservices. Deliver high-quality software, mentor engineers, and ensure best practices for cloud technologi...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$99K - $120K *

Join our innovative team to architect and deliver cutting-edge IoT systems for special projects. You'll drive initiatives from concept to field pilot, integrating advanced technologies in a dynamic, c...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$218K - $273K *

Champion the global technical alliance with Snowflake and Databricks, driving co-sell revenue through strategic planning, technical narratives, and collaborative execution across teams and events, whi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $90K *

Join a team that's dedicated to delivering exceptional technical support for complex technologies, ensuring global customer satisfaction and product quality through collaborative troubleshooting and i...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$90K - $110K *

Join a team that's dedicated to enhancing digital experiences for a Federal Government program. As a Web Developer, you'll build and maintain websites, ensuring accessibility and performance while col...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $158K *

Unlock potential by serving as a key Business Analyst/Product Manager in a Scaled Agile environment, translating business objectives into actionable features and capabilities, while collaborating acro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Explore a pivotal role in shaping cloud infrastructure and DevOps practices. Lead initiatives to enhance software delivery, optimize processes, and mentor teams while ensuring compliance and security...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $216K *

Lead the technical implementation of a large-scale platform modernization program, ensuring adherence to architectural standards and providing hands-on guidance across multiple teams and vendors for s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Engineer innovative data solutions to optimize population health, enhance quality care analytics and reporting, while ensuring data governance and compliance within the healthcare domain. Collaborate...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Champion customer success by leading enterprise deployments and integrations. Drive technical direction and enhance automation for cloud services, ensuring seamless operations and improved customer ex...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$112K - $179K *

Optimize cloud infrastructure and CI/CD processes as a Cloud DevOps Engineer. Collaborate with Agile teams to enhance security, automate deployments, and ensure mission-critical support while leveragi...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$150K - $200K *

Engage in leading a dynamic team dedicated to delivering top-notch offensive security engagements, ensuring delivery quality and client satisfaction, while collaborating with sales to expand accounts...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $165K *

Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$127K - $237K *

Join a team that's driving digital transformation by enhancing products and services, managing strategic initiatives, and developing talent to achieve organizational goals while ensuring optimal perfo...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$163K - $245K *

Optimize enterprise application delivery and security solutions by partnering with key stakeholders to design and implement modern architectures across multi-cloud environments, driving innovation and...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.