Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$90K - $115K *

Lead the charge in transforming complex business needs into impactful analytic products. Collaborate with stakeholders to design, develop, and maintain reusable semantic models that enhance decision-m...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Drive healthcare innovation by leading interoperability initiatives for Medicaid, ensuring compliance and collaboration across departments to enhance services for Missouri's vulnerable populations...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$59K - $132K *

Execute comprehensive testing strategies to ensure quality and compliance across various solutions. Manage testing queues, document results, and collaborate with teams to enhance processes while adher...

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Inspire data-driven decision-making as you lead analytics and predictive modeling efforts. Collaborate across teams to enhance patient engagement, forecast demand, and measure impact, driving strategi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $239K *

Elevate client relationships in the Healthcare sector by driving new business development and managing diverse portfolios. Collaborate with teams to ensure compliance and deliver tailored solutions th...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$113K - $188K *

Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$73K - $110K *

Shape the future of coding quality by overseeing audits, developing guidance, and collaborating with teams to enhance accuracy and compliance in healthcare coding practices...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$46K - $122K *

Lead the charge in developing pricing strategies and financial models for PBM client contracts. Collaborate with sales and account teams to optimize revenue and profitability while presenting analyses...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$79K - $127K *

Innovate with us to enhance data protection strategies, ensuring robust security and compliance across diverse platforms. Collaborate on complex projects, troubleshoot incidents, and drive improvement...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $140K *

Shape the future of public service by leading technology consulting projects that enhance operational efficiency and strategic goals for state and local agencies, ensuring compliance and delivering im...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$82K - $182K *

Analyze healthcare costs and quality outcomes to drive value-based care strategies, collaborating with clinical and financial teams. Lead data-driven insights and financial modeling to enhance operati...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$198K - $297K *

Engage in a dynamic role that empowers team collaboration and drives results in a leading organization recognized for innovation and excellence in performance, fostering an environment of growth and p...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $120K *

Join a team that's dedicated to enhancing data-driven decision-making for VA modernization initiatives. Leverage your analytical skills to assess workflows, document processes, and deliver actionable...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$140K - $270K *

Unlock potential by designing and deploying scalable AI systems that transform healthcare workflows. Collaborate with cross-functional teams to solve complex business challenges and drive measurable o...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$122K - $183K *

Transform how we operate by leading technology-driven initiatives that enhance business capabilities. Collaborate with cross-functional teams to define product strategies and drive measurable outcomes...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $129K *

Drive impactful market analysis and reporting as a Senior Analyst, leveraging data to guide strategic investments and growth opportunities. Collaborate with teams to enhance decision-making and optimi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$109K - $182K *

Shape the future of rebate modeling by collaborating with cross-functional teams to optimize strategies and processes, driving value for clients and enhancing overall supply chain efficiency...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $162K *

Develop and lead actuarial processes for Medicare Value-Based Care, managing monthly results, payer settlements, and special projects. Collaborate with cross-functional teams to enhance analytics and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$176K - $230K *

Drive impactful healthcare innovations by leveraging data science to enhance patient outcomes. Lead projects from concept to business impact, collaborating with stakeholders and mentoring peers to del...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Empower cross-functional teams to innovate and enhance platform capabilities, ensuring alignment with client needs and regulatory standards. Drive product vision from inception to adoption, leveraging...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $172K *

Elevate your career by driving growth in national health plan accounts. Leverage your expertise to build relationships, negotiate complex deals, and exceed revenue targets while collaborating with cro...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $190K *

Manage strategic sales relationships with national accounts to drive growth in value-based care. Collaborate with leadership teams, execute contract strategies, and support implementations to enhance...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$72K - $100K *

Join our dynamic team as a Sr. Credit Analyst, owning the underwriting cycle from application review to decision-making. Leverage your analytical skills to enhance credit processes and contribute to a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$98K - $156K *

Drive impactful pharmacy strategies by leveraging actuarial expertise and data analytics. Collaborate across teams to transform insights into actionable strategies, enhancing profitability and perform...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$142K - $168K *

Transform client experiences by leveraging deep expertise in healthcare solutions. Lead strategic initiatives, enhance client relationships, and drive impactful outcomes for high-value accounts throug...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.