Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Business Development Manager - Healthcare
$100K - $120K *
Join a team that's transforming healthcare by driving sales of innovative water purification systems. Leverage your expertise to build relationships and ensure compliance, enhancing patient safety acr...
3 weeks ago
AI & GenAI Data Scientist-Director
$155K - $410K *
Champion the design and implementation of AI solutions, enabling data-driven insights. Lead strategic initiatives, mentor teams, and drive business growth by fostering client relationships and deliver...
Reposted 2 weeks ago
Senior Analyst, ALM & Treasury
$88K - $141K *
Empower financial strategies by analyzing interest rate and liquidity risks. Collaborate with stakeholders to enhance capital planning and reporting processes while ensuring compliance with regulation...
3 days ago
Business Project Manager - Global Client Services
$105K - $150K *
Lead the charge in executive support and strategic sales initiatives, managing schedules, communications, and events for the EVP of Global Client Services. Drive efficiency and stakeholder engagement...
3 days ago
Applied Data Scientist – Performance Management & AI Solutions
$87K - $157K *
Innovate solutions by leveraging data, AI, and analytics to enhance operational performance. Collaborate with cross-functional teams to transform complex challenges into actionable insights, driving m...
1 week ago
Nurse Manager - Medical Cardiology Step Down
$80K - $95K *
Champion quality care as you oversee operations in our 40-bed clinical unit, driving efficiency, safety, and compassionate nursing practices while fostering staff development and adhering to regulator...
Reposted 1 week ago
$80K - $95K *
Elevate employee engagement by designing and managing benefits strategies that attract top talent, ensure compliance, and control costs, while collaborating closely with HR leadership for overall oper...
3 weeks ago
Technical Account Manager - Healthcare
$95K - $115K *
Drive the technical relationship with healthcare accounts, ensuring platform adoption, risk mitigation, and customer growth through proactive advisory and strategic planning. Collaborate with IT teams...
6 days ago
Associate Director, Talent Analytics & Assessment Science
$132K - $193K *
Unlock potential by leading the enterprise employee listening strategy, enhancing assessment science, and applying analytics to drive data-informed talent decisions. Collaborate with cross-functional...
2 weeks ago
IT Infrastructure Design Engineer
$100K - $120K *
Join a team that's dedicated to innovation and excellence, driving projects from concept to completion. Collaborate with cross-functional teams to enhance product development and ensure quality standa...
2 weeks ago
Nurse Manager, Operations - Emergency Department - Duke Health Cary
$88K - $105K *
Champion high-quality patient care by leading operations in a dynamic Emergency Department. Provide 24/7 oversight, support staff development, and ensure compliance with standards while fostering a co...
Reposted today
SDC Senior Business Systems Analyst---Raleigh, NC, or Dallas, TX
$67K - $136K *
Contribute to transformative technology solutions by leveraging business insights and collaborative analysis to enhance clients' systems and processes while adapting to an ever-changing environment. J...
Reposted 6 days ago
Senior Financial Analyst, FP&A (R&D)
$111K - $167K *
Transform financial operations by driving monthly close processes, managing forecasts, and leveraging AI for process improvements while serving as a key business partner to leadership to enhance strat...
Reposted today
$133K - $180K *
Join a team that's redefining member experiences by architecting optimal journeys, bridging operational execution with strategic vision to enhance engagement and satisfaction across all touchpoints...
Reposted yesterday
Director of Insurance Plan Management
$120K - $150K *
Transform the landscape of dental negotiations by leading strategic partnerships with payers, optimizing contracts, and driving revenue growth through data-driven insights and collaborative execution...
1 week ago
Director, Enterprise Oncology & Dx Strategy
$150K - $180K *
Develop strategic initiatives across Oncology and Diagnostics, driving alignment and execution. Collaborate with senior leaders to enhance organizational performance and support decision-making throug...
6 days ago
Field Reimbursement Manager, Oncology
$110K - $130K *
Shape the future of patient access by educating healthcare providers on reimbursement and support programs. Collaborate with oncology stakeholders to enhance patient care and navigate complex payer la...
5 days ago
Senior Actuary, US Reporting & Analysis
$139K - $170K *
Empower the actuarial reporting process by ensuring accurate US Statutory, GAAP, and Tax reporting. Collaborate with finance teams to analyze financial results, support audits, and drive process impro...
1 week ago
Wealth Institutional Administration and Operations Senior Analyst
$80K - $95K *
Transform client experiences by managing complex accounts, ensuring efficient operations, and enhancing service delivery. Collaborate with teams to streamline processes and maintain high standards of...
5 days ago
Nurse Practitioner OR Physician Assistant
$90K - $110K *
Manage primary medical care within an occupational health program, ensuring quality patient management, diagnostic testing, and therapeutic procedures while collaborating with healthcare professionals...
3 weeks ago
Life Sciences Data Management, Lead (MDM/DGov)
$134K - $265K *
Shape innovative data management solutions for Life Sciences, focusing on Customer MDM and data governance. Lead client engagements, drive commercial transformation, and foster high-performing teams t...
3 days ago
$168K - $231K *
Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...
3 days ago
Hospice & Palliative - NP - Full-Time
$99K - $148K *
Help us deliver quality palliative care through comprehensive patient assessments, treatment planning, and collaborative support. Engage with patients and teams to ensure excellent health outcomes and...
Reposted 3 weeks ago
Project Manager, FEHRM Healthcare Technology Management - Interoperability
$95K - $125K *
Advance your career by coordinating healthcare technology integration across multiple VA sites. Leverage your project management skills to support the Federal Electronic Health Record Modernization pr...
3 weeks ago
Senior Information Governance Advisor
$114K - $218K *
Lead the charge in establishing and enforcing data governance policies, ensuring data quality and compliance. Collaborate across teams to drive initiatives that enhance operational data integrity and...
1 week ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.