Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$88K - $128K *

Drive impactful actuarial analyses and modeling to enhance healthcare services, collaborating with teams to ensure accurate financial forecasting and decision support that shapes health program strate...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$124K - $140K *

Lead data analytics initiatives by defining priorities and timelines to deliver actionable insights and research projects. Collaborate with cross-functional teams to enhance data-driven decision-makin...

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$74K - $91K *

Join our team to investigate healthcare fraud, waste, and abuse through data analysis. Utilize your expertise in Excel and communication skills to analyze cases, conduct interviews, and support legal...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Support public health initiatives by managing community grant portfolios, providing technical assistance, and enhancing local coalitions' capacity to prevent youth substance use. Collaborate with stak...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$138K - $172K *

Empower revenue teams as a Senior Business Systems Analyst, driving efficiency through Salesforce architecture, process design, and actionable data across GTM, Marketing, Sales, and Customer Success o...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$96K - $116K *

Champion innovative medical policy solutions by analyzing data, ensuring quality, and collaborating across clinical operations. Drive enhancements in payment policy management while supporting diverse...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Shape the future of healthcare revenue management by leading IDR processes, ensuring compliance, and driving data-informed improvements while mentoring a team of analysts to optimize workflows and enh...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Elevate healthcare interoperability by designing and supporting MEDITECH interfaces. Collaborate with teams to enhance data exchange, improve patient care, and ensure seamless integration across syste...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $125K *

Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$108K - $149K *

Advance the organization by establishing robust data and AI governance practices. Collaborate across teams to ensure compliance, integrity, and responsible usage of data and AI assets, supporting both...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Unlock potential by leveraging your expertise in data analysis and psychometrics to drive innovative assessment solutions. Collaborate with a dynamic team to enhance educational outcomes through advan...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$140K - $270K *

Unlock your potential as a Research Scientist, driving AI innovations in healthcare. Collaborate with cross-functional teams to develop and implement cutting-edge machine learning models that enhance...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $113K *

Transform proposal management by leading cross-functional teams to deliver high-quality, compliant responses. Drive efficiency through strategic planning, risk management, and collaboration, ensuring...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$72K - $116K *

Engage in financial analysis and reporting, developing forecasts and insights. Collaborate across departments to enhance business outcomes and present findings to management, driving strategic decisio...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$89K - $148K *

Drive data quality assurance and validation across enterprise platforms, ensuring compliance and accuracy. Collaborate with stakeholders to enhance data workflows and implement testing strategies for...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $100K *

Optimize data-driven strategies to enhance customer engagement and retention. Collaborate with operations to implement scalable solutions in a dynamic startup environment, making a significant impact...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Transportation

$150K - $200K *

Unlock potential by defining and guiding enterprise architecture, integrating cloud, infrastructure, and security to support business priorities. Lead modernization efforts and influence cross-functio...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$95K - $105K *

Unlock potential by providing financial analysis and operational support for a complex government contract. Collaborate with leadership and teams to ensure effective budgeting, reporting, and subcontr...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$113K - $188K *

Shape the future of healthcare reimbursement by developing and implementing payment policies that enhance accuracy, compliance, and provider experience in a dynamic payer environment. Collaborate with...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Analyze financial performance and operational metrics to support strategic growth initiatives. Collaborate with cross-functional teams to enhance reporting accuracy and drive insights for decision-mak...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$119K - $179K *

Lead the charge in architecting FHIR-compliant data models to enhance clinical data integration and usability, supporting patient care and research initiatives across the organization...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Unlock your potential by driving business application solutions and leading requirements elicitation. Collaborate across teams to enhance processes and systems, ensuring alignment with business object...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by designing and building robust data pipelines for healthcare transactions. Collaborate with partners to ensure seamless integration and reliability of data systems, enhancing operat...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Drive innovation by enhancing Finance systems through design, implementation, and analytics. Collaborate with cross-functional teams to ensure data integrity and optimize processes, while mentoring an...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.