Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$200K - $250K *

Shape the future of enterprise solutions by bridging technical expertise and strategic vision. Collaborate with cross-functional teams to design impactful architectures that drive customer success and...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$175K - $195K *

Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$116K - $155K *

Transform enterprise applications through strategic architecture, integration, and governance. Collaborate with stakeholders to enhance business processes and ensure reliable operation of platforms wh...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$101K - $135K *

Join a team that's shaping the future of healthcare technology by designing and enhancing our build and delivery infrastructure. Collaborate with architects and developers to implement best practices...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion high-availability network infrastructure by designing, deploying, and supporting Cisco solutions across manufacturing and warehouse facilities, ensuring optimal performance and security throu...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$125K - $200K *

Join a team that's redefining architectural excellence by leading global projects, driving business growth, and fostering client relationships while overseeing studio operations and strategic initiati...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Unlock potential by leveraging your Salesforce expertise to design, build, and review secure, scalable solutions. Collaborate with clients and teams to ensure seamless integrations and effective deliv...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by designing and optimizing enterprise data solutions in a Databricks Lakehouse environment, supporting critical missions with a focus on scalability and best practices...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Transform enterprise integration strategies into actionable architectures, ensuring secure, scalable connectivity across applications and data platforms. Collaborate with cross-functional teams to est...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$160K - $200K *

Transform security architecture by defining standards, leading reviews, and managing risks. Collaborate with teams to ensure secure, efficient integration of applications and AI, while maintaining cle...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$175K - $222K *

Engage in architecting high-volume autonomous agent pipelines, ensuring safety, performance, and compliance. Own the generator-verifier architecture and CI/CD processes while setting engineering stand...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$104K - $156K *

Drive security architecture across AWS and Azure, ensuring secure configurations and compliance. Collaborate with teams to implement standards, review designs, and maintain documentation as the cloud...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$66K - $106K *

Contribute to data-driven decision-making by designing and optimizing analytic solutions. Leverage your expertise in SQL and Tableau to transform raw data into actionable insights for mission-critical...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$105K - $160K *

Empower channel partners by providing technical leadership and solution architecture expertise focused on HPE Aruba technologies. Drive sales engagement and architect resilient infrastructure solution...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$95K - $115K *

Advance your career by optimizing and supporting a Student Information System. Collaborate with teams to enhance configurations, ensure compliance, and drive continuous improvement while delivering ex...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$112K - $179K *

Join a team that's shaping enterprise security architectures to protect vital information systems. You'll design, govern, and implement security solutions across diverse environments, ensuring complia...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$154K - $232K *

Transform enterprise cloud strategies by leading large-scale migrations to Azure and AWS. Collaborate with global teams to establish architecture standards, ensure security, and drive innovative solut...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $155K *

Lead the charge in architecting innovative End User Computing solutions, collaborating with account teams and clients to drive strategy, deliver presentations, and enhance customer experiences while e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Join a team that's redefining data center architecture by leading innovative design and execution of cutting-edge facilities. Collaborate across disciplines to deliver scalable, efficient solutions th...

4 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $180K *

Join a team that's redefining construction technology by architecting scalable, reliable systems that integrate cutting-edge AI and computer vision. Collaborate across disciplines to drive innovation...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $250K *

Accelerate progress at the forefront of AI technology by building and operating a secure, production-grade platform. Collaborate with business teams to transform AI capabilities into measurable value...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$165K - $185K *

Lead the charge in transforming organizations through AI adoption. Collaborate with cross-functional teams to design and implement innovative solutions that enhance productivity and drive measurable o...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $140K *

Lead the charge in designing and implementing advanced network security solutions, focusing on Zero Trust principles and SD-WAN architecture. Collaborate with cross-functional teams to enhance network...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$165K - $243K *

Deliver innovative disaster recovery solutions for healthcare systems, ensuring compliance and resilience for clinical workloads. Collaborate with cross-functional teams to address complex challenges...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Drive the design and optimization of network infrastructure, ensuring reliability and security. Collaborate with IT teams to develop policies, troubleshoot issues, and maintain compliance with best pr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.