Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Applications Analyst- Epic Professional Billing
$67K - $111K *
Elevate your career by providing critical analysis and programming support for application software, ensuring a comprehensive and integrated information network that meets diverse customer needs and e...
1 week ago
Senior AI Software Engineer (Healthcare)
$120K - $145K *
Engage in cutting-edge AI development by designing and scaling intelligent applications. Leverage Generative AI and modern tools to enhance productivity and integrate workflows within healthcare platf...
Reposted 1 week ago
Configuration Analyst -Oncology (Hybrid Kansas City, MO office)
$53K - $132K *
Deliver exceptional configuration solutions while fostering collaboration among teams. Leverage your Oracle Health Oncology expertise to drive improvements and ensure high-quality outcomes in diverse...
Reposted 3 weeks ago
$175K - $210K *
Lead the charge in driving enterprise growth within healthcare by building relationships with national and regional health plans. Own new logo acquisition and expansion, leveraging a robust support sy...
2 weeks ago
$72K - $94K *
Contribute to program success by planning, coordinating, and executing activities. Collaborate with teams and stakeholders to monitor progress, manage risks, and analyze data, ensuring objectives are...
5 days ago
$79K - $127K *
Drive your career forward by overseeing tax compliance and accounting functions. You'll conduct research, manage filings, and identify opportunities while ensuring adherence to evolving tax laws. Join...
4 weeks ago
Senior Manager - APR DRG Concept Development Analyst
$100K - $125K *
Transform healthcare analytics by leading the development of APR-DRG audit criteria. Collaborate with cross-functional teams to enhance payment integrity through data-driven insights and innovative so...
2 weeks ago
Business Analytics Advisor - Remote
$98K - $163K *
Transform data insights into actionable strategies by leading advanced analytics initiatives. Collaborate with cross-functional teams to enhance provider relations through innovative dashboards and re...
Today
Business Analytics Advisor - Remote
$98K - $163K *
Transform data insights into actionable strategies by leading analytics initiatives, developing dashboards, and collaborating with cross-functional teams to enhance provider operations and decision-ma...
Today
Senior Revenue Integrity Analyst
$80K - $95K *
Explore advanced revenue analysis and month-end controls to ensure accurate invoicing and financial reporting. Collaborate across functions to resolve discrepancies, mentor junior analysts, and drive...
3 weeks ago
$92K - $115K *
Unlock potential by leading requirements documentation for software projects. Collaborate with stakeholders and technical teams to ensure successful delivery throughout the project lifecycle, while su...
2 weeks ago
Senior Analyst, Project Management
$46K - $122K *
Optimize customer benefit plan implementations by collaborating with stakeholders to ensure satisfaction, executing strategic plans, and resolving issues efficiently while driving continuous improveme...
Reposted yesterday
$95K - $115K *
Empower your career by providing analytic support for performance improvement and labor productivity initiatives. Collaborate with leaders to develop standards, enhance data integrity, and optimize be...
2 weeks ago
$110K - $130K *
Join a team that's dedicated to driving growth in healthcare accounts. Leverage your strategic sales expertise to build relationships, identify opportunities, and deliver value in a fast-paced environ...
6 days ago
$80K - $95K *
Empower healthcare delivery by integrating clinical science with technology. Collaborate with teams to enhance workflows, resolve issues, and support the adoption of electronic health records for impr...
3 days ago
$95K - $115K *
Champion client success by managing complex engagements in healthcare solutions. Leverage your expertise to enhance Quality/HEDIS, CMS Stars, and Risk Adjustment outcomes, ensuring effective adoption...
Today
$70K - $118K *
Join a dynamic team to deliver impactful data analysis and reporting solutions, enhancing operational efficiency and decision-making through the Microsoft Power Platform and hands-on analytical suppor...
6 days ago
Lead IT Systems Apps Analyst-Epic
$100K *
Grow your career with a pivotal role in designing and optimizing enterprise applications. Collaborate with cross-functional teams to enhance clinical operations, ensuring alignment with best practices...
3 weeks ago
Director, AI Vendor Integrations & Standards
$146K - $269K *
Empower innovation by leading vendor AI integration standards, ensuring compliance and interoperability across the enterprise. Drive assessments, manage relationships, and oversee ongoing adherence to...
3 days ago
$120K - $147K *
Shape your career by leading data integration initiatives that drive enterprise-wide consistency and governance. Collaborate with stakeholders to deliver trusted, scalable data products while ensuring...
1 week ago
Senior Analyst, Private Debt & Equity Operations
$89K - $134K *
Grow your career with a dynamic role focused on private debt and equity operations. Leverage your expertise in asset lifecycle servicing while guiding junior team members and driving process improveme...
3 weeks ago
Senior Compliance Analyst-Advisory Services
$95K - $115K *
Lead the charge in enhancing compliance processes within advisory services, utilizing your expertise to develop efficient oversight procedures, conduct data quality control, and ensure adherence to re...
1 week ago
Senior Revenue Integrity Analyst
$80K - $95K *
Elevate healthcare revenue integrity by leading charge capture audits, optimizing compliance, and driving financial performance through detailed analyses and collaboration across clinical departments...
Reposted 4 days ago
Product Analyst / Senior Product Analyst
$80K - $130K *
Join a team that's driving product strategy through data analysis and insights. Collaborate with cross-functional teams to enhance product performance, uncover growth opportunities, and influence stra...
2 weeks ago
Healthcare Provider Back Office Consulting - Senior Associate
$77K - $202K *
Transform healthcare provider operations by analyzing processes, implementing software solutions, and guiding teams. Leverage critical thinking to enhance efficiency and build strong client relationsh...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.