Microsoft Systems Engineer Jobs

Discover Microsoft Systems Engineer jobs with organizations seeking experienced professionals to design, implement, and support enterprise technology environments. These roles bring together expertise in Microsoft platforms, infrastructure, cloud services, security, and end-user computing. Ladders features vetted professional opportunities paying $100,000 or more, including positions for engineers who can keep complex systems reliable, secure, and ready to scale.

What Does a Microsoft Systems Engineer Do?

Microsoft Systems Engineers plan and maintain the systems that organizations rely on every day. Depending on the employer, responsibilities may include administering Windows Server environments, managing Microsoft 365 and Azure services, supporting identity and access management, automating deployments, and resolving infrastructure issues. Engineers may also contribute to architecture decisions, disaster recovery planning, endpoint management, and technical documentation.

Skills and Qualifications Employers Value

Employers commonly look for hands-on experience with Microsoft technologies such as Windows Server, Active Directory or Microsoft Entra ID, Microsoft 365, Azure, and PowerShell. Knowledge of networking, virtualization, cloud operations, cybersecurity, and systems monitoring can strengthen an application. Clear communication and the ability to collaborate across IT, security, and business teams are also important, especially in senior and enterprise roles. Relevant Microsoft certifications may help demonstrate specialized expertise.

Career Paths and Opportunities

Microsoft Systems Engineers work across industries, including technology, finance, healthcare, manufacturing, and government. Career paths can lead to senior systems engineering, cloud engineering, infrastructure architecture, technical leadership, or IT management. The right opportunity depends on your platform expertise, preferred work environment, and whether you want to focus on cloud migration, enterprise operations, security, or automation.

Find Microsoft Systems Engineer Jobs on Ladders

Use Ladders to explore vetted Microsoft Systems Engineer opportunities paying $100,000 or more. Review job requirements, compare roles, and identify positions that align with your experience in Microsoft infrastructure and enterprise systems. New listings may be added regularly, so check back to find opportunities suited to your next career move.

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$120K - $145K *

Lead the charge in shaping global healthcare packaging design. As a Principal Design Program Manager, you'll establish frameworks and standards, drive strategic decisions, and ensure seamless collabor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Empower your career by leading mechanical design for hyperscale data centers. Oversee HVAC, piping, and fire suppression systems while ensuring project success through collaboration and innovation. Jo...

Chicago, ILRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in designing and overseeing mechanical systems for hyperscale data centers, ensuring reliability and efficiency while managing client relationships and project teams across multiple di...

Los Angeles, CARemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Join a dynamic team as you lead the design and construction of mechanical systems for hyperscale data centers, ensuring reliability and efficiency while collaborating with global teams on high-profile...

Arlington, VARemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Innovate and drive AI agent development for clinical trial platforms, integrating LLMs through the .NET stack. Engage in hands-on engineering to deliver end-to-end AI features, enhancing patient-centr...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$134K - $223K *

Join a team that's dedicated to maximizing enterprise value through strategic consulting and technical expertise. Leverage your Sprinklr knowledge to drive customer success and innovation while foster...

Texas, USRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Join a team that's transforming healthcare by driving sales of innovative water purification systems. Leverage your expertise to build relationships and ensure compliance, enhancing patient safety acr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$100K - $140K *

Advance your career by driving growth in key industrial markets. Collaborate with engineers and stakeholders to build relationships, convert clients, and develop a robust sales pipeline while providin...

Colorado, USRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$75K - $95K *

Empower customer success through strategic account management and relationship building. Collaborate closely with clients to ensure satisfaction and retention, while driving revenue and addressing uni...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Unlock potential by leading comprehensive CFD studies for data centers, transforming complex simulations into actionable design insights. Collaborate globally on high-profile projects while ensuring h...

