Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Senior Clinical Research Associate
$95K - $115K *
Transform clinical trial monitoring by ensuring adherence to protocols and regulatory standards. Collaborate with cross-functional teams to enhance data integrity and site performance while providing...
3 weeks ago
$125K - $138K *
Engineer operational excellence by leading the Problem Management team, driving post-incident processes, and fostering continuous improvement initiatives to enhance platform stability and customer exp...
1 week ago
Home Health Registered Nurse (7 On/7 Off)
$77K - $106K *
Join a team that's dedicated to providing personalized home health care, managing patient recovery plans, and collaborating with healthcare professionals to enhance patient independence and well-being...
2 weeks ago
$141K - $278K *
Drive innovative AI solutions by leading complex engagements, collaborating with clients, and delivering high-quality data science projects. Utilize your expertise in machine learning and data analyti...
5 days ago
NP or PA, MyCare 365 Primary Care & Urgent Care - Fayetteville Road
$95K - $115K *
Engage in delivering comprehensive medical care as a Physician Assistant or Nurse Practitioner, collaborating with a multidisciplinary team to enhance patient outcomes in both inpatient and outpatient...
1 week ago
Strategy and Operations - Revenue Integrity Lead
$125K - $235K *
Transform healthcare operations by partnering with client leaders to ensure effective Revenue Integrity during Epic implementations. Leverage your expertise to drive informed decisions and optimize re...
3 weeks ago
Associate Director, Methods and Data Standards
$125K - $145K *
Shape the future of data governance by leading methods and standards across enterprise systems. Collaborate with teams to define quality rules and documentation, ensuring consistency and excellence in...
3 days ago
Insurance - Industry & Function AI Decision Science Manager
$87K - $253K *
Empower organizations by leading innovative Data Science and AI initiatives. Manage cross-functional teams to deliver advanced analytics solutions, driving efficiency and growth while fostering strong...
5 days ago
Insurance - Industry & Function AI Decision Science Manager
$94K - $293K *
Lead the charge in managing end-to-end data science projects, leveraging AI and advanced analytics to drive efficiency and growth. Collaborate with teams and stakeholders to deliver innovative solutio...
5 days ago
$90K - $100K *
Empower our mission by ensuring cybersecurity compliance and risk management for the Veterans Health Administration's Enrollment System. Collaborate with stakeholders to maintain security documentatio...
5 days ago
CMMS (Computerized Maintenance Management System) Analyst
$59K - $104K *
Unlock potential by delivering strategic support in managing and optimizing the CMMS for Facilities Management. Collaborate with teams to enhance workflows, improve maintenance practices, and ensure e...
Reposted 3 weeks ago
$79K - $142K *
Elevate data-driven decision-making by transforming HR data into strategic insights. Leverage analytical skills and tools to enhance workforce performance and support HR initiatives, ensuring data acc...
Reposted 2 weeks ago
Registered Nurse (RN) - Home Health
$73K - $110K *
Optimize patient care through effective case management, coordinating multidisciplinary teams, and ensuring compliance with established care plans, targeting high-quality outcomes and patient satisfac...
Reposted 1 week ago
$88K - $105K *
Drive scientific excellence by leading assay execution, interpreting data, and collaborating across teams to ensure timely study progress and quality outcomes in a dynamic laboratory environment...
1 week ago
Software Engineer - ML Ops (R37)
$140K - $270K *
Unlock your potential by managing ML systems at scale, ensuring uptime and observability. Collaborate on deploying and scaling models, while enhancing platform reliability through advanced engineering...
2 weeks ago
Clinical Assessor - RN (Hybrid/Travel) - Vance County, NC
$67K - $93K *
Shape the future of healthcare by conducting vital assessments for eligibility in personal care services. This hybrid role combines home-based evaluations and community engagement, ensuring beneficiar...
3 weeks ago
Senior Product Manager, Epic Optimization
$101K - $152K *
Champion innovative solutions by leveraging Epic expertise to enhance operational efficiency and drive strategic initiatives across healthcare environments, ensuring high-performance standards and cli...
6 days ago
Senior Director, Data Architecture
$150K - $180K *
Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...
1 week ago
Director, Business Development - RCM Sales
$125K - $150K *
Unlock potential by leading sales strategies that drive revenue growth, collaborating with experts to execute impactful cycles, and consistently achieving quotas in a dynamic market focused on health...
3 weeks ago
$92K - $138K *
Lead client provisioning operations in Revenue Cycle Management, ensuring secure and efficient access throughout the user lifecycle. Collaborate with cross-functional teams to enhance service delivery...
1 week ago
Director of Clinical Quality and Outcomes (BCBA-D Preferred)
$110K - $130K *
Innovate clinical quality systems for scalable care delivery, ensuring standards meet payer expectations and driving measurable performance improvements across independent health providers...
Reposted 3 weeks ago
Infrastructure Engineering Senior Advisor- Hybrid
$110K - $130K *
Elevate your career by leading the design and implementation of complex infrastructure solutions. Collaborate across teams to troubleshoot and optimize technology systems, ensuring seamless operations...
3 weeks ago
$95K - $115K *
Shape the future of API management by designing and deploying robust solutions across diverse environments, ensuring seamless integration and operational excellence while mentoring clients to maximize...
6 days ago
$157K - $232K *
Lead the charge in building scalable data infrastructure for analytics. Collaborate with cross-functional teams to enhance data architecture, drive AI/ML initiatives, and establish governance across t...
3 weeks ago
$101K - $164K *
Join a dynamic research team as a Biostatistician III, where you'll lead statistical analysis and consultation for diverse nursing studies, enhancing healthcare outcomes and population health while co...
Reposted 3 weeks ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.