Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
AVP, Vendor Strategy & Cost Management
$163K - $220K *
Transform vendor strategies and cost management across the organization. Drive financial performance with analytics, lead sourcing events, and collaborate with cross-functional teams to optimize value...
Reposted 1 week ago
$90K - $110K *
Shape the future of consumer lending by analyzing credit risk and performance data to drive strategic insights for financial institutions, optimizing their underwriting processes and enhancing portfol...
Reposted 2 weeks ago
Associate — Client Intelligence & Analytics, Inventory Finance
$80K - $95K *
Unlock potential by building a comprehensive client intelligence capability, translating data into actionable insights that drive strategic decision-making and enhance business performance through eff...
Reposted today
$177K - $266K *
Strategize and lead regional sales initiatives, driving growth and profitability. Oversee a management team, develop business plans, and negotiate contracts while ensuring alignment with organizationa...
4 days ago
Associate Director, Clinical Data Integration & AI Programming
$158K - $197K *
Unlock potential by leading the automation of clinical data integration and dashboard development. Collaborate across teams to enhance data usability and implement AI solutions, ensuring compliance an...
3 weeks ago
Technical IBM Mainframe Applications/Systems Analyst
$75K - $105K *
Optimize mainframe systems as a key analyst, ensuring stability and performance of IBM z/OS environments. Collaborate with teams to troubleshoot issues and maintain critical applications, while enhanc...
4 days ago
Cybersecurity A&A Risk Analyst
$110K - $112K *
Elevate your career by providing advanced governance, risk, and compliance support for federal information systems, ensuring compliance with federal laws and regulations while engaging with key stakeh...
1 week ago
Registered Nurse PRN Home Health
$71K - $107K *
Champion patient care by assessing needs, coordinating services, and supporting transitions. Collaborate with healthcare teams to enhance patient independence and health outcomes while supervising sup...
3 days ago
Staff Software Engineer - Data Platform (HL7) (R37)
$212K - $409K *
Drive innovation as a key member of our engineering team, leveraging your expertise in software engineering and data platforms to shape solutions that enhance customer experiences and meet business go...
2 weeks ago
Manager of Statistical Programming
$132K - $165K *
Drive innovation in oncology diagnostics by leading statistical programming efforts, ensuring data integrity and compliance for clinical trials, while managing a team and collaborating cross-functiona...
1 week ago
Senior Project Manager - CNS (North America)
$128K - $254K *
Drive the successful delivery of Phase I-IV clinical trials by leading cross-functional teams, managing project timelines, budgets, and quality standards while fostering strong client relationships an...
Reposted 4 days ago
$100K - $120K *
Drive strategic oversight of enterprise-wide RAC audit activities, ensuring compliance and operational excellence. Collaborate with leadership to enhance audit processes, minimize financial risk, and...
6 days ago
Nurse Manager - Oncology Infusion Cary, NC
$85K - $100K *
Drive clinical excellence and operational leadership in ambulatory clinics, ensuring high standards of patient care, regulatory compliance, and effective resource management while fostering quality im...
1 week ago
Enterprise Service and Configuration Management Analyst
$66K - $106K *
Optimize IT service delivery by managing configuration items, analyzing operational data, and ensuring effective incident resolution. Collaborate with cross-functional teams to enhance service perform...
2 weeks ago
Associate - Financial Planning & Analysis (FP&A)
$80K - $95K *
Empower your career by driving financial insights and analytics. Collaborate across teams to transform data into strategic decisions, enhancing growth and efficiency in a dynamic environment. Join us...
Today
$129K - $177K *
Shape the future of developer tooling by leading strategy and governance for an enterprise ecosystem. Collaborate with cross-functional teams to enhance developer experience, drive automation, and ens...
3 days ago
$210K - $225K *
Pioneer innovative research strategies to enhance clinical outcomes and drive impactful insights through collaboration across teams, while establishing a robust research infrastructure and publication...
3 weeks ago
$103K - $128K *
Shape the future of healthcare by driving risk adjustment solutions that enhance interoperability, improve documentation accuracy, and ensure compliance across Medicare, Medicaid, and ACA programs thr...
Reposted 1 week ago
$103K - $128K *
Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...
3 weeks ago
$100K - $120K *
Join a team that's enhancing employee engagement and compliance through effective HR leadership. Oversee recruitment, onboarding, and support leadership in fostering a positive workplace culture acros...
3 weeks ago
Project Manager, FEHRM Healthcare Technology Management - Deployment
$95K - $125K *
Drive the deployment of healthcare technology across multiple VA facilities, coordinating projects and ensuring readiness. Collaborate with diverse teams to manage timelines, resolve issues, and deliv...
2 weeks ago
Sr. Manager, AI Performance & Operations
$110K - $173K *
Join a team that's redefining AI-driven quality and performance operations. You'll build systems that enhance frontline team effectiveness and AI agent performance, ensuring impactful coaching and fee...
3 weeks ago
Senior Epidemiological Programmer, Real World Evidence - FSP
$88K - $220K *
Lead the development of analytic datasets and conduct longitudinal analyses for observational studies in virology. Collaborate with epidemiologists and manage complex analyses while ensuring adherence...
1 week ago
Sr Analyst - Red Team Operator
$110K - $130K *
Lead and execute advanced red team operations, emulating real-world threats across diverse technology environments. Collaborate with security teams to enhance detection, response, and operational secu...
1 week ago
$105K - $129K *
Lead the charge in providing comprehensive care across independent, assisted, and skilled living environments. Manage outpatient practices, oversee clinical operations, and enhance resident well-being...
6 days ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.