Mission Systems Engineer Jobs

At Ladders, we connect you with the best available Mission Systems Engineering jobs that pay over $100,000 a year. Mission Systems Engineers play an essential role in the development, operation, and application of both hardware and software systems in aerospace and defense sectors.

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With listings from a wide variety of industries, you can find a position that fits your unique skill set. Quality assured with vetted opportunities from leading companies.

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Aim for the stars with high salaried jobs in Mission Systems Engineering. Leverage your expertise to land a six-figure job that matches your career goals.

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$90K - $120K *

Partner with us to design analytical solutions that drive public health outcomes. Lead multi-stakeholder projects supporting the 988 Crisis Lifeline, translating complex data into strategic insights f...

US-AnywhereRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$160K - $260K *

Join a team that optimizes customer data center environments by designing tailored infrastructure solutions. Collaborate with account teams, OEMs, and clients to uncover technology opportunities acros...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$130K - $180K *

Tackle the future of enterprise AI solutions by leading a talented team to innovate on Microsoft Azure. Architect scalable platforms, enhance business operations, and cultivate a high-performance engi...

US-AnywhereRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $95K *

Champion a safety-first culture within the highway assistance program, ensuring the safety of operators and motorists through effective training, regular audits, and compliance with safety regulations...

US-AnywhereRemote

6 days ago

  •   Less than 5 years exp.  •   Transportation

$118K - $155K *

Join a dynamic team as you drive service excellence for Varian Linear Accelerators. Engage in troubleshooting, maintenance, and repairs while supporting hospitals in Western Massachusetts and ensuring...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$109K - $150K *

Unlock potential by partnering with customers to solve complex challenges. As a trusted advisor, you'll lead technical solutions from discovery to deployment, collaborating with cross-functional teams...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$104K - $130K *

Unlock your potential in this dynamic role focused on power systems for mission critical facilities. Collaborate with engineers, execute studies, and drive project success with minimal supervision whi...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $130K *

Engage a dedicated team to lead configuration activities, ensuring accurate claims database implementation, adherence to health plan requirements, and strategic operational improvements, while fosteri...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $220K *

Innovate by designing and operating scalable data infrastructure for petabytes of data, enabling customer-facing features and analytics across global industries, while enhancing systems for reliabilit...

US-AnywhereRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$126K - $163K *

Optimize your career by joining a team dedicated to building a scalable data platform. Collaborate across engineering and data science to process massive datasets, ensuring operational excellence and...

US-AnywhereRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$147K - $220K *

Elevate your career by leading clinical study projects, ensuring quality and compliance while managing budgets and timelines. Collaborate with teams and clients to drive success in complex, global tri...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$163K - $245K *

Engineer the success of clinical study projects by managing scope, budget, and quality. Drive collaboration among teams and clients to ensure timely deliverables, implement rigorous risk management, a...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$147K - $220K *

Join a team that's dedicated to delivering high-quality clinical study projects. As a Senior Project Manager, you will lead project execution, ensuring adherence to timelines, budgets, and quality sta...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$105K - $130K *

Transform SCADA project management by overseeing successful integrations of renewable energy assets across North America, Latin America, and Europe. Lead teams and engage stakeholders ensuring timely...

US-AnywhereRemote

Reposted today

  •   5 - 7 years exp.  •   Energy & Utilities

$200K - $250K *

Champion the design and implementation of hybrid cloud architectures to optimize VA infrastructure. Collaborate across teams to deliver secure, scalable solutions while ensuring compliance with federa...

US-AnywhereRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$90K - $120K *

Engage in designing and developing innovative web and mobile applications, taking full ownership throughout the software lifecycle. Collaborate with a multidisciplinary team to create impactful digita...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$200K - $270K *

Unlock revenue potential as you engage C-level clients, drive strategic technology solutions, and foster partnerships in higher education and public sectors. Collaborate with teams to achieve transfor...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $130K *

Join a team that's architecting and customizing an enterprise AI search platform, engaging with clients to implement and enhance solutions, and collaborating with cross-functional teams to ensure impa...

US-AnywhereRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $150K *

Join a team that defines the architecture for AI-augmented engineering, guiding Fortune 500 clients from traditional practices to innovative agentic workflows in a high-impact, client-facing role...

US-AnywhereRemote

4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$100K - $150K *

Innovate with advanced AI solutions as you lead critical transformations for global enterprises. Enter the dynamic realm of agentic systems, shaping future workflows while consulting Fortune 500 clien...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $150K *

Lead the design and development of AI-augmented solutions, guiding Fortune 500 clients in transitioning to innovative agentic workflows. Own both strategic consulting and hands-on software engineering...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Lead the charge in transforming enterprise-level AI integration by architecting agentic workflows and delivering high-impact solutions for Fortune 500 clients, ensuring their transition to AI-augmente...

US-AnywhereRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Join a team that's redefining software development by leading AI integration in global enterprises. Drive innovative agentic workflows as a strategic consultant and technical lead in fast-paced, clien...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $150K *

Optimizing enterprise AI adoption, you'll architect agentic workflows, serve as a strategic consultant, and lead technical implementation for Fortune 500 clients, ensuring seamless transitions to AI-e...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Shape enterprise AI solutions as a Full-Stack Engineer driving innovation and productivity. Lead client projects in architecting agentic workflows and modern development strategies for Fortune 500 com...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What does a Mission Systems Engineer do?question toggle

    A Mission Systems Engineer designs, maintains and enhances a variety of systems that are crucial for accomplishing a mission. This includes airborne systems, weapons systems, communication systems, and more.

  • How much can a Mission Systems Engineer earn?question toggle

    The salary for a Mission Systems Engineer can vary depending on experience and location, but jobs listed on Ladders pay $100,000 or more.

  • What types of companies hire Mission Systems Engineers?question toggle

    Industries such as Aerospace, Defense, IT, and Engineering Apps, among others, consistently need qualified Mission Systems Engineers.