Arlington, VARemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$195K - $225K *

Innovate within a dynamic team to design, develop, and deploy advanced applications for a transformational initiative. Lead technical solutions and mentor engineers while ensuring optimal application...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Join a team that's shaping the future of utility-scale transmission projects. Oversee contractor activities, ensure quality installations, and foster strong relationships while managing project logist...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Aerospace & Defense

$140K - $155K *

Lead the strategic direction and operations for a collaborative utility forum, driving key initiatives in electric distribution while engaging with senior utility leaders to enhance industry practices...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $140K *

Champion talent acquisition by leading full-cycle recruitment and advising leaders on workforce strategies. Drive engagement and culture while building strong candidate pipelines and enhancing HR prac...

Vancouver, BCRemote

6 days ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $145K *

Join us to architect and automate cloud-native infrastructures while engaging directly with clients. Leverage your expertise in AI and DevOps to drive strategic solutions that align technology with bu...

Florida, USRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$84K - $87K *

Join us as a Data Operations Engineer, where you'll develop and manage data systems for healthcare claims processing. Collaborate with teams to ensure data accuracy and optimize ETL/ELT pipelines whil...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $180K *

Lead the charge in delivering enterprise-level growth programs by ensuring alignment across all functions, driving planning and execution adherence, and managing complex initiatives for timely product...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$157K - $238K *

Join a team that's redefining security by leveraging AI to enhance application safety. You'll assess vulnerabilities, develop innovative security solutions, and shape the AI security strategy across t...

Denver, CORemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$157K - $238K *

Lead the charge in enhancing application security by integrating AI-driven solutions, conducting assessments, and shaping the AI security strategy across the organization. Collaborate with cross-funct...

Seattle, WARemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Advance customer success by providing expert application support for separation technologies, driving product trials, and collaborating with sales teams to optimize solutions in the biotechnology sect...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead the charge in transforming legacy systems by leveraging your CA Gen expertise to modernize applications and drive technical innovation within a collaborative engineering team...

New York, NYRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Transform legacy technology by leading modernization efforts, utilizing your deep expertise in CA Gen and COBOL. Collaborate within a dynamic team to design specifications that support the successful...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead strategic initiatives by managing complex projects from inception to launch. Collaborate across teams to implement new markets and contracts, ensuring compliance and operational readiness in a dy...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$170K - $195K *

Lead the charge in global regulatory submissions, managing U.S. INDs and ex-U.S. CTAs. Collaborate cross-functionally to develop strategies, ensure compliance, and drive timely approvals in a fast-pac...

San Francisco, CARemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$186K - $232K *

Empower strategic partners by building deep technical relationships and driving preference for a modern data security platform. This role requires collaboration with various stakeholders to enhance pa...

Boston, MARemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What does a Microsoft Systems Engineer do?question toggle

    A Microsoft Systems Engineer designs, operates, and improves technology environments built on Microsoft platforms. Common work includes managing Windows Server, Microsoft 365, Azure, identity services, security controls, automation, and infrastructure support.

  • What skills are needed for Microsoft Systems Engineer jobs?question toggle

    Commonly requested skills include Windows Server administration, Microsoft 365, Azure, Active Directory or Microsoft Entra ID, PowerShell, networking, virtualization, troubleshooting, and security fundamentals. Requirements vary by role and employer.

  • Do Microsoft Systems Engineers need certifications?question toggle

    Certifications are not required for every position, but relevant Microsoft credentials can help demonstrate platform knowledge. Employers may value certifications related to Azure, Microsoft 365, identity, security, or administration, alongside practical experience.

  • How much do Microsoft Systems Engineer jobs pay?question toggle

    Compensation varies by experience, location, industry, and role scope. Ladders focuses on vetted professional jobs paying $100,000 or more, where available salary information and requirements are listed with each opportunity.

  • Where can I find Microsoft Systems Engineer jobs paying $100,000 or more?question toggle

    Explore Microsoft Systems Engineer listings on Ladders to find vetted professional opportunities with salaries of $100,000 or more. Compare job responsibilities and qualifications to identify roles that fit your background.