Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$100K - $120K *

Advance global service delivery by managing offshore partnerships, ensuring performance excellence, and driving operational improvements across teams to enhance productivity and quality outcomes...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$124K - $280K *

Transform healthcare operations by leading finance, supply chain, and HCM consulting projects. Drive efficiency and technology integration while advising clients and coaching teams through complex tra...

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$124K - $280K *

Lead the charge in transforming healthcare finance, supply chain, and HCM operations. Drive strategic initiatives, enhance efficiency, and guide teams through complex projects while advising clients o...

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$124K - $280K *

Lead transformative consulting initiatives in healthcare finance, supply chain, and HCM. Drive operational efficiency and technology integration while guiding teams through complex projects and foster...

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$124K - $280K *

Drive transformative change in healthcare by leading finance, supply chain, and HCM projects. Collaborate with clients to enhance operational efficiency and guide technology adoption, ensuring alignme...

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$85K *

Innovate with us by partnering with business leaders to streamline operations. As a Technical Business Analyst, you'll oversee the entire process from request intake to solution delivery, ensuring sca...

Reposted today

  •   Less than 5 years exp.  •   Business Services

$136K - $239K *

Unlock your potential by leading statistical programming efforts in clinical trials. Collaborate with cross-functional teams to analyze and report clinical data, ensuring compliance with industry stan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to managing risk adjustment programs, ensuring compliance, and delivering insightful analytics to enhance revenue alignment with health status. Collaborate with leaders to...

4 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$113K - $164K *

Lead the charge in enhancing client success by strategically advising high-impact clients, fostering executive relationships, and driving solution adoption while mitigating risks and ensuring measurab...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Legal & Accounting

$90K - $119K *

Optimize compliance and risk management by conducting thorough audits, collaborating cross-functionally, and driving continuous improvement in adherence to regulatory standards and operational practic...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Lead the charge in enhancing nursing education through innovative simulation experiences, ensuring quality outcomes and faculty support while fostering a collaborative learning environment for student...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$272K - $374K *

Develop strategic relationships with key healthcare accounts, driving innovation and sales growth. Leverage your expertise in big data and cloud technologies to exceed targets and deliver exceptional...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Advance healthcare solutions by developing scalable ML systems, collaborating with cross-functional teams, and driving innovative AI methodologies to enhance patient outcomes and optimize operational...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive customer success by fostering executive relationships and ensuring retention and growth across a defined portfolio. Leverage strategic insights to translate customer outcomes into measurable bus...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$76K - $131K *

Join a team that's redefining healthcare compliance by leading detailed coding audits, mentoring auditors, and driving innovative solutions to enhance compliance and operational excellence in a dynami...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$69K - $103K *

Join a team that's dedicated to ensuring seamless member scheduling and access. As a Production Support Analyst, you'll monitor platform health, resolve data issues, and collaborate with cross-functio...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$93K - $97K *

Contribute to program success by supporting planning, execution, and management of projects. Analyze data, prepare reports, and optimize resources to ensure objectives are met within scope, time, and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $220K *

Lead the sales strategy for a healthcare Payer business unit, driving market penetration, revenue growth, and client satisfaction. Collaborate with leadership to shape go-to-market strategies and buil...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to transforming healthcare data solutions. As a Senior Data Engineer, you'll enhance complex systems, collaborate across departments, and drive analytics to optimize finan...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Elevate healthcare through strategic AI product management, driving innovation and lifecycle management of AI solutions. Collaborate cross-functionally to align business objectives with customer needs...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$94K - $107K *

Transform data governance operations by driving process adoption, supporting data stewards, and enhancing governance tools. Collaborate with teams to ensure compliance, improve workflows, and leverage...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$85K - $110K *

Empower quality assurance by overseeing clinical audits, ensuring accuracy and consistency. Collaborate with auditors to enhance performance, mentor teams, and drive process improvements in a remote e...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$90K - $115K *

Lead the charge in transforming complex business needs into impactful analytic products. Collaborate with stakeholders to design, develop, and maintain reusable semantic models that enhance decision-m...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Drive healthcare innovation by leading interoperability initiatives for Medicaid, ensuring compliance and collaboration across departments to enhance services for Missouri's vulnerable populations...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$59K - $132K *

Execute comprehensive testing strategies to ensure quality and compliance across various solutions. Manage testing queues, document results, and collaborate with teams to enhance processes while adher...

Today

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.