Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$67K - $111K *

Elevate your career by providing critical analysis and programming support for application software, ensuring a comprehensive and integrated information network that meets diverse customer needs and e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Engage in cutting-edge AI development by designing and scaling intelligent applications. Leverage Generative AI and modern tools to enhance productivity and integrate workflows within healthcare platf...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$53K - $132K *

Deliver exceptional configuration solutions while fostering collaboration among teams. Leverage your Oracle Health Oncology expertise to drive improvements and ensure high-quality outcomes in diverse...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$175K - $210K *

Lead the charge in driving enterprise growth within healthcare by building relationships with national and regional health plans. Own new logo acquisition and expansion, leveraging a robust support sy...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$72K - $94K *

Contribute to program success by planning, coordinating, and executing activities. Collaborate with teams and stakeholders to monitor progress, manage risks, and analyze data, ensuring objectives are...

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$79K - $127K *

Drive your career forward by overseeing tax compliance and accounting functions. You'll conduct research, manage filings, and identify opportunities while ensuring adherence to evolving tax laws. Join...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Transform healthcare analytics by leading the development of APR-DRG audit criteria. Collaborate with cross-functional teams to enhance payment integrity through data-driven insights and innovative so...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$98K - $163K *

Transform data insights into actionable strategies by leading advanced analytics initiatives. Collaborate with cross-functional teams to enhance provider relations through innovative dashboards and re...

Today

  •   5 - 7 years exp.  •   Healthcare

$98K - $163K *

Transform data insights into actionable strategies by leading analytics initiatives, developing dashboards, and collaborating with cross-functional teams to enhance provider operations and decision-ma...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Explore advanced revenue analysis and month-end controls to ensure accurate invoicing and financial reporting. Collaborate across functions to resolve discrepancies, mentor junior analysts, and drive...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $115K *

Unlock potential by leading requirements documentation for software projects. Collaborate with stakeholders and technical teams to ensure successful delivery throughout the project lifecycle, while su...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$46K - $122K *

Optimize customer benefit plan implementations by collaborating with stakeholders to ensure satisfaction, executing strategic plans, and resolving issues efficiently while driving continuous improveme...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Empower your career by providing analytic support for performance improvement and labor productivity initiatives. Collaborate with leaders to develop standards, enhance data integrity, and optimize be...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Join a team that's dedicated to driving growth in healthcare accounts. Leverage your strategic sales expertise to build relationships, identify opportunities, and deliver value in a fast-paced environ...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Empower healthcare delivery by integrating clinical science with technology. Collaborate with teams to enhance workflows, resolve issues, and support the adoption of electronic health records for impr...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Champion client success by managing complex engagements in healthcare solutions. Leverage your expertise to enhance Quality/HEDIS, CMS Stars, and Risk Adjustment outcomes, ensuring effective adoption...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$70K - $118K *

Join a dynamic team to deliver impactful data analysis and reporting solutions, enhancing operational efficiency and decision-making through the Microsoft Power Platform and hands-on analytical suppor...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$100K *

Grow your career with a pivotal role in designing and optimizing enterprise applications. Collaborate with cross-functional teams to enhance clinical operations, ensuring alignment with best practices...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$146K - $269K *

Empower innovation by leading vendor AI integration standards, ensuring compliance and interoperability across the enterprise. Drive assessments, manage relationships, and oversee ongoing adherence to...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $147K *

Shape your career by leading data integration initiatives that drive enterprise-wide consistency and governance. Collaborate with stakeholders to deliver trusted, scalable data products while ensuring...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$89K - $134K *

Grow your career with a dynamic role focused on private debt and equity operations. Leverage your expertise in asset lifecycle servicing while guiding junior team members and driving process improveme...

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Lead the charge in enhancing compliance processes within advisory services, utilizing your expertise to develop efficient oversight procedures, conduct data quality control, and ensure adherence to re...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Elevate healthcare revenue integrity by leading charge capture audits, optimizing compliance, and driving financial performance through detailed analyses and collaboration across clinical departments...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $130K *

Join a team that's driving product strategy through data analysis and insights. Collaborate with cross-functional teams to enhance product performance, uncover growth opportunities, and influence stra...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$77K - $202K *

Transform healthcare provider operations by analyzing processes, implementing software solutions, and guiding teams. Leverage critical thinking to enhance efficiency and build strong client relationsh...

Today

  •   Less than 5 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.