Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$70K - $137K *
Elevate agricultural finance research by leading the Early Warning System, engaging stakeholders, and developing analytical tools to assess farm financial conditions and risks, driving informed decisi...
3 weeks ago
Strategic Account Executive, Healthcare - TOLA
$125K - $150K *
Join a team that's driving enterprise growth in healthcare across the TOLA region. Leverage your strategic selling skills to open new accounts and build executive relationships, transforming patient e...
Today
Manager, Business Product Owner - Risk Stratification & Assessment
$107K - $199K *
Shape the future of Care Management solutions by leading strategic planning, defining product strategies, and collaborating with stakeholders to enhance healthcare delivery and profitability...
Today
Deal Advisory Director (Healthcare)
$192K - $334K *
Tackle complex healthcare M&A engagements, leading due diligence efforts, and collaborating with clients and teams to drive value. Manage multiple projects while utilizing your expertise to influence...
Reposted 3 weeks ago
$119K - $179K *
Support the integration and harmonization of clinical data by designing FHIR-compliant models and pipelines, ensuring data accuracy and usability for patient care and research initiatives across the o...
3 weeks ago
$93K - $140K *
Accelerate progress at defining technical requirements and solutions, collaborating with business experts to enhance operational processes. Lead projects, mentor analysts, and ensure alignment of tech...
3 weeks ago
Director, Quality Intelligence & Causal Analysis
$200K - $240K *
Optimize quality intelligence and root cause analysis initiatives to enhance audit quality. Lead data-driven insights and predictive risk assessments, collaborating with stakeholders to identify trend...
1 week ago
Account Executive, Small Group
$75K - $90K *
Lead the charge in driving sales growth by engaging independent physician practices. Utilize your expertise in full-cycle sales to build relationships, conduct virtual demos, and collaborate with team...
3 weeks ago
Marketing Data Analytics Engineer (US)
$87K - $97K *
Shape the future of marketing analytics by building robust data pipelines and automating reporting workflows. Collaborate with cross-functional teams to enhance data quality and leverage AI tools for...
3 weeks ago
Head of National Strategic Accounts
$250K - $300K *
Champion strategic growth by leading the charge to secure complex health system accounts. Drive transformative deals with hands-on coaching, leveraging deep relationships and expertise to elevate team...
Reposted 2 weeks ago
eDiscovery Analyst, Enterprise Accounts
$100K - $120K *
Champion the management and execution of complex e-discovery projects, collaborating with legal teams to ensure successful outcomes. Oversee multiple projects while mentoring a team, maintaining quali...
2 weeks ago
Director - Population Health & Well Being
$150K - $160K *
Lead the charge in executing population health strategies, ensuring high-quality consulting delivery and team performance across regions. Collaborate with leadership to drive impactful solutions and f...
6 days ago
Senior Analyst, Professional Medicaid Reimbursement - SQL/QNXT/NetworX - Remote
$80K - $95K *
Unlock potential by providing senior-level analyst support for complex provider reimbursement activities. Collaborate with stakeholders to implement and maintain reimbursement methodologies across var...
Reposted yesterday
$80K - $95K *
Empower your career as a Data Advisor, driving data integrity and operational excellence in security reference data and pricing. Collaborate across teams to enhance processes and support strategic ini...
5 days ago
$150K - $180K *
Shape and execute a comprehensive partnership strategy to drive growth, enhance market presence, and foster high-value alliances across the healthcare ecosystem, collaborating with executive leadershi...
5 days ago
Clinical Research Associate II
$80K - $95K *
Lead the execution of clinical trials by monitoring site activities, ensuring compliance with regulations, and collaborating with teams to achieve study objectives. Play a key role in training site st...
1 week ago
$80K - $95K *
Unlock potential by leading compliance audits, ensuring accurate coding and documentation in anesthesia. Collaborate with teams to mitigate risks, deliver training, and maintain regulatory standards w...
6 days ago
Director of Health Plan Business Development
$180K - $210K *
Lead the charge in advancing strategic partnerships with health plans. Shape and optimize BetterHelp’s payer strategy, enhance agreements, and identify growth opportunities while collaborating across...
Reposted yesterday
$107K - $172K *
Shape the future of cash management by enhancing forecasting capabilities and providing critical insights for strategic decision-making, operational planning, and capital allocation in a dynamic envir...
Reposted 4 weeks ago
$124K - $155K *
Champion data-driven insights as you lead a multidisciplinary analytics team, driving client performance and strategic recommendations to enhance business growth and market competitiveness...
1 week ago
$105K - $202K *
Create innovative AI-powered healthcare products by transforming complex workflows into intuitive applications. Collaborate with cross-functional teams to deliver impactful user experiences and own fe...
3 weeks ago
$102K - $190K *
Innovate data management processes by leading the development of robust data pipelines, ensuring high-quality data for analytics and reporting. Collaborate with cross-functional teams to enhance data...
Reposted 4 days ago
$125K *
Engage with clients by leveraging data analysis and technical expertise to drive revenue growth. Collaborate with sales teams to ensure data accuracy and create tailored solutions, enhancing customer...
1 month ago
Principal IT Analyst - Veeva RIM
$121K - $161K *
Transform your career by leading the design and implementation of Veeva Vault RIM, ensuring optimal performance and compliance while collaborating with cross-functional teams to enhance user experienc...
4 weeks ago
$58K - $105K *
Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.